Search Results - "Carri, M. T."

Oxidative stress and mitochondrial damage in the pathogenesis of ALS: New perspectives by Bozzo, F., Mirra, A., Carrì, M.T.

“…This review attempts to reconcile the present dual view of the mechanisms operating in Amyotrophic Lateral Sclerosis (ALS). On one side, oxidative stress,…”
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Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways by Valle, C, Salvatori, I, Gerbino, V, Rossi, S, Palamiuc, L, René, F, Carrì, M T

“…Acetylation homeostasis is thought to play a role in amyotrophic lateral sclerosis, and treatment with inhibitors of histone deacetylases has been considered a…”
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Pur-alpha functionally interacts with FUS carrying ALS-associated mutations by Di Salvio, M, Piccinni, V, Gerbino, V, Mantoni, F, Camerini, S, Lenzi, J, Rosa, A, Chellini, L, Loreni, F, Carrì, M T, Bozzoni, I, Cozzolino, M, Cestra, G

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder due to motor neuron loss. Fused in sarcoma (FUS) protein carrying ALS-associated…”
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Beta-amyloid causes downregulation of calcineurin in neurons through induction of oxidative stress by Celsi, F, Svedberg, M, Unger, C, Cotman, C.W, Carrì, M.T, Ottersen, O.P, Nordberg, A, Torp, R

“…Abstract Calcineurin is an abundant cytosolic protein that is implicated in the modulation of glutamate release. Here we show that the expression level of this…”
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Apoptosome inactivation rescues proneural and neural cells from neurodegeneration by Cozzolino, M, Ferraro, E, Ferri, A, Rigamonti, D, Quondamatteo, F, Ding, H, Xu, Z S, Ferrari, F, Angelini, D F, Rotilio, G, Cattaneo, E, Carrì, M T, Cecconi, F

“…Deficiency of the apoptosome component Apaf1 leads to accumulation of supernumerary brain cells in mouse embryos. We observed that neural precursor cells…”
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Bcl2a1 serves as a switch in death of motor neurons in amyotrophic lateral sclerosis by Crosio, C, Casciati, A, Iaccarino, C, Rotilio, G, Carrì, M T

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Aberrant Copper Chemistry as a Major Mediator of Oxidative Stress in a Human Cellular Model of Amyotrophic Lateral Sclerosis by Gabbianelli, Roberta, Ferri, Alberto, Rotilio, Giuseppe, Carrì, Maria Teresa

“…: We have investigated the response to oxidative stress in a model system obtained by stable transfection of the human neuroblastoma cell line SH‐SY5Y with…”
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The unfolded protein response in models of human mutant G93A amyotrophic lateral sclerosis by Prell, T., Lautenschläger, J., Witte, O. W., Carri, M. T., Grosskreutz, J.

“…Recent studies indicate that endoplasmic reticulum (ER) stress is involved in the pathogenesis of familial and sporadic amyotrophic lateral sclerosis (ALS). ER…”
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Calcineurin Activity Is Regulated Both by Redox Compounds and by Mutant Familial Amyotrophic Lateral Sclerosis‐Superoxide Dismutase by Ferri, Alberto, Gabbianelli, Roberta, Casciati, Arianna, Paolucci, Egle, Rotilio, Giuseppe, Carrì, Maria Teresa

“…Calcineurin (CN) is a protein phosphatase involved in a wide range of cellular responses to calcium‐mobilizing signals, and a role for this enzyme in…”
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Structural insights into the multi-determinant aggregation of TDP-43 in motor neuron-like cells by Bozzo, F, Salvatori, I, Iacovelli, F, Mirra, A, Rossi, S, Cozzolino, M, Falconi, M, Valle, C, Carrì, M.T

“…Abstract TDP-43 is aggregated in patients with ALS and FLTD through mechanisms still incompletely understood. Since aggregation in the cytosol is most probably…”
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Oxidative inactivation of calcineurin by Cu,Zn superoxide dismutase G93A, a mutant typical of familial amyotrophic lateral sclerosis by Ferri, Alberto, Gabbianelli, Roberta, Casciati, Arianna, Celsi, Fulvio, Rotilio, Giuseppe, Carrì, Maria Teresa

“…Calcineurin is a serine/threonine phosphatase involved in a wide range of cellular responses to calcium mobilizing signals. Previous evidence supports the…”
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Differential role of superoxide and glutathione in S‐nitrosoglutathione‐mediated apoptosis: a rationale for mild forms of familial amyotrophic lateral sclerosis associated with less active Cu,Zn superoxide dismutase mutants by Ciriolo, Maria Rosa, Aquilano, Katia, De Martino, Angelo, Carrì, Maria Teresa, Rotilio, Giuseppe

“…SH‐SY5Y cells transfected with the enzymatically inactive Cu,Zn superoxide dismutase mutant H46R were more resistant to S‐nitrosoglutathione (GSNO)‐induced…”
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Cu,Zn-Superoxide Dismutase-dependent Apoptosis Induced by Nitric Oxide in Neuronal Cells by Ciriolo, Maria Rosa, De Martino, Angelo, Lafavia, Emanuela, Rossi, Luisa, Carrı̀, Maria Teresa, Rotilio, Giuseppe

“…Nitric oxide (NO) challenge to human neuroblastoma cells (SH-SY5Y) ultimately results in apoptosis. Tumor suppressor protein p53 and cell cycle inhibitor p21…”
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Copper-dependent metabolism of Cu,Zn-superoxide dismutase in human K562 cells : lack of specific transcriptional activation and accumulation of a partially inactivated enzyme by STEINKÜHLER, C, CARRI, M. T, MICHELI, G, KNOEPFEL, L, WESER, U, ROTILIO, G

“…The regulation of Cu,Zn-superoxide dismutase by copper was investigated in human K562 cells. Copper ions caused a dose- and time-dependent increase, up to…”
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Increase of Cu,Zn-superoxide dismutase activity during differentiation of human K562 cells involves activation by copper of a constantly expressed copper-deficient protein by Steinkühler, C, Sapora, O, Carrì, M T, Nagel, W, Marcocci, L, Ciriolo, M R, Weser, U, Rotilio, G

“…Cu,Zn-superoxide dismutase activity, expressed on the basis of cell number, increased by 50% during sodium butyrate-induced differentiation of human K562…”
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A study of the dual role of copper in superoxide dismutase as antioxidant and pro-oxidant in cellular models of amyotrophic lateral sclerosis by Carrì, M T, Battistoni, A, Ferri, A, Gabbianelli, R, Rotilio, G

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Voltage-activated sodium currents in a cell line expressing a Cu,Zn superoxide dismutase typical of familial ALS by Zona, Cristina, Ferri, Alberto, Gabbianelli, Roberta, Mercuri, Nicola B, Bernardi, Giorgio, Rotilio, Giuseppe, Carri, Maria Teresa

“…THE whole-cell configuration of the patch-clamp recording was used to study the voltage-dependent Na currents in a model system for the familial form of…”
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Modulation of the Catalytic Rate of Cu,Zn Superoxide Dismutase in Single and Double Mutants of Conserved Positively and Negatively Charged Residues by Polticelli, Fabio, Bottaro, Grazia, Battistoni, Andrea, Carri, Maria Teresa, Djinovic-Carugo, Kristina, Bolognesi, Martino, O'Neill, Peter, Rotilio, Giuseppe, Desideri, Alessandro

“…The catalytic rate of four single and three double mutants of Xenopus laevis Cu,Zn superoxide dismutase B, neutralized at Lys120, Asp130, Glu131, and Lys134,…”
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Evidence for co-regulation of Cu,Zn superoxide dismutase and metallothionein gene expression in yeast through transcriptional control by copper via the ACE 1 factor by Carri, Maria Teresa, Galiazzo, Francesca, Ciriolo, Maria Rosa, Rotilio, Giuseppe

“…Saccharomyces cerevisiae mutant strain DTY26, lacking ACE1, the protein mediator for the induction or metallothionein gene expression, is unable to increase…”
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Crystallisation and preliminary crystallographic analysis of recombinant Xenopus laevis Cu,Zn superoxide dismutase b by Djinovic Carugo, K, Collyer, C, Coda, A, Carrì, M T, Battistoni, A, Bottaro, G, Polticelli, F, Desideri, A, Bolognesi, M

“…The recombinant Cu,Zn superoxide dismutase from the South African frog Xenopus laevis, expressed in E. coli, has been crystallized in a form suitable for high…”
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