Search Results - "Carrigy, Nicholas B."

Production of Inhalation Phage Powders Using Spray Freeze Drying and Spray Drying Techniques for Treatment of Respiratory Infections by Leung, Sharon S. Y., Parumasivam, Thaigarajan, Gao, Fiona G., Carrigy, Nicholas B., Vehring, Reinhard, Finlay, Warren H., Morales, Sandra, Britton, Warwick J., Kutter, Elizabeth, Chan, Hak-Kim

“…Purpose The potential of aerosol phage therapy for treating lung infections has been demonstrated in animal models and clinical studies. This work compared the…”
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Amorphous pullulan trehalose microparticle platform for respiratory delivery by Carrigy, Nicholas B., Ordoubadi, Mani, Liu, Yushan, Melhem, Omar, Barona, David, Wang, Hui, Milburn, Leanne, Ruzycki, Conor A., Finlay, Warren H., Vehring, Reinhard

“…[Display omitted] Spray drying biologics and small-molecule drugs can increase their thermal stability relative to liquid dosage forms and allow for widespread…”
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Trileucine and Pullulan Improve Anti-Campylobacter Bacteriophage Stability in Engineered Spray-Dried Microparticles by Carrigy, Nicholas B., Liang, Lu, Wang, Hui, Kariuki, Samuel, Nagel, Tobi E., Connerton, Ian F., Vehring, Reinhard

“…Spray drying biologics into a powder can increase thermal stability and shelf-life relative to liquid formulations, potentially eliminating the need for cold…”
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Spray-dried anti-Campylobacter bacteriophage CP30A powder suitable for global distribution without cold chain infrastructure by Carrigy, Nicholas B., Liang, Lu, Wang, Hui, Kariuki, Samuel, Nagel, Tobi E., Connerton, Ian F., Vehring, Reinhard

“…[Display omitted] Campylobacter jejuni is a leading cause of foodborne illness globally. In this study, a spray drying and packaging process was developed to…”
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Effects of storage conditions on the stability of spray dried, inhalable bacteriophage powders by Leung, Sharon S.Y., Parumasivam, Thaigarajan, Gao, Fiona G., Carter, Elizabeth A., Carrigy, Nicholas B., Vehring, Reinhard, Finlay, Warren H., Morales, Sandra, Britton, Warwick J., Kutter, Elizabeth, Chan, Hak-Kim

“…[Display omitted] This study aimed to develop inhalable powders containing phages active against antibiotic-resistant Pseudomonas aeruginosa for pulmonary…”
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Effect of storage temperature on the stability of spray dried bacteriophage powders by Leung, Sharon S.Y., Parumasivam, Thaigarajan, Nguyen, An, Gengenbach, Thomas, Carter, Elizabeth A., Carrigy, Nicholas B., Wang, Hui, Vehring, Reinhard, Finlay, Warren H., Morales, Sandra, Britton, Warwick J., Kutter, Elizabeth, Chan, Hak-Kim

“…[Display omitted] This study aimed to assess the robustness of using a spray drying approach and formulation design in producing inhalable phage powders. Two…”
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Microparticle encapsulation of a tuberculosis subunit vaccine candidate containing a nanoemulsion adjuvant via spray drying by Gomez, Mellissa, Archer, Michelle, Barona, David, Wang, Hui, Ordoubadi, Mani, Bin Karim, Shabab, Carrigy, Nicholas B., Wang, Zheng, McCollum, Joseph, Press, Chris, Gerhardt, Alana, Fox, Christopher B., Kramer, Ryan M., Vehring, Reinhard

“…[Display omitted] Spray drying is a technique that can be used to stabilize biopharmaceuticals, such as vaccines, within dry particles. Compared to liquid…”
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Atmospheric Spray Freeze Drying of Sugar Solution With Phage D29 by Ly, Alvin, Carrigy, Nicholas B, Wang, Hui, Harrison, Melissa, Sauvageau, Dominic, Martin, Andrew R, Vehring, Reinhard, Finlay, Warren H

“…Therapeutic bacteriophages offer a potential alternative approach in the treatment of drug resistant bacteria. In the present study, we examine the ability of…”
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Development and Testing of a Spray-Dried Tuberculosis Vaccine Candidate in a Mouse Model by Gomez, Mellissa, Ahmed, Mushtaq, Das, Shibali, McCollum, Joseph, Mellett, Leah, Swanson, Rosemary, Gupta, Ananya, Carrigy, Nicholas B, Wang, Hui, Barona, David, Bachchhav, Shital, Gerhardt, Alana, Press, Chris, Archer, Michelle C, Liang, Hong, Seydoux, Emilie, Kramer, Ryan M, Kuehl, Philip J, Vehring, Reinhard, Khader, Shabaana A, Fox, Christopher B

“…Converting a vaccine into a thermostable dry powder is advantageous as it reduces the resource burden linked with the cold chain and provides flexibility in…”
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Use of Extrathoracic Deposition Models for Patient-Specific Dose Estimation during Inhaler Design by Carrigy, Nicholas B, Martin, Andrew R, Finlay, Warren H

“…The lung dose of inhaled pharmaceutical aerosol that an individual will receive from an inhaler can now be more accurately estimated in light of recent…”
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Development of a Lyophilization Process for Campylobacter Bacteriophage Storage and Transport by Liang, Lu, Carrigy, Nicholas B, Kariuki, Samuel, Muturi, Peter, Onsare, Robert, Nagel, Tobi, Vehring, Reinhard, Connerton, Phillippa L, Connerton, Ian F

“…Bacteriophages are a sustainable alternative to control pathogenic bacteria in the post-antibiotic era. Despite promising reports, there are still obstacles to…”
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Formulation strategies for bacteriophages to target intracellular bacterial pathogens by Yan, Wei, Banerjee, Parikshit, Xu, Miao, Mukhopadhyay, Subhankar, Ip, Margaret, Carrigy, Nicholas B., Lechuga-Ballesteros, David, To, Kenneth Kin Wah, Leung, Sharon S.Y.

“…[Display omitted] Bacteriophages (Phages) are antibacterial viruses that are unaffected by antibiotic drug resistance. Many Phase I and Phase II phage therapy…”
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Development of a formulation platform for a spray-dried, inhalable tuberculosis vaccine candidate by Gomez, Mellissa, McCollum, Joseph, Wang, Hui, Ordoubadi, Mani, Jar, Chester, Carrigy, Nicholas B., Barona, David, Tetreau, Isobel, Archer, Michelle, Gerhardt, Alana, Press, Chris, Fox, Christopher B., Kramer, Ryan M., Vehring, Reinhard

“…[Display omitted] Protection against primarily respiratory infectious diseases, such as tuberculosis (TB), can likely be enhanced through mucosal immunization…”
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Prophylaxis of Mycobacterium tuberculosis H37Rv Infection in a Preclinical Mouse Model via Inhalation of Nebulized Bacteriophage D29 by Carrigy, Nicholas B, Larsen, Sasha E, Reese, Valerie, Pecor, Tiffany, Harrison, Melissa, Kuehl, Philip J, Hatfull, Graham F, Sauvageau, Dominic, Baldwin, Susan L, Finlay, Warren H, Coler, Rhea N, Vehring, Reinhard

“…Globally, more people die annually from tuberculosis than from any other single infectious agent. Unfortunately, there is no commercially-available vaccine…”
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Jet nebulization of bacteriophages with different tail morphologies – Structural effects by Leung, Sharon Shui Yee, Carrigy, Nicholas B., Vehring, Reinhard, Finlay, Warren H., Morales, Sandra, Carter, Elizabeth A., Britton, Warwick J., Kutter, Elizabeth, Chan, Hak-Kim

“…[Display omitted] It was previously demonstrated that the loss of infectivity of a myovirus PEV44 after jet nebulization was closely related to a change in…”
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Anti-Tuberculosis Bacteriophage D29 Delivery with a Vibrating Mesh Nebulizer, Jet Nebulizer, and Soft Mist Inhaler by Carrigy, Nicholas B., Chang, Rachel Y., Leung, Sharon S. Y., Harrison, Melissa, Petrova, Zaritza, Pope, Welkin H., Hatfull, Graham F., Britton, Warwick J., Chan, Hak-Kim, Sauvageau, Dominic, Finlay, Warren H., Vehring, Reinhard

“…Purpose To compare titer reduction and delivery rate of active anti-tuberculosis bacteriophage (phage) D29 with three inhalation devices. Methods Phage D29…”
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Trileucine as a dispersibility enhancer of spray-dried inhalable microparticles by Ordoubadi, Mani, Gregson, Florence K.A., Wang, Hui, Carrigy, Nicholas B., Nicholas, Mark, Gracin, Sandra, Lechuga-Ballesteros, David, Reid, Jonathan P., Finlay, Warren H., Vehring, Reinhard

“…The formation of trileucine-containing spray-dried microparticles intended for pulmonary delivery was studied in depth. A single-particle method was employed…”
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Pediatric in vitro and in silico models of deposition via oral and nasal inhalation by Carrigy, Nicholas B, Ruzycki, Conor A, Golshahi, Laleh, Finlay, Warren H

“…Respiratory tract deposition models provide a useful method for optimizing the design and administration of inhaled pharmaceutical aerosols, and can be useful…”
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Effect of facial material softness and applied force on face mask dead volume, face mask seal, and inhaled corticosteroid delivery through an idealized infant replica by Carrigy, Nicholas B, O'Reilly, Connor, Schmitt, James, Noga, Michelle, Finlay, Warren H

“…During the aerosol delivery device design and optimization process, in vitro lung dose (LD) measurements are often performed using soft face models, which may…”
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Simulation of muscle and adipose tissue deformation in the passive human pharynx by Carrigy, Nicholas B., Carey, Jason P., Martin, Andrew R., Remmers, John E., Zareian, Ali, Topor, Zbigniew, Grosse, Joshua, Noga, Michelle, Finlay, Warren H.

“…Quantifying the contribution of passive mechanical deformation in the human pharynx to upper airway collapse is fundamental to understanding the competing…”
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