Search Results - "Carr, Kelley"

Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation by Chen, Yi Fan, Ghazala, Maryam, Friedrich, Ryan M., Cordova, Brittany A., Petroze, Frederick N., Srinivasan, Ramya, Allan, Kevin C., Yan, David F., Sax, Joel L., Carr, Kelley, Tomchuck, Suzanne L., Fedorov, Yuriy, Huang, Alex Y., Desai, Amar B., Adams, Drew J.

“…Exportin-1 (XPO1/CRM1) plays a central role in the nuclear-to-cytoplasmic transport of hundreds of proteins and contributes to other cellular processes, such…”
Get full text

Connecting Rodent and Human Pharmacokinetic Models for the Design and Translation of Glucose-Responsive Insulin by Yang, Jing Fan, Gong, Xun, Bakh, Naveed A, Carr, Kelley, Phillips, Nelson F B, Ismail-Beigi, Faramarz, Weiss, Michael A, Strano, Michael S

“…Despite considerable progress, development of glucose-responsive insulins (GRIs) still largely depends on empirical knowledge and tedious…”
Get full text

An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein by Glidden, Michael D., Aldabbagh, Khadijah, Phillips, Nelson B., Carr, Kelley, Chen, Yen-Shan, Whittaker, Jonathan, Phillips, Manijeh, Wickramasinghe, Nalinda P., Rege, Nischay, Swain, Mamuni, Peng, Yi, Yang, Yanwu, Lawrence, Michael C., Yee, Vivien C., Ismail-Beigi, Faramarz, Weiss, Michael A.

“…Thermal degradation of insulin complicates its delivery and use. Previous efforts to engineer ultra-stable analogs were confounded by prolonged cellular…”
Get full text

Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding by Glidden, Michael D., Yang, Yanwu, Smith, Nicholas A., Phillips, Nelson B., Carr, Kelley, Wickramasinghe, Nalinda P., Ismail-Beigi, Faramarz, Lawrence, Michael C., Smith, Brian J., Weiss, Michael A.

“…Domain-minimized insulin receptors (IRs) have enabled crystallographic analysis of insulin-bound “micro-receptors.” In such structures, the C-terminal segment…”
Get full text