Search Results - "Carroll, Chris L"

Discovery of IPN60090, a Clinical Stage Selective Glutaminase‑1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties by Soth, Michael J, Le, Kang, Di Francesco, Maria Emilia, Hamilton, Matthew M, Liu, Gang, Burke, Jason P, Carroll, Chris L, Kovacs, Jeffrey J, Bardenhagen, Jennifer P, Bristow, Christopher A, Cardozo, Mario, Czako, Barbara, de Stanchina, Elisa, Feng, Ningping, Garvey, Jill R, Gay, Jason P, Do, Mary K. Geck, Greer, Jennifer, Han, Michelle, Harris, Angela, Herrera, Zachary, Huang, Sha, Giuliani, Virginia, Jiang, Yongying, Johnson, Sarah B, Johnson, Troy A, Kang, Zhijun, Leonard, Paul G, Liu, Zhen, McAfoos, Timothy, Miller, Meredith, Morlacchi, Pietro, Mullinax, Robert A, Palmer, Wylie S, Pang, Jihai, Rogers, Norma, Rudin, Charles M, Shepard, Hannah E, Spencer, Nakia D, Theroff, Jay, Wu, Qi, Xu, Alan, Yau, Ju Anne, Draetta, Giulio, Toniatti, Carlo, Heffernan, Timothy P, Jones, Philip

“…Inhibition of glutaminase-1 (GLS-1) hampers the proliferation of tumor cells reliant on glutamine. Known glutaminase inhibitors have potential limitations, and…”
Get full text

Synthesis and Cytotoxicity of Novel Sansalvamide A Derivatives by Carroll, Chris L, Johnston, Jennifer V. C, Kekec, Ahmet, Brown, Joseph D, Parry, Emily, Cajica, Julia, Medina, Irene, Cook, Kristina M, Corral, Ricardo, Pan, Po-Shen, McAlpine, Shelli R

“…Described are the syntheses of 14 derivatives of the natural product Sansalvamide A, where two are more active against HCT 116 colon cancer cell lines than the…”
Get full text

Synthesis of Sansalvamide A derivatives and their cytotoxicity in the MSS colon cancer cell line HT-29 by Styers, Thomas J., Kekec, Ahmet, Rodriguez, Rodrigo, Brown, Joseph D., Cajica, Julia, Pan, Po-Shen, Parry, Emily, Carroll, Chris L., Medina, Irene, Corral, Ricardo, Lapera, Stephanie, Otrubova, Katerina, Pan, Chung-Mao, McGuire, Kathleen L., McAlpine, Shelli R.

“…We report the synthesis of thirty-six Sansalvamide A derivatives, and their biological activity against colon cancer HT-29 cell line, a microsatellite stable…”
Get full text

Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC by Pan, Po-Shen, Curtis, Fiona A., Carroll, Chris L., Medina, Irene, Liotta, Lisa A., Sharples, Gary J., McAlpine, Shelli R.

“…Macrocyclic hexa- and octapeptides designed to trap Holliday junctions Holliday junctions (HJs) are formed as transient DNA intermediates during site-specific…”
Get full text

Synthesis and Cytotoxicity of Novel Sansalvamide A Derivatives by Carroll, Chris L, Johnston, Jennifer V. C, Kekec, Ahmet, Brown, Joseph D, Parry, Emily, Cajica, Julia, Medina, Irene, Cook, Kristina M, Corral, Ricardo, Pan, Po-Shen, McAlpine, Shelli R

Get full text

Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions by Liotta, Lisa A., Medina, Irene, Robinson, Jennifer L., Carroll, Chris L., Pan, Po-Shen, Corral, Ricardo, Johnston, Jennifer V.C., Cook, Kristina M., Curtis, Fiona A., Sharples, Gary J., McAlpine, Shelli R.

“…[Display omitted] Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and…”
Get full text