Search Results - "Carrion, Kelvin Carrasquillo"

Quantitative Proteomics Reveal That CB2R Agonist JWH-133 Downregulates NF-κB Activation, Oxidative Stress, and Lysosomal Exocytosis from HIV-Infected Macrophages by Rosario-Rodríguez, Lester J, Cantres-Rosario, Yadira M, Carrasquillo-Carrión, Kelvin, Rodríguez-De Jesús, Ana E, Cartagena-Isern, Luz J, García-Requena, Luis A, Roche-Lima, Abiel, Meléndez, Loyda M

“…HIV-associated neurocognitive disorders (HAND) affect 15-55% of HIV-positive patients and effective therapies are unavailable. HIV-infected monocyte-derived…”
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Toward the discovery of biological functions associated with the mechanosensor Mtl1p of Saccharomyces cerevisiae via integrative multi-OMICs analysis by Martínez-Matías, Nelson, Chorna, Nataliya, González-Crespo, Sahily, Villanueva, Lilliam, Montes-Rodríguez, Ingrid, Melendez-Aponte, Loyda M., Roche-Lima, Abiel, Carrasquillo-Carrión, Kelvin, Santiago-Cartagena, Ednalise, Rymond, Brian C., Babu, Mohan, Stagljar, Igor, Rodríguez-Medina, José R.

“…Functional analysis of the Mtl1 protein in Saccharomyces cerevisiae has revealed that this transmembrane sensor endows yeast cells with resistance to oxidative…”
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Plasma Proteins Associated with COVID-19 Severity in Puerto Rico by Rosario-Rodríguez, Lester J, Cantres-Rosario, Yadira M, Carrasquillo-Carrión, Kelvin, Rosa-Díaz, Alexandra, Rodríguez-De Jesús, Ana E, Rivera-Nieves, Verónica, Tosado-Rodríguez, Eduardo L, Méndez, Loyda B, Roche-Lima, Abiel, Bertrán, Jorge, Meléndez, Loyda M

“…Viral strains, age, and host factors are associated with variable immune responses against SARS-CoV-2 and disease severity. Puerto Ricans have a genetic…”
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DNA Methylation, Deamination, and Translesion Synthesis Combine to Generate Footprint Mutations in Cancer Driver Genes in B-Cell Derived Lymphomas and Other Cancers by Rogozin, Igor B., Roche-Lima, Abiel, Tyryshkin, Kathrin, Carrasquillo-Carrión, Kelvin, Lada, Artem G., Poliakov, Lennard Y., Schwartz, Elena, Saura, Andreu, Yurchenko, Vyacheslav, Cooper, David N., Panchenko, Anna R., Pavlov, Youri I.

“…Cancer genomes harbor numerous genomic alterations and many cancers accumulate thousands of nucleotide sequence variations. A prominent fraction of these…”
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Analysis of Sigma-1 Receptor Antagonist BD1047 Effect on Upregulating Proteins in HIV-1-Infected Macrophages Exposed to Cocaine Using Quantitative Proteomics by Vélez-López, Omar, Carrasquillo-Carrión, Kelvin, Cantres-Rosario, Yadira M, Machín-Martínez, Eraysy, Álvarez-Ríos, Manuel E, Roche-Lima, Abiel, Tosado-Rodríguez, Eduardo L, Meléndez, Loyda M

“…HIV-1 infects monocyte-derived macrophages (MDM) that migrate into the brain and secrete virus and neurotoxic molecules, including cathepsin B (CATB), causing…”
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Inhibition of Cathepsin B and SAPC Secreted by HIV-Infected Macrophages Reverses Common and Unique Apoptosis Pathways by Zenón-Meléndez, Camille N., Carrasquillo Carrión, Kelvin, Cantres Rosario, Yadira, Roche Lima, Abiel, Meléndez, Loyda M.

“…Human immunodeficiency virus 1 (HIV-1) infects blood monocytes that cross the blood–brain barrier to the central nervous system, inducing neuronal damage. This…”
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Paraoxonase-1 as a Cardiovascular Biomarker in Caribbean Hispanic Patients Treated with Clopidogrel: Abundance and Functionality by Monero-Paredes, Mariangeli, Santiago, Ednalise, Carrasquillo-Carrion, Kelvin, Renta, Jessicca Y, Rogozin, Igor B, Roche-Lima, Abiel, Duconge, Jorge

“…Clopidogrel, a prescription drug to reduce ischemic events in cardiovascular patients, has been extensively studied in mostly European individuals but not…”
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Local Ancestry‐Informed Candidate Pathway Analysis of Warfarin Stable Dose in Latino Populations by Steiner, Heidi E., Carrion, Kelvin Carrasquillo, Giles, Jason B., Lima, Abiel Roche, Yee, Kevin, Sun, Xiaoxiao, Cavallari, Larisa H., Perera, Minoli A., Duconge, Jorge, Karnes, Jason H.

“…Accuracy of warfarin dose prediction algorithms may be improved by including data from diverse populations in genetic studies of dose variability. Here, we…”
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Zika virus infection of the placenta alters extracellular matrix proteome by Borges-Vélez, Gabriel, Rosado-Philippi, Julio, Cantres-Rosario, Yadira M., Carrasquillo-Carrion, Kelvin, Roche-Lima, Abiel, Pérez-Vargas, Jean, González-Martínez, Andrea, Correa-Rivas, María S., Meléndez, Loyda M.

“…Zika virus (ZIKV) infection has been associated with fetal abnormalities by compromising placental integrity, but the mechanisms by which this occurs are…”
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Machine Learning Algorithm for Predicting Warfarin Dose in Caribbean Hispanics Using Pharmacogenetic Data by Roche-Lima, Abiel, Roman-Santiago, Adalis, Feliu-Maldonado, Roberto, Rodriguez-Maldonado, Jovaniel, Nieves-Rodriguez, Brenda G, Carrasquillo-Carrion, Kelvin, Ramos, Carla M, da Luz Sant'Ana, Istoni, Massey, Steven E, Duconge, Jorge

“…Despite some previous examples of successful application to the field of pharmacogenomics, the utility of machine learning (ML) techniques for warfarin dose…”
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Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells by Rabelo-Fernández, Robert J, Santiago-Sánchez, Ginette S, Sharma, Rohit K, Roche-Lima, Abiel, Carrion, Kelvin Carrasquillo, Rivera, Ricardo A Noriega, Quiñones-Díaz, Blanca I, Rajasekaran, Swetha, Siddiqui, Jalal, Miles, Wayne, Rivera, Yasmarie Santana, Valiyeva, Fatima, Vivas-Mejia, Pablo E

“…Worldwide, the number of cancer-related deaths continues to increase due to the ability of cancer cells to become chemotherapy-resistant and metastasize. For…”
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Antimalarial Drug Combination Predictions Using the Machine Learning Synergy Predictor (MLSyPred©) tool by Roche-Lima, Abiel, Rosado-Quiñones, Angélica M., Feliu-Maldonado, Roberto A., Figueroa-Gispert, María Del Mar, Díaz-Rivera, Jennifer, Díaz-González, Roberto G., Carrasquillo-Carrion, Kelvin, Nieves, Brenda G., Colón-Lorenzo, Emilee E., Serrano, Adelfa E.

“…Purpose Antimalarial drug resistance is a global public health problem that leads to treatment failure. Synergistic drug combinations can improve treatment…”
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Modelling and molecular docking studies of the cytoplasmic domain of Wsc-family, full-length Ras2p, and therapeutic antifungal compounds by Vélez-Segarra, Vladimir, Carrasquillo-Carrión, Kelvin, Santini-González, Jorge J., Ramos-Valerio, Yabdiel A., Vázquez-Quiñones, Luis E., Roche-Lima, Abiel, Rodríguez-Medina, José R., Parés-Matos, Elsie I.

“…[Display omitted] •Wsc-family is involved in protein-protein interactions with each other and with Ras2p.•Motif I of the cytoplasmic tail of the Wsc-family is…”
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The Presence of Genotoxic and/or Pro-inflammatory Bacterial Genes in Gut Metagenomic Databases and Their Possible Link With Inflammatory Bowel Diseases by Roche-Lima, Abiel, Carrasquillo-Carrión, Kelvin, Gómez-Moreno, Ramón, Cruz, Juan M, Velázquez-Morales, Dayanara M, Rogozin, Igor B, Baerga-Ortiz, Abel

“…The human gut microbiota is a dynamic community of microorganisms that mediate important biochemical processes. Differences in the gut microbial composition…”
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Hotspots of Sequence Variability in Gut Microbial Genes Encoding Pro-Inflammatory Factors Revealed by Oligotyping by Gómez-Moreno, Ramón, Martínez-Ramírez, Rachell, Roche-Lima, Abiel, Carrasquillo-Carrión, Kelvin, Pérez-Santiago, Josué, Baerga-Ortiz, Abel

“…The gut microbiota has been implicated in a number of normal and disease biological processes. Recent studies have identified a subset of gut bacterial genes…”
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Abstract 2180: Somatic mutation landscape in early-onset colorectal cancer tumors from hispanics by Gonzalez-Pons, Maria, Montes-Rodriguez, Ingrid, Carrasquillo-Carrion, Kelvin, Roche-Lima, Abiel, Singhal, Sandeep, Napoles, Anna M., Byun, Jung S., Perez-Stable, Eliseo, Gardner, Kevin, Cruz-Correa, Marcia

“…Background: In the last 40 years, the incidence of colorectal cancer (CRC) among individuals <50 years (early-onset CRC) has been increasing at an alarming…”
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Non-Random Enrichment of Single-Nucleotide Polymorphisms Associated with Clopidogrel Resistance within Risk Loci Linked to the Severity of Underlying Cardiovascular Diseases: The Role of Admixture by Monero-Paredes, Mariangeli, Feliu-Maldonado, Roberto, Carrasquillo-Carrion, Kelvin, Gonzalez, Pablo, Rogozin, Igor B, Roche-Lima, Abiel, Duconge, Jorge

“…Cardiovascular disease (CVD) is one of the leading causes of death in Puerto Rico, where clopidogrel is commonly prescribed to prevent ischemic events. Genetic…”
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Proteomics analysis to identify intracellular inflammatory pathways modulated by Fh15 in macrophages stimulated with LPS- E. coli by Armina-Rodriguez, Albersy, Valdés-Fernández, Bianca, Roche-Lima, Abiel, Carrasquillo-Carrión, Kelvin, Espino, Ana M

“…Previous studies of our laboratory have demonstrated that Fh15, the recombinant variant of F. hepatica FABP exhibit powerful anti-inflammatory properties. The…”
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Abstract 2124: Hotspots of sequence variability in gut microbial metagenomic datasets and their association with colorectal cancer by Martinez-Ramirez, Rachell M., Girod-Hoffman, Miguel M., Roche-Lima, Abiel, Carrasquillo-Carrión, Kelvin, Pérez-Santiago, Josué, Baerga-Ortiz, Abel

“…The gut microbiome has been found to impact host predisposition to disease. Previous research shows that certain species of microbes, encoding pro-inflammatory…”
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The Characterization of Monoclonal Antibodies to Mouse TLT-1 Suggests That TLT-1 Plays a Role in Wound Healing by Manfredi, Barbara, Morales-Ortíz, Jessica, Díaz-Díaz, Lymarie M, Hernandez-Matias, Liz, Barreto-Vázquez, Delmaliz, Menéndez-Pérez, Javier, Rodríguez-Cordero, J Alejandro, Villalobos-Santos, Juan C, Santiago-Rivera, Edgardo, Rivera-Dompenciel, Adriana, Lozada-Delgado, Eunice L, Kuchibhotla, Madhavi, Carrasquillo-Carrión, Kelvin, Roche-Lima, Abiel, Washington, A Valance

“…Platelets play a vital role in hemostasis and inflammation. The membrane receptor TREM-like transcript-1 (TLT-1) is involved in platelet aggregation, bleeding,…”
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