Search Results - "Carrasco, Rosa A."

Antitumor activity of AZD0754, a dnTGFβRII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer by Zanvit, Peter, van Dyk, Dewald, Fazenbaker, Christine, McGlinchey, Kelly, Luo, Weichuan, Pezold, Jessica M, Meekin, John, Chang, Chien-Ying, Carrasco, Rosa A, Breen, Shannon, Cheung, Crystal Sao-Fong, Endlich-Frazier, Ariel, Clark, Benjamin, Chu, Nina J, Vantellini, Alessio, Martin, Philip L, Hoover, Clare E, Riley, Kenesha, Sweet, Steve M, Chain, David, Kim, Yeoun Jin, Tu, Eric, Harder, Nathalie, Phipps, Sandrina, Damschroder, Melissa, Gilbreth, Ryan N, Cobbold, Mark, Moody, Gordon, Bosco, Emily E

“…Prostate cancer is generally considered an immunologically "cold" tumor type that is insensitive to immunotherapy. Targeting surface antigens on tumors through…”
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Antisense inhibition of survivin expression as a cancer therapeutic by Carrasco, Rosa A, Stamm, Nancy B, Marcusson, Eric, Sandusky, George, Iversen, Philip, Patel, Bharvin K R

“…Survivin, a family member of the inhibitor of apoptosis proteins that is expressed during mitosis in a cell cycle-dependent manner and localized to different…”
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A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors by Zhong, Haihong, Davis, April, Ouzounova, Maria, Carrasco, Rosa A, Chen, Cui, Breen, Shannon, Chang, Yong S, Huang, Jiaqi, Liu, Zheng, Yao, Yihong, Hurt, Elaine, Moisan, Jacques, Fung, Michael, Tice, David A, Clouthier, Shawn G, Xiao, Zhan, Wicha, Max S, Korkaya, Hasan, Hollingsworth, Robert E

“…Elevated levels of the proinflammatory cytokine IL6 are associated with poor survival outcomes in many cancers. Antibodies targeting IL6 and its receptor have…”
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One-step cellular caspase-3/7 assay by Carrasco, Rosa A, Stamm, Nancy B, Patel, Bharvin K R

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A Potent HER3 Monoclonal Antibody That Blocks Both Ligand-Dependent and -Independent Activities: Differential Impacts of PTEN Status on Tumor Response by Xiao, Zhan, Carrasco, Rosa A, Schifferli, Kevin, Kinneer, Krista, Tammali, Ravinder, Chen, Hong, Rothstein, Ray, Wetzel, Leslie, Yang, Chunning, Chowdhury, Partha, Tsui, Ping, Steiner, Philipp, Jallal, Bahija, Herbst, Ronald, Hollingsworth, Robert E, Tice, David A

“…HER3/ERBB3 is a kinase-deficient member of the EGFR family receptor tyrosine kinases (RTK) that is broadly expressed and activated in human cancers. HER3 is a…”
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The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of MyoD by Lemercier, Claudie, To, Robert Q., Carrasco, Rosa A., Konieczny, Stephen F.

“…A good model system to examine aspects of positive and negative transcriptional regulation is the muscle‐specific regulatory factor, MyoD, which is a basic…”
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Preclinical Evaluation of AZD6422, an Armored Chimeric Antigen Receptor T Cell Targeting CLDN18.2 in Gastric, Pancreatic, and Esophageal Cancers by Barrett, Allison M., Britton, Zachary T., Carrasco, Rosa A., Breen, Shannon, Broggi, Maria A.S., Hatke, Amanda L., Clark, Benjamin, Yang, Chunning, Phipps, Sandrina, Ortiz, Lorenzo, Janocha, Brianna, Zanvit, Peter, Giraldo, Nicolas A., Martin, Philip L., Lapointe, Jean-Martin, Harder, Nathalie, Cornish, Georgina H., Attili, Bala N.N.R., Mazor, Yariv, Damschroder, Melissa, Cobbold, Mark, Moody, Gordon, Bosco, Emily E.

“…Abstract Purpose: Claudin 18.2 (CLDN18.2) is a surface membrane protein that is crucial for maintaining tight junctions in gastric mucosal cells and is highly…”
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Role of exogenous inositol and phosphatidylinositol in glycosylphosphatidylinositol anchor synthesis of GP49 by Giardia lamblia by Subramanian, Anna B, Navarro, Solangel, Carrasco, Rosa A, Marti, Matthias, Das, Siddhartha

“…Although Giardia lamblia trophozoites are unable to carry out de novo phospholipid synthesis, they can assemble complex glycophospholipids from simple lipids…”
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Antitumor activity of AZD0754, a dnTGF[beta]RII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer by Zanvit, Peter, van Dyk, Dewald, Fazenbaker, Christine, McGlinchey, Kelly, Luo, Weichuan, Pezold, Jessica M, Meekin, John, Chang, Chien-ying, Carrasco, Rosa A, Breen, Shannon, Cheung, Crystal Sao-Fong, Endlich-Frazier, Ariel, Clark, Benjamin, Chu, Nina J, Vantellini, Alessio, Martin, Philip L, Hoover, Clare E, Riley, Kenesha, Sweet, Steve M, Chain, David, Kim, Yeoun Jin, Tu, Eric, Harder, Nathalie, Phipps, Sandrina, Damschroder, Melissa, Gilbreth, Ryan N, Cobbold, Mark, Moody, Gordon, Bosco, Emily E

“…Prostate cancer is generally considered an immunologically "cold" tumor type that is insensitive to immunotherapy. Targeting surface antigens on tumors through…”
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EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner: Implications for EphB4 as a cancer target by Xiao, Zhan, Carrasco, Rosa, Kinneer, Krista, Sabol, Darrin, Jallal, Bahija, Coats, Steve, Tice, David A.

“…EphB4 is a member of the Eph receptor tyrosine kinase family shown to act in neuronal guidance and mediate venal/arterial separation. In contrast to these more…”
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Abstract 2272: Understanding resistance to Trail and Trail agonists by Chen, Hong, Carrasco, Rosa A., Feng, Hui, Hollingsworth, Robert E., Xiao, Zhan, Tice, David A.

“…Abstract Trail and Trail agonists induce apoptotic cell death in cancer cells while sparing normal cells making them promising drug candidates. However, Trail…”
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Preclinical Evaluation of AZD6422, an Armored Chimeric Antigen Receptor T Cell Targeting CLDN18.2 in Gastric, Pancreatic, and Esophageal Cancer by Barrett, Allison M, Britton, Zachary T, Carrasco, Rosa A, Breen, Shannon, Broggi, Maria A S, Hatke, Amy, Clark, Benjamin, Yang, Chunning, Phipps, Sandrina, Ortiz, Lorenzo, Janocha, Brianna, Zanvit, Peter, Giraldo, Nicolas A, Martin, Philip L, Lapointe, Jean-Martin, Harder, Nathalie, Cornish, Georgina H, Attili, Bala N N R, Mazor, Yariv, Damschroder, Melissa, Cobbold, Mark, Moody, Gordon, Bosco, Emily E

“…CLDN18.2 is a surface membrane protein crucial for maintaining tight junctions in gastric mucosal cells and is highly expressed in gastric, esophageal, and…”
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Abstract 558: MEDI3379, a human monoclonal antibody against HER3, suppresses HER3 activity and cell proliferation in both ligand-dependent and independent cancers by Rosa, Carrasco A., Wetzel, Leslie, Kinner, Krista, Chen, Hong, Rothstein, Raymond, Tice, David, Hollingsworth, Robert, Steiner, Philipp, Xiao, Zhan

“…Abstract HER3 (ErbB3) is a member of the EGFR/HER family of receptor tyrosine kinases (RTK), consisting of EGFR, HER2, HER3 and HER4. Due to its unique…”
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Abstract 239: A novel multimeric protein scaffold stimulates apoptotic signaling through TRAILR2 by Chen, Hong, Swers, Jeffery, Inigo, Ivan, Carrasco, Rosa A., Grinberg, Luba, Wang, Lin, Leow, Ching-Ching, Xiao, Zhan, Wu, Herren, Hollingsworth, Bob, Baca, Manuel, Tice, David A.

“…Abstract TRAILR2 (DR5, TNFRSF10B) is a member of the TNF-receptor superfamily that mediates programmed cell death following stimulation with its ligand…”
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Abstract 307: EphB4 promotes or suppresses Ras/ERK pathway depending on cellular contexts: Implications for EphB4 as a cancer target by Xiao, Zhan, Carrasco, Rosa A., Kinneer, Krista, Sabol, Darrin, Coats, Steve, Jallal, Bahija, Tice, David

“…Abstract EphB4 is a member of the Eph RTK family. Its classical role has been shown to act in neuronal guidance and mediate venal/arterial separation. In…”
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