Search Results - "Carrara, C."

TriTECM: A tetrafunctional T-cell engaging antibody with built-in risk mitigation of cytokine release syndrome by Carrara, Stefania C., Harwardt, Julia, Grzeschik, Julius, Hock, Björn, Kolmar, Harald

“…Harnessing the innate power of T cells for therapeutic benefit has seen many shortcomings due to cytotoxicity in the past, but still remains a very attractive…”
Get full text

Design of a Trispecific Checkpoint Inhibitor and Natural Killer Cell Engager Based on a 2 + 1 Common Light Chain Antibody Architecture by Bogen, Jan P, Carrara, Stefania C, Fiebig, David, Grzeschik, Julius, Hock, Björn, Kolmar, Harald

“…Natural killer cell engagers gained enormous interest in recent years due to their potent anti-tumor activity and favorable safety profile. Simultaneously,…”
Get full text

Targeted Phagocytosis Induction for Cancer Immunotherapy via Bispecific MerTK-Engaging Antibodies by Carrara, Stefania C, Bogen, Jan P, Fiebig, David, Grzeschik, Julius, Hock, Björn, Kolmar, Harald

“…The Tyro, Axl, and MerTK receptors (TAMRs) play a significant role in the clearance of apoptotic cells. In this work, the spotlight was set on MerTK, as it is…”
Get full text

Expeditious Generation of Biparatopic Common Light Chain Antibodies via Chicken Immunization and Yeast Display Screening by Bogen, Jan P, Carrara, Stefania C, Fiebig, David, Grzeschik, Julius, Hock, Björn, Kolmar, Harald

“…Bispecific (BsAb) and biparatopic (BpAb) antibodies emerged as promising formats for therapeutic biologics exhibiting tailor-made functional properties. Over…”
Get full text

Generation of a symmetrical trispecific NK cell engager based on a two-in-one antibody by Harwardt, Julia, Carrara, Stefania C, Bogen, Jan P, Schoenfeld, Katrin, Grzeschik, Julius, Hock, Björn, Kolmar, Harald

“…To construct a trispecific IgG-like antibody at least three different binding moieties need to be combined, which results in a complex architecture and…”
Get full text

Parahydrogen-induced polarization allows 2000-fold signal enhancement in biologically active derivatives of the peptide-based drug octreotide by Lins, Jonas, Miloslavina, Yuliya A., Carrara, Stefania C., Rösler, Lorenz, Hofmann, Sarah, Herr, Kevin, Theiß, Franziska, Wienands, Laura, Avrutina, Olga, Kolmar, Harald, Buntkowsky, Gerd

“…Octreotide, a somatostatin analogue, has shown its efficacy for the diagnostics and treatment of various types of cancer, i.e., in octreotide scan, as…”
Get full text

A Generic Strategy to Generate Bifunctional Two-in-One Antibodies by Chicken Immunization by Harwardt, Julia, Bogen, Jan P, Carrara, Stefania C, Ulitzka, Michael, Grzeschik, Julius, Hock, Björn, Kolmar, Harald

“…Various formats of bispecific antibodies exist, among them Two-in-One antibodies in which each Fab arm can bind to two different antigens. Their IgG-like…”
Get full text

Milking the Cow: Cattle-Derived Chimeric Ultralong CDR-H3 Antibodies and Their Engineered CDR-H3-Only Knobbody Counterparts Targeting Epidermal Growth Factor Receptor Elicit Potent NK Cell-Mediated Cytotoxicity by Pekar, Lukas, Klewinghaus, Daniel, Arras, Paul, Carrara, Stefania C, Harwardt, Julia, Krah, Simon, Yanakieva, Desislava, Toleikis, Lars, Smider, Vaughn V, Kolmar, Harald, Zielonka, Stefan

“…In this work, we have generated epidermal growth factor receptor (EGFR)-specific cattle-derived ultralong CDR-H3 antibodies by combining cattle immunization…”
Get full text

Sleep spindle and slow wave activity in Bipolar Disorder: preliminary observations from a high–density EEG study by Sanguineti, C., Donati, F. L., Sala, M., Carrara, C., Casetta, C., Zangani, C., Mayeli, A., Castelnovo, A., Canevini, M. P., D’Agostino, A.

“…Introduction Recent research on Schizophrenia (SCZ) suggests that reduced sleep spindle and slow wave density could be particularly informative of underlying…”
Get full text

Across-surface distances after one- and two-stage palatoplasty in children with oral cleft by Ambrosio, E C P, Bergamo, M T O P, Sforza, C, Carrara, C F C, Machado, M A A M, Oliveira, T M

“…The goal of this study was to digitally evaluate the development of maxillary dental arches of children with unilateral cleft lip and palate treated with one-…”
Get full text

Recombinant Antibody Production Using a Dual-Promoter Single Plasmid System by Carrara, Stefania C., Fiebig, David, Bogen, Jan P., Grzeschik, Julius, Hock, Björn, Kolmar, Harald

“…Monoclonal antibodies (mAbs) have demonstrated tremendous effects on the treatment of various disease indications and remain the fastest growing class of…”
Get full text

3D topographies promote macrophage M2d-Subset differentiation by Carrara, Stefania C., Davila-Lezama, Amanda, Cabriel, Clément, Berenschot, Erwin J.W., Krol, Silke, Gardeniers, J.G.E., Izeddin, Ignacio, Kolmar, Harald, Susarrey-Arce, Arturo

“…In vitro cellular models denote a crucial part of drug discovery programs as they aid in identifying successful drug candidates based on their initial efficacy…”
Get full text

Streamlining the Transition From Yeast Surface Display of Antibody Fragment Immune Libraries to the Production as IgG Format in Mammalian Cells by Fiebig, David, Bogen, Jan P, Carrara, Stefania C, Deweid, Lukas, Zielonka, Stefan, Grzeschik, Julius, Hock, Björn, Kolmar, Harald

“…Yeast-surface display (YSD) is commonly applied to screen Fab immune or naïve libraries for binders of predefined target molecules. However, reformatting of…”
Get full text

Production of ultrapure hydrogen in a Pd-Ag membrane reactor using Ru/La2O3 catalysts by FAROLDI, B, CARRARA, C, LOMBARDO, E. A, COMAGLIA, L. M

Get full text

Induction chemotherapy plus chemoradiotherapy with or without aspirin in high risk rectal cancer (ICAR) by Souza, J.C.E.S.O.D., Araujo, R., Valadão, M., Carrara, C., Barbosa, M.Á, Guimarães, R., Carvalho, J., Kovaleski, G., Small, I., Marins, A., Victorino, A.P., Gil, R., Jesus, J.P., de Araujo, L.H., de Melo, A.C.

Get full text

Mimicking the immunosuppressive impact of fibroblasts in a 3D multicellular spheroid model by Grotz, Melanie, van Gijzel, Lieke, Bitsch, Peter, Carrara, Stefania C., Kolmar, Harald, Garg, Sakshi

“…Targeting the tumor microenvironment (TME) is an attractive strategy for cancer therapy, as tumor cells in vivo are surrounded by many different influential…”
Get full text

Combined oxidation and reforming of methane to produce pure H2 in a membrane reactor by MUNERA, J. F, CARRARA, C, CORNAGLIA, L. M, LOMBARDO, E. A

Get full text

From cell line development to the formulated drug product: The art of manufacturing therapeutic monoclonal antibodies by Carrara, Stefania C., Ulitzka, Michael, Grzeschik, Julius, Kornmann, Henri, Hock, Björn, Kolmar, Harald

“…Created with Biorender.com. [Display omitted] Therapeutic monoclonal antibodies and related products have steadily grown to become the dominant product class…”
Get full text

A stable, novel catalyst improves hydrogen production in a membrane reactor by Irusta, S., Múnera, J., Carrara, C., Lombardo, E.A., Cornaglia, L.M.

“…The dry reforming of methane as a source of H 2 was performed using a well-known catalyst, Rh/La 2O 3, together with a novel one, Rh/La 2O 3-SiO 2, in a…”
Get full text

Preschool Pain Management Program for Young Children with Sickle Cell Disease: A Pre–Post Feasibility Study by Johnston, Julia D, Schatz, Jeffrey, Bills, Sarah E, Frye, Bridgett G, Carrara, Gabriela C

“…Abstract Objective Vaso-occlusive pain crises in sickle cell disease (SCD) often begin in early childhood. We developed an online pain management intervention…”
Get full text