Search Results - "Carrithers, Michael D"

Update on Disease-Modifying Treatments for Multiple Sclerosis by Carrithers, Michael D., MD, PhD

“…Abstract Purpose The purpose of this review is to discuss the selection and use of disease- modifying treatments for patients with relapsing forms of multiple…”
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Differential DNA methylation associated with multiple sclerosis and disease modifying treatments in an underrepresented minority population by Bingen, Jeremy M, Clark, Lindsay V, Band, Mark R, Munzir, Ilyas, Carrithers, Michael D

“…Black and Hispanic American patients frequently develop earlier onset of multiple sclerosis (MS) and a more severe disease course that can be resistant to…”
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Inter-rater agreement for the annotation of neurologic signs and symptoms in electronic health records by Oommen, Chelsea, Howlett-Prieto, Quentin, Carrithers, Michael D, Hier, Daniel B

“…The extraction of patient signs and symptoms recorded as free text in electronic health records is critical for precision medicine. Once extracted, signs and…”
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Regulation of Podosome Formation in Macrophages by a Splice Variant of the Sodium Channel SCN8A by Carrithers, Michael D., Chatterjee, Gouri, Carrithers, Lisette M., Offoha, Roosevelt, Iheagwara, Uzoma, Rahner, Christoph, Graham, Morven, Waxman, Stephen G.

“…Voltage-gated sodium channels initiate electrical signaling in excitable cells such as muscle and neurons. They also are expressed in non-excitable cells such…”
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The visualization of Orphadata neurology phenotypes by Hier, Daniel B, Yelugam, Raghu, Carrithers, Michael D, Wunsch, 3rd, Donald C

“…Disease phenotypes are characterized by signs (what a physician observes during the examination of a patient) and symptoms (the complaints of a patient to a…”
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Current immunotherapy of multiple sclerosis and future challenges: relevance of immune-mediated repair by Carrithers, Michael D

“…Multiple sclerosis is the most common chronic inflammatory disease of the central nervous system and can cause severe neurological disability. Current immune…”
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Editorial: The digitalization of neurology by Hier, Daniel B, Carrithers, Michael D, Rodríguez-Fernández, Jorge M, Kummer, Benjamin

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Epithelial V-like antigen mediates efficacy of anti-alpha₄ integrin treatment in a mouse model of multiple sclerosis by Wright, Erik, Rahgozar, Kusha, Hallworth, Nicholas, Lanker, Stefan, Carrithers, Michael D

“…Natalizumab inhibits the transmigration of activated T lymphocytes into the brain and is highly efficacious in multiple sclerosis (MS). However, from a…”
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Subtypes of relapsing-remitting multiple sclerosis identified by network analysis by Howlett-Prieto, Quentin, Oommen, Chelsea, Carrithers, Michael D, Wunsch, 2nd, Donald C, Hier, Daniel B

“…We used network analysis to identify subtypes of relapsing-remitting multiple sclerosis subjects based on their cumulative signs and symptoms. The electronic…”
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Regulation of expansion of CD11c+ B cells and anti-viral immunity by epithelial V-like antigen by Dungan, Matthew, Carrithers, Michael D.

“…Prior work demonstrated that epithelial V-like antigen (EVA), a cell surface adhesion molecule, is expressed in B lymphocytes and is necessary for the efficacy…”
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Human Macrophage SCN5A Activates an Innate Immune Signaling Pathway for Antiviral Host Defense by Jones, Alexis, Kainz, Danielle, Khan, Faatima, Lee, Cara, Carrithers, Michael D.

“…Pattern recognition receptors contain a binding domain for pathogen-associated molecular patterns coupled to a signaling domain that regulates transcription of…”
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Activation of human macrophage sodium channels regulates RNA processing to increase expression of the DNA repair protein PPP1R10 by White, Chelsea R., Dungan, Matthew, Carrithers, Michael D.

“…Prior work demonstrated that a splice variant of SCN5A, a voltage-gated sodium channel gene, acts as a cytoplasmic sensor for viral dsRNA in human macrophages…”
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A sodium channel variant in Aedes aegypti as a candidate pathogen sensor for viral-associated molecular patterns by Lee, Cara, Jones, Alexis, Kainz, Danielle, Khan, Faatima, Carrithers, Michael D.

“…Recent work demonstrated that a splice variant of a human macrophage voltage-gated sodium channel expressed on endosomes acts as an intracellular sensor for…”
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Pearls & Oy-sters: A rare presentation of chronic intracranial hypertension with concurrent deafness and blindness by Bahr Hosseini, Mersedeh, Stone McGuire, Laura, Stosic, Milena, Moss, Heather E, Carrithers, Michael D

“…Isolated elevated intracranial pressure (ICP) classically presents with headache and papilledema without focal neurologic signs. super(1) Cranial nerve…”
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Mediation of Protection and Recovery From Experimental Autoimmune Encephalomyelitis by Macrophages Expressing the Human Voltage-Gated Sodium Channel NaV1.5 by Rahgozar, Kusha, Wright, Erik, Carrithers, Lisette M, Carrithers, Michael D

“…ABSTRACTMultiple sclerosis (MS) is the most common nontraumatic cause of neurologic disability in young adults. Despite treatment, progressive tissue injury…”
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Innate immune viral recognition: relevance to CNS infections by Carrithers, Michael D

“…Innate immune responses mediated by mononuclear phagocytes represent the initial host response to acute viral infection. PRRs, including TLRs, retinoic…”
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Expression of the Voltage-Gated Sodium Channel NaV1.5 in the Macrophage Late Endosome Regulates Endosomal Acidification by Carrithers, Michael D, Dib-Hajj, Sulayman, Carrithers, Lisette M, Tokmoulina, Gouzel, Pypaert, Marc, Jonas, Elizabeth A, Waxman, Stephen G

“…Voltage-gated sodium channels expressed on the plasma membrane activate rapidly in response to changes in membrane potential in cells with excitable membranes…”
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Characterization of epithelial V-like antigen in human choroid plexus epithelial cells: Potential role in CNS immune surveillance by Wojcik, Elise, Carrithers, Lisette M., Carrithers, Michael D.

“…► EVA is expressed by human choroid plexus epithelial cells and CD4 T lymphocytes. ► An anti-EVA antibody inhibits cell adhesion and epithelial calcium…”
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The human macrophage sodium channel NaV1.5 regulates mycobacteria processing through organelle polarization and localized calcium oscillations by Carrithers, Lisette M., Hulseberg, Paul, Sandor, Matyas, Carrithers, Michael D.

“…Abstract Phagocytosis and intracellular processing of mycobacteria by macrophages are complex cellular processes that require spatial and temporal coordination…”
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Diagnosis and management of multiple sclerosis: a handful of patience by Fleming, John O, Carrithers, Michael D

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