Search Results - "Carr, R D"

Remote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop by Bell, R. M., Basalay, M., Bøtker, H. E., Beikoghli Kalkhoran, S., Carr, R. D., Cunningham, J., Davidson, S. M., England, T. J., Giesz, S., Ghosh, A. K., Golforoush, P., Gourine, A. V., Hausenloy, D. J., Heusch, G., Ibanez, B., Kleinbongard, P., Lecour, S., Lukhna, K., Ntsekhe, M., Ovize, M., Salama, A. D., Vilahur, G., Walker, J. M., Yellon, D. M.

“…The Hatter Cardiovascular Institute biennial workshop, originally scheduled for April 2020 but postponed for 2 years due to the Covid pandemic, was organised…”
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9th Hatter Biannual Meeting: position document on ischaemia/reperfusion injury, conditioning and the ten commandments of cardioprotection by Bell, R. M., Bøtker, H. E., Carr, R. D., Davidson, S. M., Downey, J. M., Dutka, D. P., Heusch, G., Ibanez, B., Macallister, R., Stoppe, C., Ovize, M., Redington, A., Walker, J. M., Yellon, D. M.

“…In the 30 years since the original description of ischaemic preconditioning, understanding of the pathophysiology of ischaemia/reperfusion injury and concepts…”
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Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig by PLAMBOECK, A, HOIST, J. J, CARR, R. D, DEACON, C. F

“…The incretin hormone glucagon-like peptide 1 (GLP-1) has antihyperglycaemic effects, but its therapeutic usefulness is limited by its metabolic instability…”
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GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice by Jolivalt, C. G., Fineman, M., Deacon, C. F., Carr, R. D., Calcutt, N. A.

“…Aim: Glucagon‐like peptide‐1 (GLP‐1) is an incretin hormone that induces glucose‐dependent insulin secretion and may have neurotrophic properties. Our aim was…”
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Glucose-lowering effect of the DPP-4 inhibitor sitagliptin after glucose and non-glucose macronutrient ingestion in non-diabetic subjects by Ohlsson, L., Alsalim, W., Carr, R. D., Tura, A., Pacini, G., Mari, A., Ahrén, B.

“…Aim Recent studies suggest that the incretin concept is not restricted to glucose ingestion but relevant also after non‐glucose macronutrient administration…”
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Inhibitors of dipeptidyl peptidase‐4 as therapeutic agents for individuals with type 2 diabetes: a 25‐year journey by Carr, R. D., Solomon, A.

“…In the 25 years since the hypothesis was first described, therapeutic use of inhibitors of dipeptidyl peptidase‐4 (DPP‐4i) as a novel approach to the treatment…”
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Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes by FUHLENDORFF, J, RORSMAN, P, KOFOD, H, BRAND, C. L, ROLIN, B, MACKAY, P, SHYMKO, R, CARR, R. D

“…Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes. J Fuhlendorff , P Rorsman , H Kofod , C L Brand ,…”
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Drug development from the bench to the pharmacy: with special reference to dipeptidyl peptidase-4 inhibitor development by Carr, R. D.

“…The dipeptidyl peptidase‐4 (DPP‐4) inhibitor concept is an example of prospective drug design and development based upon a distinct endocrine hypothesis. The…”
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Dissociated incretin hormone response to protein versus fat ingestion in obese subjects by Lindgren, O., Carr, R. D., Holst, J. J., Deacon, C. F., Ahrén, B.

“…Protein elicits a stronger early (30 min) glucose‐dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no…”
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Discovery and Structure−Activity Relationship of the First Non-Peptide Competitive Human Glucagon Receptor Antagonists by Madsen, Peter, Knudsen, Lotte B, Wiberg, Finn C, Carr, Richard D

“…The first non-peptide competitive human glucagon receptor antagonist, 2-(benzimidazol-2-ylthio)-1-(3,4-dihydroxyphenyl)-1-ethanone, NNC 92-1687 (2), is…”
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Reduction of beta cell mass: partial insulin secretory compensation from the residual beta cell population in the nicotinamide-streptozotocin Göttingen minipig after oral glucose in vivo and in the perfused pancreas by LARSEN, M. O, ROLIN, B, GOTFREDSEN, C. F, CARR, R. D, HOLST, J. J

“…A progressive loss of beta cell function and mass are important contributory factors in the development and progression of type 2 diabetes. The aim of this…”
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Beta-cell function and islet morphology in normal, obese, and obese beta-cell mass-reduced Göttingen minipigs by Larsen, M O, Juhl, C B, Pørksen, N, Gotfredsen, C F, Carr, R D, Ribel, U, Wilken, M, Rolin, B

“…Herein, we bridge beta-cell function and morphology in minipigs. We hypothesized that different aspects of beta-cell dysfunction are present in obesity and…”
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Loss of beta-cell mass leads to a reduction of pulse mass with normal periodicity, regularity and entrainment of pulsatile insulin secretion in Göttingen minipigs by LARSEN, M. O, GOTFREDSEN, C. F, WILKEN, M, CARR, R. D, PØRKSEN, N, ROLIN, B

“…Type 2 diabetes is associated with impaired insulin action and secretion, including disturbed pulsatile release. Impaired pulsatility has been related to…”
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Sensory nerve inactivation by resiniferatoxin improves insulin sensitivity in male obese Zucker rats by Moesgaard, Sophia G, Brand, Christian L, Sturis, Jeppe, Ahrén, Bo, Wilken, Michael, Fleckner, Jan, Carr, Richard D, Svendsen, Ove, Hansen, Anker J, Gram, Dorte X

“…Recent studies have suggested that sensory nerves may influence insulin secretion and action. The present study investigated the effects of resiniferatoxin…”
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What Lifecycle Management Lessons Can We Learn From Pd-1 Immuno-Oncology Therapies? by Carr, DR, Anastasaki, E, Chriv, E, Bradshaw, SE

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Price Fluctuations Across Lifecycle: Insights From The Anti-Vegf Market by Chriv, E, Carr, DR, Anastasaki, E, Bradshaw, SE

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The conscious Göttingen minipig as a model for studying rapid pulsatile insulin secretion in vivo by LARSEN, M. O, ELANDER, M, STURS, J, WILKEN, M, CARR, R. D, ROLIN, B, PØRKSEN, N

“…Pulsatile secretion is important for insulin action and suitable animal models are important tools for examining the role of impaired pulsatile insulin…”
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Angiotensin(1-7) is an antagonist at the type 1 angiotensin II receptor by Mahon, J M, Carr, R D, Nicol, A K, Henderson, I W

“…The present study investigated the antagonism of the amino-terminal heptapeptide fragment of angiotensin II ([des-Phe8]-angiotensin II; Ang(1-7)) to…”
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Reply to: Ahren B et al. Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans. Diabetes Obes Metab 2011; 13(9): 775-783 and Ahren B et al. Clinical evidence and mechanistic basis for vildagliptin's action when added to metformin. Diabetes Obes Metab 2011; 13(3): 193-203 by Carr, R. D., Katzeff, H. L., Alexander, C. M., Berger, J. P., Xu, S. S., Thornberry, N.

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Parameters of Glucose and Lipid Metabolism in the Male Göttingen Minipig: Influence of Age, Body Weight, and Breeding Family by Larsen, Marianne Olholm, Rolin, Bidda, Wilken, Michael, Carr, Richard David, Svendsen, Ove, Bollen, Peter

“…The pig is useful as a model for human physiology and pathophysiology and could be an important supplement to the many available rodent models of diabetes…”
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