Saccharomyces cerevisiae Fermentation Products That Mitigate Foodborne Salmonella in Cattle and Poultry

Prior studies revealed that yeast fermentation products, specifically XPC™ and related products (Diamond V, Cedar Rapids, IA), serve as viable food safety tools across multiple food animal species including cattle and poultry. Providing this supplement in feed leads to reduced prevalence, load, viru...

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Bibliographic Details
Published in:	Frontiers in veterinary science Vol. 6; p. 107
Main Authors:	Feye, Kristina M, Carroll, Jasmine P, Anderson, Kristi L, Whittaker, John H, Schmidt-McCormack, Garrett R, McIntyre, Don R, Pavlidis, Hilary O, Carlson, Steve A
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 10-04-2019
Subjects:	antibiotic resistance food safety Salmonella Veterinary Science virulence yeast fermentation products food safety Salmonella yeast fermentation products virulence antibiotic resistance
Online Access:	Get full text
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Summary:	Prior studies revealed that yeast fermentation products, specifically XPC™ and related products (Diamond V, Cedar Rapids, IA), serve as viable food safety tools across multiple food animal species including cattle and poultry. Providing this supplement in feed leads to reduced prevalence, load, virulence, and antibiotic resistance of foodborne pathogens such as and O157:H7. These findings are worthy of further study, especially when coupled with the enhanced growth and performance observed with these products. Mechanistically, XPC appears to modulate these effects through the immune system and gut microbiome. Herein we further investigated this product and demonstrate that XPC mediates an enhancement of immunocyte killing of in calves fed the product. Additionally, these studies reveal that XPC reduces the lymph node infiltration, invasiveness, and antibiotic resistance of in dairy calves fed the product-consistent with findings observed in poultry and adult beef cattle. Furthermore, the reduction in invasiveness does not lead to a rebound hyperinvasive phenotype in obtained from XPC-fed animals. In summary, these studies suggest that XPC reduces the invasion of and may alter various phenotypic characteristics of the pathogen.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Lisa Bielke, The Ohio State University, United States; Yves Millemann, École Nationale Vétérinaire d'Alfort, France This article was submitted to Veterinary Infectious Diseases, a section of the journal Frontiers in Veterinary Science Edited by: Wageha Awad, University of Veterinary Medicine Vienna, Austria
ISSN:	2297-1769 2297-1769
DOI:	10.3389/fvets.2019.00107