Search Results - "Carrico, Isaac"

Light-Activated Staudinger–Bertozzi Ligation within Living Animals by Shah, Lisa, Laughlin, Scott T, Carrico, Isaac S

“…The ability to regulate small molecule chemistry in vivo will enable new avenues of exploration in imaging and pharmacology. However, realization of these…”
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Chemoselective modification of proteins: hitting the target by Carrico, Isaac S

“…The use of synthetic molecules to modulate and track biological events is a central component of chemical biology. As a result, the precise, covalent…”
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Unfolded states under folding conditions accommodate sequence-specific conformational preferences with random coil-like dimensions by Peran, Ivan, Holehouse, Alex S., Carrico, Isaac S., Pappu, Rohit V., Bilsel, Osman, Raleigh, Daniel P.

“…Proteins are marginally stable molecules that fluctuate between folded and unfolded states. Here, we provide a high-resolution description of unfolded states…”
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Introducing genetically encoded aldehydes into proteins by Bertozzi, Carolyn R, Carrico, Isaac S, Carlson, Brian L

“…Methods for introducing bioorthogonal functionalities into proteins have become central to protein engineering efforts. Here we describe a method for the…”
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Metabolic cross-talk allows labeling of O-linked β-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway by Boyce, Michael, Carrico, Isaac S, Ganguli, Anjali S, Yu, Seok-Ho, Hangauer, Matthew J, Hubbard, Sarah C, Kohler, Jennifer J, Bertozzi, Carolyn R

“…Hundreds of mammalian nuclear and cytoplasmic proteins are reversibly glycosylated by O-linked β-N-acetylglucosamine (O-GlcNAc) to regulate their function,…”
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Surface modification via strain-promoted click reaction facilitates targeted lentiviral transduction by Chu, Yanjie, Oum, Yoon Hyeun, Carrico, Isaac S

“…Abstract As a result of their ability to integrate into the genome of both dividing and non-dividing cells, lentiviruses have emerged as a promising vector for…”
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Unnatural Amino Acid Incorporation onto Adenoviral (Ad) Coat Proteins Facilitates Chemoselective Modification and Retargeting of Ad Type 5 Vectors by Banerjee, Partha Sarathi, Ostapchuk, Philomena, Hearing, Patrick, Carrico, Isaac Sheridan

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Altering Adenoviral Tropism via Click Modification with ErbB Specific Ligands by Oum, Yoon Hyeun, Carrico, Isaac S

“…Methods for targeting oncolytic viruses can increase efficacy and accelerate development. Genetic engineering, the predominant method for changing vector…”
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Azidohomoalanine: A Conformationally Sensitive IR Probe of Protein Folding, Protein Structure, and Electrostatics by Taskent-Sezgin, Humeyra, Chung, Juah, Banerjee, Partha S, Nagarajan, Sureshbabu, Dyer, R. Brian, Carrico, Isaac, Raleigh, Daniel P

“…Highly sensitive: The azido analogue of methionine, azidohomoalanine (see picture), is shown to be a sensitive IR probe of protein structure, folding, and…”
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Lithographic Patterning of Photoreactive Cell-Adhesive Proteins by Carrico, Isaac S, Maskarinec, Stacey A, Heilshorn, Sarah C, Mock, Marissa L, Liu, Julie C, Nowatzki, Paul J, Franck, Christian, Ravichandran, Guruswami, Tirrell, David A

“…We describe a novel, simple method for the photolithographic patterning of cell-adhesive proteins. Intrinsically photoreactive proteins are synthesized in…”
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Differential Ordering of the Protein Backbone and Side Chains during Protein Folding Revealed by Site-Specific Recombinant Infrared Probes by Nagarajan, Sureshbabu, Taskent-Sezgin, Humeyra, Parul, Dzmitry, Carrico, Isaac, Raleigh, Daniel P, Dyer, R. Brian

“…The time scale for ordering of the polypeptide backbone relative to the side chains is a critical issue in protein folding. The interplay between ordering of…”
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New frontiers in protein bioconjugation by Francis, Matthew B, Carrico, Isaac S

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Compartment-Specific Labeling of Bacterial Periplasmic Proteins by Peroxidase-Mediated Biotinylation by Ganapathy, Uday S., Bai, Lu, Wei, Linpeng, Eckartt, Kathryn A., Lett, Clarissa M., Previti, Mary L., Carrico, Isaac S., Seeliger, Jessica C.

“…The study of the bacterial periplasm requires techniques with sufficient spatial resolution and sensitivity to resolve the components and processes within this…”
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Targeted and armed oncolytic adenovirus via chemoselective modification by Banerjee, Partha S., Zuniga, Edison S., Ojima, Iwao, Carrico, Isaac S.

“…Oncolytic adenoviruses (Ads) are an emerging alternative therapy for cancer; however, clinical trial have not yet demonstrated sufficient efficacy. When…”
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Nanoparticles Designer labels for virus coats by Carrico, Isaac S, Kirshenbaum, Kent

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Biosynthesis of Proteins Incorporating a Versatile Set of Phenylalanine Analogues by Kirshenbaum, Kent, Carrico, Isaac S., Tirrell, David A.

“…Unnatural amino acids with useful chemical functionality can replace phenylalanine in bacterial proteins. Coexpression of a promiscuous phenylalanine‐tRNA…”
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Derivatives of 8-Hydroxy-2-methylquinoline Are Powerful Prototypes for Zinc Sensors in Biological Systems by Pearce, Dierdre A, Jotterand, Nathalie, Carrico, Isaac S, Imperiali, Barbara

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Chemoselective modification of viral surfaces via bioorthogonal click chemistry by Rubino, Frederick A, Oum, Yoon Hyeun, Rajaram, Lakshmi, Chu, Yanjie, Carrico, Isaac S

“…The modification of virus particles has received a significant amount of attention for its tremendous potential for impacting gene therapy, oncolytic…”
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Chemoselective modification of viral proteins bearing metabolically introduced "clickable" amino acids and sugars by Banerjee, Partha S, Carrico, Isaac S

“…The inherent difficulty of performing chemical modifications of proteins in a truly site-specific fashion is often compounded by the need to work within…”
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Correction to Compartment-Specific Labeling of Bacterial Periplasmic Proteins by Peroxidase-Mediated Biotinylation by Ganapathy, Uday S, Bai, Lu, Wei, Linpeng, Eckartt, Kathryn A, Lett, Clarissa M, Previti, Mary L, Carrico, Isaac S, Seeliger, Jessica C

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