Search Results - "Carroll, Mary J"

Evidence for dynamics in proteins as a mechanism for ligand dissociation by Carroll, Mary J, Mauldin, Randall V, Gromova, Anna V, Singleton, Scott F, Collins, Edward J, Lee, Andrew L

“…NMR and structural analyses of DHFR complexes with inhibitors of differing affinities define a model for ligand dissociation involving conformational switching…”
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Dynamic Dysfunction in Dihydrofolate Reductase Results from Antifolate Drug Binding: Modulation of Dynamics within a Structural State by Mauldin, Randall V., Carroll, Mary J., Lee, Andrew L.

“…The arduous task of rationally designing small-molecule enzyme inhibitors is complicated by the inherent flexibility of the protein scaffold. To gain insight…”
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Direct Detection of Structurally Resolved Dynamics in a Multiconformation Receptor−Ligand Complex by Carroll, Mary J, Gromova, Anna V, Miller, Keith R, Tang, Hao, Wang, Xiang Simon, Tripathy, Ashutosh, Singleton, Scott F, Collins, Edward J, Lee, Andrew L

“…Structure-based drug design relies on static protein structures despite significant evidence for the need to include protein dynamics as a serious…”
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Use of 73Ge NMR Spectroscopy for the Study of Electronic Interactions by Yoder, Claude H, Agee, Tamara M, Schaeffer, Charles D, Carroll, Mary J, Fleisher, Adam J, DeToma, Alaina S

“…The lack of understanding of the structural and electronic factors that affect the often difficult to observe germanium resonance has been a major deterrent to…”
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Direct detection of structurally resolved dynamics in a multi-conformation receptor-ligand complex by Carroll, Mary J., Gromova, Anna V., Miller, Keith R., Tang, Hao, Wang, Xiang Simon, Tripathy, Ashutosh, Singleton, Scott F., Collins, Edward J., Lee, Andrew L.

“…Structure-based drug design relies on static protein structures despite significant evidence for the need to include protein dynamics as a serious…”
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Use of 73 Ge NMR Spectroscopy and X-ray Crystallography for the Study of Electronic Interactions in Substituted Tetrakis(phenyl)-, -(phenoxy)-, and -(thiophenoxy)germanes by Yoder, Claude H., Agee, Tamara M., Griffith, Allison K., Schaeffer, Charles D., Carroll, Mary J., DeToma, Alaina S., Fleisher, Adam J., Gettel, Cameron J., Rheingold, Arnold L.

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Use of 73 Ge NMR Spectroscopy for the Study of Electronic Interactions by Yoder, Claude H., Agee, Tamara M., Schaeffer, Charles D., Carroll, Mary J., Fleisher, Adam J., DeToma, Alaina S.

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Probing the Dynamics of Dihydrofolate Reductase with Small Molecule Inhibitors by Carroll, Mary J

“…High-resolution protein crystal structures have served as the template from which to devise small molecule modulators of protein function through…”
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The lived experience of being in a sacred place constructed as an archetypal circle by Carroll, Mary J. (Jan)

“…The purpose of this study is to understand the meaning of women's lived experiences of major archetypes revealed through a "walk about" journey around the…”
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Probing the Dynamics of Dihydrofolate Reductase with Small Molecule Inhibitors by Carroll, Mary J

“…High-resolution protein crystal structures have served as the template from which to devise small molecule modulators of protein function through…”
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Use of 73Ge NMR Spectroscopy and X-ray Crystallography for the Study of Electronic Interactions in Substituted Tetrakis(phenyl)-, -(phenoxy)-, and -(thiophenoxy)germanes by Yoder, Claude H, Agee, Tamara M, Griffith, Allison K, Schaeffer, Charles D, Carroll, Mary J, DeToma, Alaina S, Fleisher, Adam J, Gettel, Cameron J, Rheingold, Arnold L

“…NMR chemical shifts of 1H, 13C, and 73Ge, molecular modeling, and single-crystal X-ray diffraction results are reported for a series of substituted tris- and…”
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