Search Results - "Carrington, Emma M."

Life and Death of Activated T Cells: How Are They Different from Naïve T Cells? by Zhan, Yifan, Carrington, Emma M, Zhang, Yuxia, Heinzel, Susanne, Lew, Andrew M

“…T cells are pivotal in immunity and immunopathology. After activation, T cells undergo a clonal expansion and differentiation followed by a contraction phase,…”
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GM‐CSF increases cross‐presentation and CD103 expression by mouse CD8+ spleen dendritic cells by Zhan, Yifan, Carrington, Emma M., van Nieuwenhuijze, Annemarie, Bedoui, Sammy, Seah, Shirley, Xu, Yuekang, Wang, Nancy, Mintern, Justine D., Villadangos, Jose A., Wicks, Ian P., Lew, Andrew M.

“…Resident CD8+ DCs perform several functions, including cross‐presenting antigen and rapidly engulfing the Gram‐positive intracellular pathogen Listeria…”
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GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function by Sun, Li, Rautela, Jai, Delconte, Rebecca B, Souza-Fonseca-Guimaraes, Fernando, Carrington, Emma M, Schenk, Robyn L, Herold, Marco J, Huntington, Nicholas D, Lew, Andrew M, Xu, Yuekang, Zhan, Yifan

“…GM-CSF promotes myeloid differentiation of cultured bone marrow cells into cells of the granulocytic and monocytic lineage; the latter can further…”
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Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells by Carrington, Emma M., Zhang, Jian-Guo, Sutherland, Robyn M., Vikstrom, Ingela B., Brady, Jamie L., Soo, Priscilla, Vremec, David, Allison, Cody, Lee, Erinna F., Fairlie, W. Douglas, Bouillet, Philippe, Grabow, Stephanie, Ottina, Eleonora, Herold, Marco J., Pellegrini, Marc, Huang, David C. S., Tarlinton, David M., Strasser, Andreas, Lew, Andrew M., Zhan, Yifan

“…Dendritic cells (DCs) are heterogeneous, comprising subsets with functional specializations that play distinct roles in immunity as well as immunopathology. We…”
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BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs by Carrington, Emma M., Vikstrom, Ingela B., Light, Amanda, Sutherland, Robyn M., Londrigan, Sarah L., Mason, Kylie D., Huang, David C. S., Lew, Andrew M., Tarlinton, David M., Nossal, Gustav J.

“…Death by apoptosis shapes tissue homeostasis. Apoptotic mechanisms are so universal that harnessing them for tailored immune intervention would seem…”
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The closely related CD103+ dendritic cells (DCs) and lymphoid-resident CD8+ DCs differ in their inflammatory functions by Jiao, Zhijun, Bedoui, Sammy, Brady, Jamie L, Walter, Anne, Chopin, Michael, Carrington, Emma M, Sutherland, Robyn M, Nutt, Stephen L, Zhang, Yuxia, Ko, Hyun-Ja, Wu, Li, Lew, Andrew M, Zhan, Yifan

“…Migratory CD103+ and lymphoid-resident CD8+ dendritic cells (DCs) share many attributes, such as dependence on the same transcription factors, cross-presenting…”
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Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ by Sutherland, Robyn M., Londrigan, Sarah L., Brady, Jamie L., Carrington, Emma M., Marchingo, Julia M., Heinzel, Susanne, Hodgkin, Philip D., Graham, Kate L., Kay, Thomas W., Zhan, Yifan, Lew, Andrew M.

“…T-cell responses are initiated upon cognate presentation by professional antigen presenting cells in lymphoid tissue. T cells then migrate to inflamed tissues,…”
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Monocyte-Derived Dendritic Cells Impair Early Graft Function following Allogeneic Islet Transplantation by Chow, Kevin V., Carrington, Emma M., Zhan, Yifan, Lew, Andrew M., Sutherland, Robyn M.

“…Islet transplantation can cure type 1 diabetes but is limited by lack of donor organs and early graft dysfunction, such that many patients require multiple…”
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Proapoptotic BH3-Only Protein Bid Is Essential For Death Receptor–Induced Apoptosis of Pancreatic β-Cells by MCKENZIE, Mark D, CARRINGTON, Emma M, KAUFMANN, Thomas, STRASSER, Andreas, HUANG, David C. S, KAY, Thomas W. H, ALLISON, Janette, THOMAS, Helen E

“…Proapoptotic BH3-Only Protein Bid Is Essential For Death Receptor–Induced Apoptosis of Pancreatic β-Cells Mark D. McKenzie 1 , Emma M. Carrington 1 , Thomas…”
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Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways by Zhan, Yifan, Xu, Yuekang, Seah, Shirley, Brady, Jamie L, Carrington, Emma M, Cheers, Christina, Croker, Ben A, Wu, Li, Villadangos, Jose A, Lew, Andrew M

“…IL-12 is such a pivotal cytokine that it has been called the third signal for T cell activation, TCR engagement being the first and costimulation being the…”
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Islet β-Cells Deficient in Bcl-xL Develop but Are Abnormally Sensitive to Apoptotic Stimuli by CARRINGTON, Emma M, MCKENZIE, Mark D, JANSEN, Elisa, MYERS, Michelle, FYNCH, Stacey, KOS, Cameron, STRASSER, Andreas, KAY, Thomas W, SCOTT, Clare L, ALLISON, Janette

“…Islet β-Cells Deficient in Bcl-xL Develop but Are Abnormally Sensitive to Apoptotic Stimuli Emma M. Carrington 1 , Mark D. McKenzie 2 , Elisa Jansen 3 ,…”
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Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity by Lai, Junyun, Mardiana, Sherly, House, Imran G., Sek, Kevin, Henderson, Melissa A., Giuffrida, Lauren, Chen, Amanda X. Y., Todd, Kirsten L., Petley, Emma V., Chan, Jack D., Carrington, Emma M., Lew, Andrew M., Solomon, Benjamin J., Trapani, Joseph A., Kedzierska, Katherine, Evrard, Maximilien, Vervoort, Stephin J., Waithman, Jason, Darcy, Phillip K., Beavis, Paul A.

“…Adoptive cell therapies using genetically engineered T cell receptor or chimeric antigen receptor T cells are emerging forms of immunotherapy that redirect T…”
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Rotavirus Infection of Infant and Young Adult Nonobese Diabetic Mice Involves Extraintestinal Spread and Delays Diabetes Onset by GRAHAM, Kate L, O'DONNELL, Joanne A, YAN TAN, SANDERS, Natalie, CARRINGTON, Emma M, ALLISON, Janette, COULSON, Barbara S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response by Seah, Shirley G. K., Brady, Jamie L., Carrington, Emma M., Ng, Wy Ching, Sutherland, Robyn M., Hancock, Manuela S., La Gruta, Nicole L., Brown, Lorena E., Turner, Stephen J., Lew, Andrew M., Zhan, Yifan

“…Direct costimulation of CD8+ T cells is more important than the canonical licensing of DCs by CD4 help, in influenza. The helper‐dependent pathway of priming…”
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Selective depletion of cross-presenting dendritic cells enhances islet allograft survival by Sutherland, Robyn M, Zhan, Yifan, Carrington, Emma M, Londrigan, Sarah L, Lew, Andrew M

“…MHC class I presentation of peptides derived from exogenous antigens (not synthesized within the antigen-presenting cell) is called cross-presentation and is…”
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Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo by Carrington, Emma M, Zhan, Yifan, Brady, Jamie L, Zhang, Jian-Guo, Sutherland, Robyn M, Anstee, Natasha S, Schenk, Robyn L, Vikstrom, Ingela B, Delconte, Rebecca B, Segal, David, Huntington, Nicholas D, Bouillet, Philippe, Tarlinton, David M, Huang, David CS, Strasser, Andreas, Cory, Suzanne, Herold, Marco J, Lew, Andrew M

“…Survival of various immune cell populations has been proposed to preferentially rely on a particular anti-apoptotic BCL-2 family member, for example, naive T…”
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Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment by Schenk, Robyn L, Tuzlak, Selma, Carrington, Emma M, Zhan, Yifan, Heinzel, Susanne, Teh, Charis E, Gray, Daniel H, Tai, Lin, Lew, Andrew M, Villunger, Andreas, Strasser, Andreas, Herold, Marco J

“…The pro-survival proteins of the BCL-2 family regulate the survival of all cells, and genetic deletion models for these proteins have revealed which specific…”
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The life and death of immune cell types: the role of BCL‐2 anti‐apoptotic molecules by Carrington, Emma M, Tarlinton, David M, Gray, Daniel H, Huntington, Nicholas D, Zhan, Yifan, Lew, Andrew M

“…Targeting survival mechanisms of immune cells may provide an avenue for immune intervention to dampen unwanted responses (e.g. autoimmunity, immunopathology…”
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Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes by Jiao, Yuhao, Davis, Joanne E., Rautela, Jai, Carrington, Emma M., Ludford-Menting, Mandy J., Goh, Wilford, Delconte, Rebecca B., Souza-Fonseca-Guimaraes, Fernando, Koldej, Rachel, Gray, Daniel, Huang, David, Kile, Ben T., Lew, Andrew M., Ritchie, David S., Huntington, Nicholas D.

“…Allogeneic hematopoietic stem cell transplantation (alloSCT) is used to treat over 15,000 patients with acute myeloid leukemia (AML) per year. Donor…”
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The inflammatory cytokine, GM‐CSF, alters the developmental outcome of murine dendritic cells by Zhan, Yifan, Vega‐Ramos, Javier, Carrington, Emma M., Villadangos, Jose A., Lew, Andrew M., Xu, Yuekang

“…Fms‐like tyrosine kinase 3 ligand (Flt3L) is a major cytokine that drives development of dendritic cells (DCs) under steady state, whereas GM‐CSF becomes a…”
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