Search Results - "Carroll, Richard G."

Bcl-2 Family Proteins Participate in Mitochondrial Quality Control by Regulating Parkin/PINK1-Dependent Mitophagy by Hollville, Emilie, Carroll, Richard G., Cullen, Sean P., Martin, Seamus J.

“…Mitophagy facilitates the selective elimination of impaired or depolarized mitochondria through targeting the latter to autophagosomes. Parkin becomes…”
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Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1 by Carroll, Richard G., Hollville, Emilie, Martin, Seamus J.

“…Mitochondrial depolarization promotes Parkin- and PTEN-induced kinase 1 (PINK1)-dependent polyubiquitination of multiple proteins on mitochondrial outer…”
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An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation by Carroll, Richard G., Zasłona, Zbigniew, Galván-Peña, Silvia, Koppe, Emma L., Sévin, Daniel C., Angiari, Stefano, Triantafilou, Martha, Triantafilou, Kathy, Modis, Louise K., O’Neill, Luke A.

“…Different immune activation states require distinct metabolic features and activities in immune cells. For instance, inhibition of fatty acid synthase (FASN),…”
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Malonylation of GAPDH is an inflammatory signal in macrophages by Galván-Peña, Silvia, Carroll, Richard G., Newman, Carla, Hinchy, Elizabeth C., Palsson-McDermott, Eva, Robinson, Elektra K., Covarrubias, Sergio, Nadin, Alan, James, Andrew M., Haneklaus, Moritz, Carpenter, Susan, Kelly, Vincent P., Murphy, Michael P., Modis, Louise K., O’Neill, Luke A.

“…Macrophages undergo metabolic changes during activation that are coupled to functional responses. The gram negative bacterial product lipopolysaccharide (LPS)…”
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The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing by Cervantes-Silva, Mariana P., Carroll, Richard G., Wilk, Mieszko M., Moreira, Diana, Payet, Cloe A., O’Siorain, James R., Cox, Shannon L., Fagan, Lauren E., Klavina, Paula A., He, Yan, Drewinski, Tabea, McGinley, Alan, Buel, Sharleen M., Timmons, George A., Early, James O., Preston, Roger J. S., Hurley, Jennifer M., Finlay, David K., Schoen, Ingmar, Javier Sánchez-García, F., Mills, Kingston H. G., Curtis, Annie M.

“…Dendritic cells play a key role in processing and presenting antigens to naïve T cells to prime adaptive immunity. Circadian rhythms are known to regulate many…”
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Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains by Carpenito, Carmine, Milone, Michael C, Hassan, Raffit, Simonet, Jacqueline C, Lakhal, Mehdi, Suhoski, Megan M, Varela-Rohena, Angel, Haines, Kathleen M, Heitjan, Daniel F, Albelda, Steven M, Carroll, Richard G, Riley, James L, Pastan, Ira, June, Carl H

“…Mesothelin is a cell-surface molecule over-expressed on a large fraction of carcinomas, and thus is an attractive target of immunotherapy. A molecularly…”
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Caspase-11 promotes allergic airway inflammation by Zasłona, Zbigniew, Flis, Ewelina, Wilk, Mieszko M., Carroll, Richard G., Palsson-McDermott, Eva M., Hughes, Mark M., Diskin, Ciana, Banahan, Kathy, Ryan, Dylan G., Hooftman, Alexander, Misiak, Alicja, Kearney, Jay, Lochnit, Gunter, Bertrams, Wilhelm, Greulich, Timm, Schmeck, Bernd, McElvaney, Oliver J., Mills, Kingston H. G., Lavelle, Ed C., Wygrecka, Małgorzata, Creagh, Emma M., O’Neill, Luke A. J.

“…Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E 2 (PGE 2 ) inhibits…”
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The Circadian Clock Protein BMAL1 Acts as a Metabolic Sensor In Macrophages to Control the Production of Pro IL-1β by Timmons, George A, Carroll, Richard G, O'Siorain, James R, Cervantes-Silva, Mariana P, Fagan, Lauren E, Cox, Shannon L, Palsson-McDermott, Eva, Finlay, David K, Vincent, Emma E, Jones, Nicholas, Curtis, Annie M

“…The transcription factor BMAL1 is a clock protein that generates daily or circadian rhythms in physiological functions including the inflammatory response of…”
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A Trial of Intrapleural Adenoviral-mediated Interferon-α2b Gene Transfer for Malignant Pleural Mesothelioma by STERMAN, Daniel H, HAAS, Andrew, PAPASAWAS, Emmanouil, MONTANER, Luis J, HEITJAN, Daniel F, LITZKY, Leslie, FRIEDBERG, Joseph, CULLIGAN, Melissa, JUNE, Carl H, CARROLL, Richard G, ALBELDA, Steven M, MOON, Edmund, RECIO, Adriana, SCHWED, Daniel, VACHANI, Anil, KATZ, Sharyn I, GILLESPIE, Colin T, GUANJUN CHENG, JING SUN

“…New therapeutic strategies are needed for malignant pleural mesothelioma (MPM). We conducted a single-center, open-label, nonrandomized, pilot and feasibility…”
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A Phase I Clinical Trial of Single-Dose Intrapleural IFN-β Gene Transfer for Malignant Pleural Mesothelioma and Metastatic Pleural Effusions: High Rate of Antitumor Immune Responses by STERMAN, Daniel H, RECIO, Adri, CORBLEY, Michael J, PARR, Michael, HO, Mitchell, PASTAN, Ira, MACHUZAK, Michael, BENEDICT, William, ZHANG, Xin-Qiao, LORD, Elaina M, LITZKY, Leslie A, HEITJAN, Daniel F, CARROLL, Richard G, JUNE, Carl H, KAISER, Larry R, VONDERHEIDE, Robert H, ALBELDA, Steven M, GILLESPIE, Colin T, HAAS, Andrew, VACHANI, Anil, KAPOOR, Veena, JING SUN, HODINKA, Richard, BROWN, Jennifer L

“…Purpose: This phase 1 dose escalation study evaluated the safety and feasibility of single-dose intrapleural IFN-β gene transfer using an adenoviral vector…”
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Vascular leukocytes contribute to tumor vascularization by Conejo-Garcia, Jose R., Buckanovich, Ronald J., Benencia, Fabian, Courreges, Maria C., Rubin, Stephen C., Carroll, Richard G., Coukos, George

“…There is no proof that hematopoietic cells contribute significantly to vasculogenesis in postnatal life. Here we report a novel leukocyte subset within ovarian…”
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Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells by Carroll, Richard G, Carpenito, Carmine, Shan, Xiaochuan, Danet-Desnoyers, Gwenn, Liu, Ronghua, Jiang, Shuguang, Albelda, Steven M, Golovina, Tatiana, Coukos, George, Riley, James L, Jonak, Zdenka L, June, Carl H

“…IL-18 has pleotropic effects on the activation of T cells during antigen presentation. We investigated the effects of human IL-18 on the engraftment and…”
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Immunosurveillance and Survivin-Specific T-Cell Immunity in Children With High-Risk Neuroblastoma by COUGHLIN, Christina M, FLEMING, Mark D, WEXLER, Michael H, DANET-DESNOYERS, Gwenn-Aël H, PINKUS, Jack L, PINKUS, Geraldine S, MARIS, John M, GRUPP, Stephan A, VONDERHEIDE, Robert H, CARROLL, Richard G, PAWEL, Bruce R, HOGARTY, Michael D, XIAOCHUAN SHAN, VANCE, Barbara A, COHEN, Jarish N, JAIRAJ, Sonya, LORD, Elaina M

“…Tumor immunosurveillance influences oncogenesis and tumor growth, but it remains controversial whether clinical failure of immunosurveillance is a result of…”
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Inflammasome Priming in Sterile Inflammatory Disease by Patel, Meghana N, Carroll, Richard G, Galván-Peña, Silvia, Mills, Evanna L, Olden, Robin, Triantafilou, Martha, Wolf, Amaya I, Bryant, Clare E, Triantafilou, Kathy, Masters, Seth L

“…The inflammasome is a cytoplasmic protein complex that processes interleukins (IL)-1β and IL-18, and drives a form of cell death known as pyroptosis…”
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Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2 by Early, James O., Menon, Deepthi, Wyse, Cathy A., Cervantes-Silva, Mariana P., Zaslona, Zbigniew, Carroll, Richard G., Palsson-McDermott, Eva M., Angiari, Stefano, Ryan, Dylan G., Corcoran, Sarah E., Timmons, George, Geiger, Sarah S., Fitzpatrick, Darren J., O’Connell, Daniel, Xavier, Ramnik J., Hokamp, Karsten, O’Neill, Luke A. J., Curtis, Annie M.

“…A variety of innate immune responses and functions are dependent on time of day, and many inflammatory conditions are associated with dysfunctional molecular…”
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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 by Mills, Evanna L., Ryan, Dylan G., Prag, Hiran A., Dikovskaya, Dina, Menon, Deepthi, Zaslona, Zbigniew, Jedrychowski, Mark P., Costa, Ana S. H., Higgins, Maureen, Hams, Emily, Szpyt, John, Runtsch, Marah C., King, Martin S., McGouran, Joanna F., Fischer, Roman, Kessler, Benedikt M., McGettrick, Anne F., Hughes, Mark M., Carroll, Richard G., Booty, Lee M., Knatko, Elena V., Meakin, Paul J., Ashford, Michael L. J., Modis, Louise K., Brunori, Gino, Sévin, Daniel C., Fallon, Padraic G., Caldwell, Stuart T., Kunji, Edmund R. S., Chouchani, Edward T., Frezza, Christian, Dinkova-Kostova, Albena T., Hartley, Richard C., Murphy, Michael P., O’Neill, Luke A.

“…WebTreatment of lipopolysaccharide-activated macrophages with the cell-permeable itaconate derivative 4-octyl itaconate activates the anti-inflammatory…”
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PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells by Goncharova, Elena A, Ammit, Alaina J, Irani, Carla, Carroll, Richard G, Eszterhas, Andrew J, Panettieri, Reynold A, Krymskaya, Vera P

“…Human vascular smooth muscle cell proliferation and migration contribute to vascular remodeling in pulmonary hypertension and atherosclerosis. The precise…”
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Aging alters rhythms in immunity by Curtis, Annie M., Carroll, Richard G.

“…A new study shows that the transcription factor KLF4 has a role in the maintenance of circadian immune responses. Loss of KLF4 activity contributes to the…”
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Regulatory T cells and cytokines in malignant pleural effusions secondary to mesothelioma and carcinoma by DeLong, Peter, Carroll, Richard G., Henry, Adam C., Tanaka, Tomoyuki, Ahmad, Sajjad, Leibowitz, Michael S., Sterman, Daniel H., June, Carl H., Albelda, Steven M., Vonderheide, Robert

“…Immunotherapy against a variety of malignancies, including pleural-based malignancies, has shown promise in animal models and early human clinical trials, but…”
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Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo by Milone, Michael C., Fish, Jonathan D., Carpenito, Carmine, Carroll, Richard G., Binder, Gwendolyn K., Teachey, David, Samanta, Minu, Lakhal, Mehdi, Gloss, Brian, Danet-Desnoyers, Gwenn, Campana, Dario, Riley, James L., Grupp, Stephan A., June, Carl H.

“…Persistence of T cells engineered with chimeric antigen receptors (CARs) has been a major barrier to use of these cells for molecularly targeted adoptive…”
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