Search Results - "Carrasco, César"

Optogenetic control of the lac operon for bacterial chemical and protein production by Lalwani, Makoto A., Ip, Samantha S., Carrasco-López, César, Day, Catherine, Zhao, Evan M., Kawabe, Hinako, Avalos, José L.

“…Control of the lac operon with isopropyl β- d -1-thiogalactopyranoside (IPTG) has been used to regulate gene expression in Escherichia coli for countless…”
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Optogenetic control of protein binding using light-switchable nanobodies by Gil, Agnieszka A., Carrasco-López, César, Zhu, Liyuan, Zhao, Evan M., Ravindran, Pavithran T., Wilson, Maxwell Z., Goglia, Alexander G., Avalos, José L., Toettcher, Jared E.

“…A growing number of optogenetic tools have been developed to reversibly control binding between two engineered protein domains. In contrast, relatively few…”
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Biosensor for branched-chain amino acid metabolism in yeast and applications in isobutanol and isopentanol production by Zhang, Yanfei, Cortez, Jeremy D., Hammer, Sarah K., Carrasco-López, César, García Echauri, Sergio Á., Wiggins, Jessica B., Wang, Wei, Avalos, José L.

“…Branched-chain amino acid (BCAA) metabolism fulfills numerous physiological roles and can be harnessed to produce valuable chemicals. However, the lack of…”
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Development of light-responsive protein binding in the monobody non-immunoglobulin scaffold by Carrasco-López, César, Zhao, Evan M., Gil, Agnieszka A., Alam, Nathan, Toettcher, Jared E., Avalos, José L.

“…Monobodies are synthetic non-immunoglobulin customizable protein binders invaluable to basic and applied research, and of considerable potential as future…”
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Spectrochemistry of Firefly Bioluminescence by Al-Handawi, Marieh B., Polavaram, Srujana, Kurlevskaya, Anastasiya, Commins, Patrick, Schramm, Stefan, Carrasco-López, César, Lui, Nathan M., Solntsev, Kyril M., Laptenok, Sergey P., Navizet, Isabelle, Naumov, Panče

“…The chemical reactions underlying the emission of light in fireflies and other bioluminescent beetles are some of the most thoroughly studied processes by…”
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Lights up on organelles: Optogenetic tools to control subcellular structure and organization by Kichuk, Therese C., Carrasco‐López, César, Avalos, José L.

“…Since the neurobiological inception of optogenetics, light‐controlled molecular perturbations have been applied in many scientific disciplines to both…”
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Structural basis for the broad specificity of a new family of amino-acid racemases by Espaillat, Akbar, Carrasco-López, César, Bernardo-García, Noelia, Pietrosemoli, Natalia, Otero, Lisandro H., Álvarez, Laura, de Pedro, Miguel A., Pazos, Florencio, Davis, Brigid M., Waldor, Matthew K., Hermoso, Juan A., Cava, Felipe

“…Broad‐spectrum amino‐acid racemases (Bsrs) enable bacteria to generate noncanonical D‐amino acids, the roles of which in microbial physiology, including the…”
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Methodology for 3D Management of University Faculties Using Integrated GIS and BIM Models: A Case Study by Carrasco, César A., Lombillo, Ignacio, Sánchez-Espeso, Javier M., Blanco, Haydee, Boffill, Yosbel

“…Three-dimensional virtual modeling is one of the tools being rapidly implemented in the construction industry, leading to the need for strategies based on…”
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Activation of Bacterial Thermoalkalophilic Lipases Is Spurred by Dramatic Structural Rearrangements by Carrasco-López, César, Godoy, César, de las Rivas, Blanca, Fernández-Lorente, Gloria, Palomo, José M., Guisán, José M., Fernández-Lafuente, Roberto, Martínez-Ripoll, Martín, Hermoso, Juan A.

“…The bacterial thermoalkalophilic lipases that hydrolyze saturated fatty acids at 60–75 °C and pH 8–10 are grouped as the lipase family I.5. We report here the…”
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Disulfide Engineered Lipase to Enhance the Catalytic Activity: A Structure-Based Approach on BTL2 by Godoy, César A, Klett, Javier, Di Geronimo, Bruno, Hermoso, Juan A, Guisán, José M, Carrasco-López, César

“…Enhancement, control, and tuning of hydrolytic activity and specificity of lipases are major goals for the industry. Thermoalkaliphilic lipases from the I.5…”
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The elusive relationship between structure and colour emission in beetle luciferases by Carrasco-López, César, Lui, Nathan M., Schramm, Stefan, Naumov, Panče

“…In beetles, luciferase enzymes catalyse the conversion of chemical energy into light through bioluminescence. The principles of this process have become a…”
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Cell-Wall Remodeling by the Zinc-Protease AmpDh3 from Pseudomonas aeruginosa by Lee, Mijoon, Artola-Recolons, Cecilia, Carrasco-López, César, Martínez-Caballero, Siseth, Hesek, Dusan, Spink, Edward, Lastochkin, Elena, Zhang, Weilie, Hellman, Lance M, Boggess, Bill, Hermoso, Juan A, Mobashery, Shahriar

“…Bacterial cell wall is a polymer of considerable complexity that is in constant equilibrium between synthesis and recycling. AmpDh3 is a periplasmic zinc…”
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Reaction Products and the X‑ray Structure of AmpDh2, a Virulence Determinant of Pseudomonas aeruginosa by Martínez-Caballero, Siseth, Lee, Mijoon, Artola-Recolons, Cecilia, Carrasco-López, César, Hesek, Dusan, Spink, Edward, Lastochkin, Elena, Zhang, Weilie, Hellman, Lance M, Boggess, Bill, Mobashery, Shahriar, Hermoso, Juan A

“…The zinc protease AmpDh2 is a virulence determinant of Pseudomonas aeruginosa, a problematic human pathogen. The mechanism of how the protease manifests…”
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Determination of glycosidase activity in porcine oviductal fluid at the different phases of the estrous cycle by Carrasco, Luis César, Romar, Raquel, Avilés, Manuel, Gadea, Joaquín, Coy, Pilar

“…Sperm–oocyte binding and gamete–oviductal epithelium interactions are carbohydrate-mediated events occurring in the oviductal fluid (OF). Thus, knowledge about…”
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High-Resolution Crystal Structure of MltE, an Outer Membrane-Anchored Endolytic Peptidoglycan Lytic Transglycosylase from Escherichia coli by Artola-Recolons, Cecilia, Carrasco-López, César, Llarrull, Leticia I, Kumarasiri, Malika, Lastochkin, Elena, Martínez de Ilarduya, Iñaki, Meindl, Kathrin, Usón, Isabel, Mobashery, Shahriar, Hermoso, Juan A

“…The crystal structure of the first endolytic peptidoglycan lytic transglycosylase MltE from Escherichia coli is reported here. The degradative activity of this…”
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Mechanical properties and microstructural stability of CuTa/Cu composite coatings by Bahrami, Amin, Onofre Carrasco, Cesar F., Cardona, Arturo Delgado, Huminiuc, Teodor, Polcar, Tomas, Rodil, Sandra E.

“…In this study, the structure and mechanical properties of as-deposited and 823.15 K annealed CuTa coatings were studied with the purpose to evaluate the…”
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Optogenetics and biosensors set the stage for metabolic cybergenetics by Carrasco-López, César, García-Echauri, Sergio A, Kichuk, Therese, Avalos, José L

“…[Display omitted] •Metabolic cybergenetics promises unprecedented real-time control of fermentations.•Optogenetic regulators make ideal actuators for metabolic…”
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How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function by Otero, Lisandro H., Rojas-Altuve, Alzoray, Llarrull, Leticia I., Carrasco-López, Cesar, Kumarasiri, Malika, Lastochkin, Elena, Fishovitz, Jennifer, Dawley, Matthew, Hesek, Dusan, Lee, Mijoon, Johnson, Jarrod W., Fisher, Jed F., Chang, Mayland, Mobashery, Shahriar, Hermoso, Juan A.

“…The expression of penicillin binding protein 2a (PBP2a) is the basis for the broad clinical resistance to the β-lactam antibiotics by methicillin-resistant…”
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The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation by Nawaz, Mir Hussain, Ferreira, Juliana C, Nedyalkova, Lyudmila, Zhu, Haizhong, Carrasco-López, César, Kirmizialtin, Serdal, Rabeh, Wael M

“…The high proliferation rate of tumor cells demands high energy and metabolites that are sustained by a high glycolytic flux known as the 'Warburg effect'. The…”
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Quantitative and Qualitative Analysis on the Integration of Geographic Information Systems and Building Information Modeling for the Generation and Management of 3D Models by Carrasco, César A., Lombillo, Ignacio, Sánchez-Espeso, Javier M., Balbás, Francisco Javier

“…3D virtual management is a topic of growing interest. The AEC industry is undergoing a real revolution because of the technological changes that are taking…”
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