Effectiveness of Photodynamic Therapy in Elimination of HPV‐16 and HPV‐18 Associated with CIN I in Mexican Women

This study aimed to determine the effectiveness of photodynamic therapy (PDT), using δ‐aminolevulinic acid (5‐ALA), in the elimination of premalignant cervical lesions in Mexican patients with human papillomavirus (HPV) infection and/or cervical intraepithelial neoplasia (CIN). Thirty women diagnose...

Full description

Saved in:

Bibliographic Details
Published in:	Photochemistry and photobiology Vol. 93; no. 5; pp. 1269 - 1275
Main Authors:	Maldonado Alvarado, Elizabeth, Osorio Peralta, Martha Olivia, Moreno Vázquez, Alejandra, Martínez Guzmán, Lydia Alejandra, Melo Petrone, Maria Eugenia, Enriquez Mar, Zulma Iveth, Jovel Galdamez, Dora Estela, Carrión Solana, Bárbara, Balderas Martínez, Guadalupe, Parra, Eduarda, Castellanos Oliveros, Rossana Inés, Bello Leiva, Rosa Linda, Espinosa Montesinos, Araceli, Barrera Mendoza, Citlalli, Medina García, Selma Eugenia, Ramón Gallegos, Eva
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01-10-2017
Subjects:	Adult Aminolevulinic acid Aminolevulinic Acid - pharmacology Aminolevulinic Acid - therapeutic use Cervical Intraepithelial Neoplasia - drug therapy Cervical Intraepithelial Neoplasia - virology Cervix Colposcopy Cytology Female Human papillomavirus Human papillomavirus 16 - drug effects Human papillomavirus 18 - drug effects Humans Infections Lesions Mexico Papillomavirus Infections - drug therapy Papillomavirus Infections - virology Patients Photochemotherapy - adverse effects Photodynamic therapy Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use Polymerase chain reaction Regression analysis Statistical analysis Treatment Outcome Uterus Womens health Mexico
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	This study aimed to determine the effectiveness of photodynamic therapy (PDT), using δ‐aminolevulinic acid (5‐ALA), in the elimination of premalignant cervical lesions in Mexican patients with human papillomavirus (HPV) infection and/or cervical intraepithelial neoplasia (CIN). Thirty women diagnosed with CIN I and/or positive for HPV participated in the study. Topical 6% 5‐ALA in gel form was applied to the uterine cervix; after 4 h, the lesion area was irradiated with a light dose of 200 J cm−2 at 635 nm. This procedure was performed three times at 48‐h intervals. Clinical follow‐up was performed at 3, 6, and 12 months after the initial PDT administration, by colposcopy, cervical cytology, histopathological analysis, polymerase chain reaction, and hybrid capture. Of HPV‐infected patients without evidence of CIN I, 80% cleared the infection, while HPV associated with CIN I was eliminated in 83% of patients (P < 0.05). At 12 months, CIN I had regressed in 57% of patients, although this response was not statistically significant. PDT using 6% 5‐ALA is concluded to be effective in eliminating HPV infection associated or not with CIN I. We investigated the effectiveness of photodynamic therapy using δ‐aminolevulinic acid in eliminating premalignant cervical lesions in patients with HPV infection and/or cervical intraepithelial neoplasia (CIN). Topical 6% 5‐ALA gel was applied to the uterine cervix; 4 h later, the lesion was irradiated with a dose of 200 J cm−2 (635 nm). This procedure was repeated 3× at 48‐h intervals. Clinical follow‐up showed that in HPV‐infected patients without CIN I, 80% cleared the infection, while HPV associated with CIN I was eliminated in 83% of patients (P < 0.05). At 12 months, CIN I had regressed in 57% of patients, although not statistically significantly.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0031-8655 1751-1097
DOI:	10.1111/php.12769