Search Results - "Carroll, Graeme J."

Undetectable mannose binding lectin confers increased risk for serious infection in rheumatoid arthritis by Carroll, Graeme J

“…Physical activity and psychosomatic status in patients with Behçet's disease during coronavirus disease pandemic…”
Get full text

Undetectable mannose binding lectin is associated with HRCT proven bronchiectasis in rheumatoid arthritis (RA) by Makin, Krista, Easter, Tracie, Kemp, Monica, Kendall, Peter, Bulsara, Max, Coleman, Sophie, Carroll, Graeme J

“…The aim of this study was to ascertain whether mannose binding lectin deficiency is implicated in coexistent rheumatoid arthritis and bronchiectasis and to…”
Get full text

Interleukin-6 subfamily cytokines and rheumatoid arthritis: Role of antagonists by Jazayeri, Jalal A., Carroll, Graeme J., Vernallis, Ann B.

“…Many cytokines have been implicated in the inflammatory pathways that characterize rheumatoid arthritis (RA) and related inflammatory diseases of the joints…”
Get full text

Long-term Clinical Outcomes in Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome by Yap, Francis H.X., Olsson-White, Deborah, Roddy, Janet, Cook, Nicola J., Langlands, D. Robert, Manners, Prue J., Carroll, Graeme J.

“…To assess the outcome of empirical therapeutic interventions for synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. The clinical…”
Get full text

Undetectable Mannose Binding Lectin and Corticosteroids Increase Serious Infection Risk in Rheumatoid Arthritis by Carroll, Graeme J., MD, Makin, Krista, MBBS, Garnsey, Maxine, MBBS, Bulsara, Max, PhD, Carroll, Bronwyn V., MBBS, Curtin, Shona M., MBBS, Allan, Erin M., BEng, McLean-Tooke, Andrew, MD, Bundell, Christine, PhD, Kemp, Monica L., MSc, Deshpande, Pooja, MSc, Ihdayhid, Dana, MBBS, Coleman, Sophie, PhD, Easter, Tracie, MSc, Triplett, James, MMed, Disteldorf, Timothy, MBBS, Marsden, C. Helen, MSc, Lucas, Michaela, MD

“…Background Infection is the leading cause of death in rheumatoid arthritis (RA). Corticosteroid (CS) use is a known and important risk factor for serious…”
Get full text

Undetectable mannose binding lectin confers increased risk for serious infection in rheumatoid arthritis by Carroll, Graeme J

Get full text

HFE gene mutations are associated with osteoarthritis in the index or middle finger metacarpophalangeal joints by CARROLL, Graeme J

“…OBJECTIVE:. To test the hypothesis that possession of either C282Y or H63D mutations in the HFE gene is associated with primary osteoarthritis (OA) in joints…”
Get full text

Fc-Based Cytokines: Prospects for Engineering Superior Therapeutics by Jazayeri, Jalal A., Carroll, Graeme J.

“…The application of Fc (fragment crystallizable)-based cytokines (the fusion of the constant region of IgG to a cytokine of interest) as biotherapeutic agents…”
Get full text

The effectiveness of pulsed electrical stimulation (E-PES) in the management of osteoarthritis of the knee: a protocol for a randomised controlled trial by Fary, Robyn E, Carroll, Graeme J, Briffa, Tom G, Gupta, Ritu, Briffa, N Kathryn

“…Osteoarthritis (OA) of the knee is one of the main causes of musculoskeletal disability in the western world. Current available management options provide…”
Get full text

The effectiveness of pulsed electrical stimulation in the management of osteoarthritis of the knee: Results of a double‐blind, randomized, placebo‐controlled, repeated‐measures trial by Fary, Robyn E., Carroll, Graeme J., Briffa, Tom G., Briffa, N. K.

“…Objective To determine the effectiveness of subsensory, pulsed electrical stimulation (PES) in the symptomatic management of osteoarthritis (OA) of the knee…”
Get full text

Precocious bilateral hip joint osteoarthritis is a “form-fruste” of the arthropathy of Hereditary Haemochromatosis by Carroll, Graeme J

“…Summary Osteoarthritis (OA) of the hip joint is a common disorder, especially in aging peoples of Caucasian descent. Hip OA like OA in other joints is…”
Get full text

Role of a LIF antagonist in LIF and OSM induced MMP-1, MMP-3, and TIMP-1 expression by primary articular chondrocytes by Upadhyay, Aradhana, Sharma, Gaurav, Kivivuori, Satu, Raye, Warren S., Zabihi, Ebrahim, Carroll, Graeme J., Jazayeri, Jalal A.

“…Cartilage degradation is mediated by matrix metalloproteinases (MMPs) and their inhibitors, tissue metalloproteinases (TIMPs), which are transcriptionally…”
Get full text

Primary Osteoarthritis in the Ankle Joint Is Associated With Finger Metacarpophalangeal Osteoarthritis and the H63D Mutation in the HFE Gene: Evidence for a Hemochromatosis-Like Polyarticular Osteoarthritis Phenotype by Carroll, Graeme J

“…BACKGROUND AND AIM:Osteoarthritis (OA) can occur in the ankle joint. It also occurs in an appreciable proportion of subjects with hereditary hemochromatosis…”
Get full text

Targeting the glycoprotein 130 receptor subunit to control pain and inflammation by Jazayeri, Jalal A, Upadhyay, Aradhana, Vernallis, Ann B, Carroll, Graeme J

“…The glycoprotein 130 (gp130) is a shared signal-transducing-membrane-associated receptor for several hematopoietic cytokines. Its activation is implicated in…”
Get more information

Polyarticular osteoarthritis – Two major phenotypes hypothesized by Carroll, Graeme J.

“…Osteoarthritis is the commonest form of arthritis, at least amongst Caucasians and is frequently polyarticular. Genetic factors are now considered pivotal in…”
Get full text

In vitro evaluation of leukemia inhibitory factor receptor antagonists as candidate therapeutics for inflammatory arthritis by Jazayeri, Jalal A, De Weerd, Nicole, Raye, Warren, Kivivuori, Satu, Zabihi, Ebrahim, Carroll, Graeme J

“…Leukemia inhibitory factor (LIF) and oncostatin M (OSM) are found in appreciable concentrations in synovial fluid from patients with rheumatoid arthritis (RA)…”
Get more information

Generation of mutant leukaemia inhibitory factor (LIF)–IgG heavy chain fusion proteins as bivalent antagonists of LIF by Jazayeri, Jalal A., De Weerd, Nicole, Raye, Warren, Velkov, Tony, Santos, Lanie, Taylor, David, Carroll, Graeme J.

“…Two leukaemia inhibitory factor (LIF) mutants, designated MH35-BD and LIF05, have been shown to have a capacity to inhibit the biological activities of not…”
Get full text

Rheumatoid synovial fluid contains bioactive leukemia inhibitory factor with cartilage degrading activity--another target for chondroprotective intervention by Bell, M C, Carroll, G J

“…To determine if the procatabolic activity of inflammatory synovial fluids (SF) from patients with rheumatoid arthritis (RA) could be attenuated by the cytokine…”
Get more information

Leukemia inhibitory factor (LIF) binding protein attenuates the phlogistic and abolishes the chondral effects of LIF in goat joints by Bell, M, Carroll, G J, Chapman, H, Layton, M, Mills, J

“…To investigate the ability of murine leukemia inhibitory factor (LIF) binding protein (mLBP) to attenuate the effects of recombinant human LIF (rhLIF) in goat…”
Get more information

MODULATION OF CARTILAGE PROTEOGLYCAN METABOLISM BY LIF BINDING PROTEIN by Hui, Wang, Bell, Michael C., Carroll, Graeme J., Layton, Meredith J.

“…Leukaemia inhibitory factor (LIF) and oncostatin M (OSM) exhibit pleiotropic biological activities, share many structural and genetic features and bind with…”
Get full text