Search Results - "Carriére, Fréderic"

Impact of gastrointestinal lipolysis on oral lipid-based formulations and bioavailability of lipophilic drugs by Carriere, Frederic

“…Oil-in-water emulsions are common vehicles for lipids as nutrients and for the delivery of poorly water-soluble drugs. Enhancing oral bioavailability of these…”
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INFOGEST static in vitro simulation of gastrointestinal food digestion by Brodkorb, André, Egger, Lotti, Alminger, Marie, Alvito, Paula, Assunção, Ricardo, Ballance, Simon, Bohn, Torsten, Bourlieu-Lacanal, Claire, Boutrou, Rachel, Carrière, Frédéric, Clemente, Alfonso, Corredig, Milena, Dupont, Didier, Dufour, Claire, Edwards, Cathrina, Golding, Matt, Karakaya, Sibel, Kirkhus, Bente, Le Feunteun, Steven, Lesmes, Uri, Macierzanka, Adam, Mackie, Alan R., Martins, Carla, Marze, Sébastien, McClements, David Julian, Ménard, Olivia, Minekus, Mans, Portmann, Reto, Santos, Cláudia N., Souchon, Isabelle, Singh, R. Paul, Vegarud, Gerd E., Wickham, Martin S. J., Weitschies, Werner, Recio, Isidra

“…Developing a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the…”
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Relevant pH and lipase for in vitro models of gastric digestion by Sams, Laura, Paume, Julie, Giallo, Jacqueline, Carrière, Frédéric

“…The development of in vitro digestion models relies on the availability of in vivo data such as digestive enzyme levels and pH values recorded in the course of…”
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The endosomal lipid bis(monoacylglycero) phosphate as a potential key player in the mechanism of action of chloroquine against SARS-COV-2 and other enveloped viruses hijacking the endocytic pathway by Carrière, Frédéric, Longhi, Sonia, Record, Michel

“…The anti-malarial drug Chloroquine (CQ) and its derivative hydroxychloroquine have shown antiviral activities in vitro against many viruses, including…”
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Variations in gastrointestinal lipases, pH and bile acid levels with food intake, age and diseases: Possible impact on oral lipid-based drug delivery systems by Amara, Sawsan, Bourlieu, Claire, Humbert, Lydie, Rainteau, Dominique, Carrière, Frédéric

“…The lipids and some surfactants present in oral lipid-based drug delivery systems are potential substrates for the various lipases involved in gastrointestinal…”
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Biogenesis and fate of lipid droplets by Li-Beisson, Yonghua, Carrière, Frédéric

“…Editorial Special issue "Biogenesis and Fate of Lipid Droplets" Intracellular lipid droplets (LDs) are receiving increasing interest from the scientific…”
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Effects of Surfactants on Lipase Structure, Activity, and Inhibition by Delorme, Vincent, Dhouib, Rabeb, Canaan, Stéphane, Fotiadu, Frédéric, Carrière, Frédéric, Cavalier, Jean-François

“…ABSTRACT Lipase inhibitors are the main anti-obesity drugs prescribed these days, but the complexity of their mechanism of action is making it difficult to…”
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Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: method parameterization and comparison of in vitro digestion profiles across a range of representative formulations by Williams, Hywel D, Sassene, Philip, Kleberg, Karen, Bakala-N'Goma, Jean-Claude, Calderone, Marilyn, Jannin, Vincent, Igonin, Annabel, Partheil, Anette, Marchaud, Delphine, Jule, Eduardo, Vertommen, Jan, Maio, Mario, Blundell, Ross, Benameur, Hassan, Carrière, Frédéric, Müllertz, Anette, Porter, Christopher J H, Pouton, Colin W

“…The Lipid Formulation Classification System Consortium is an industry-academia collaboration, established to develop standardized in vitro methods for the…”
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Characterization of all the lipolytic activities in pancreatin and comparison with porcine and human pancreatic juices by Salhi, Amal, Amara, Sawsan, Mansuelle, Pascal, Puppo, Rémy, Lebrun, Régine, Gontero, Brigitte, Aloulou, Ahmed, Carrière, Frédéric

“…Porcine pancreatic extracts (PPE), also named pancreatin, are commonly used as a global source of pancreatic enzymes for enzyme replacement therapy in patients…”
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Orchestration of algal metabolism by protein disorder by Launay, Hélène, Receveur-Bréchot, Véronique, Carrière, Frédéric, Gontero, Brigitte

“…Intrinsically disordered proteins (IDPs) are proteins that provide many functional advantages in a large number of metabolic and signalling pathways. Because…”
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A Metagenomic Investigation of the Duodenal Microbiota Reveals Links with Obesity by Angelakis, Emmanouil, Armougom, Fabrice, Carrière, Frédéric, Bachar, Dipankar, Laugier, René, Lagier, Jean-Christophe, Robert, Catherine, Michelle, Caroline, Henrissat, Bernard, Raoult, Didier

“…Few studies have tested the small intestine microbiota in humans, where most nutrient digestion and absorption occur. Here, our objective was to examine the…”
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Inhibition of CpLIP2 Lipase Hydrolytic Activity by Four Flavonols (Galangin, Kaempferol, Quercetin, Myricetin) Compared to Orlistat and Their Binding Mechanisms Studied by Quenching of Fluorescence by Nasri, Ruba, Bidel, Luc P R, Rugani, Nathalie, Perrier, Véronique, Carrière, Frédéric, Dubreucq, Eric, Jay-Allemand, Christian

“…The inhibition of recombinant CpLIP2 lipase/acyltransferase from was considered a key model for novel antifungal drug discovery and a potential therapeutic…”
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Fatty Acid Photodecarboxylase Is an Interfacial Enzyme That Binds to Lipid–Water Interfaces to Access Its Insoluble Substrate by Aselmeyer, Cyril, Légeret, Bertrand, Bénarouche, Anaïs, Sorigué, Damien, Parsiegla, Goetz, Beisson, Fred, Carrière, Frédéric

“…Fatty acid photodecarboxylase (FAP), one of the few natural photoenzymes characterized so far, is a promising biocatalyst for lipid-to-hydrocarbon conversion…”
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Impact of pasteurization of human milk on preterm newborn in vitro digestion: Gastrointestinal disintegration, lipolysis and proteolysis by de Oliveira, Samira C., Bourlieu, Claire, Ménard, Olivia, Bellanger, Amandine, Henry, Gwénaële, Rousseau, Florence, Dirson, Emelyne, Carrière, Frédéric, Dupont, Didier, Deglaire, Amélie

“…•Set up of a gastrointestinal in vitro dynamic digestion model for preterm newborn.•Holder pasteurization of preterm human milk impacts its…”
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Direct Analysis of Phycobilisomal Antenna Proteins and Metabolites in Small Cyanobacterial Populations by Laser Ablation Electrospray Ionization Mass Spectrometry by Parsiegla, Goetz, Shrestha, Bindesh, Carrière, Frédéric, Vertes, Akos

“…Due to their significance in energy and environmental and natural product research, as well as their large genetic diversity, rapid in situ analysis of…”
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Blocking Gastric Lipase Adsorption and Displacement Processes with Viscoelastic Biopolymer Adsorption Layers by Scheuble, Nathalie, Lussi, Micha, Geue, Thomas, Carrière, Frédéric, Fischer, Peter

“…Delayed fat digestion might help to fight obesity. Fat digestion begins in the stomach by adsorption of gastric lipases to oil/water interfaces. In this study…”
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Interfacial adsorption and activity of pancreatic lipase-related protein 2 onto heterogeneous plant lipid model membranes by Kergomard, Jeanne, Carrière, Frédéric, Paboeuf, Gilles, Chonchon, Lauriane, Barouh, Nathalie, Vié, Véronique, Bourlieu, Claire

“…Pancreatic lipase related-protein 2 (PLRP2) exhibits remarkable galactolipase and phospholipase A1 activities, which depend greatly on the supramolecular…”
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Postprandial bile acid levels in intestine and plasma reveal altered biliary circulation in chronic pancreatitis patients by Humbert, Lydie, Rainteau, Dominique, Tuvignon, Noshine, Wolf, Claude, Seksik, Philippe, Laugier, René, Carrière, Frédéric

“…Bile acid (BA) secretion and circulation in chronic pancreatitis (CP) patients with exocrine pancreatic insufficiency (EPI) were investigated by simultaneously…”
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Lipids in the Stomach – Implications for the Evaluation of Food Effects on Oral Drug Absorption by Koziolek, Mirko, Carrière, Frédéric, Porter, Christopher J. H.

“…Food effects on oral drug bioavailability can have significant impact on the provision of safe and reliable oral pharmacotherapy. A mechanistic understanding…”
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Studies of crab digestive phospholipase acting on phospholipid monolayers: Activation by temperature by Cherif, Slim, Carrière, Frederic, Sayari, Adel, Fendri, Ahmed

“…Secreted phospholipases A2 (sPLA2) are water-soluble lipolytic enzymes that act at the interface of organized lipid substrates, where the catalytic step is…”
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