Interpenetrated polymer networks of poly(β-cyclodextrin) and polyvinylpyrrolidone with synergistic and selective sorption capacities

[Display omitted] •Sorption in IPNs occur by inclusion within CD cavities and specific interactions.•Synergistic sorption of naphthalenes and additive for tannic acid are found.•Cetirizine and pseudoephedrine, drugs used in combined therapies, can be loaded. Interpenetrating polymer network (IPN) hy...

Full description

Saved in:

Bibliographic Details
Published in:	Carbohydrate polymers Vol. 219; pp. 105 - 112
Main Authors:	Fujiyoshi, Takeo, Carrez, Olivier, Imizcoz, Mikel, Zornoza, Arantza, Isasi, José Ramón
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-09-2019
Subjects:	Cyclodextrin polymers Hydrogels IPN Poly(N-vinylpyrrolidone) Sorption Sorption Cyclodextrin polymers Poly(N-vinylpyrrolidone) Hydrogels IPN
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	[Display omitted] •Sorption in IPNs occur by inclusion within CD cavities and specific interactions.•Synergistic sorption of naphthalenes and additive for tannic acid are found.•Cetirizine and pseudoephedrine, drugs used in combined therapies, can be loaded. Interpenetrating polymer network (IPN) hydrogels were synthesised using β-cyclodextrin (β-CD) and N-vynil-2-pyrrolidone (NVP) crosslinked with epichlorohydrin and divinylbenzene, respectively, and prepared by four different procedures: simultaneous, sequential, hybrid and a novel one named hybrid-sequential. The IPNs prepared have been characterised by infrared spectroscopy and thermal analysis. The equilibrium swelling in water and the sorption of model substances into the IPNs have also been studied. The model sorbates (1-naphthol, 2-acetylnaphthalene and tannic acid) were selected according to the affinities towards each one of the two constituent polymers. Our studies reveal that these IPNs can be applied for the sorption of substances that can interact with the network by two mechanisms, i.e. inclusion within cyclodextrin cavities and/or via specific interactions with the functional groups present. Besides, due to the complementary character of their constituent polymers, these networks could also serve to retain two substances of different nature such as cetirizine and pseudoephedrine.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0144-8617 1879-1344
DOI:	10.1016/j.carbpol.2019.05.027