Search Results - "Carr, Gregory V."

The role of serotonin receptor subtypes in treating depression: a review of animal studies by Carr, Gregory V., Lucki, Irwin

“…Rationale Serotonin reuptake inhibitors (SSRIs) are effective in treating depression. Given the existence of different families and subtypes of 5-HT receptors,…”
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Ngfr+ cholinergic projection from SI/nBM to mPFC selectively regulates temporal order recognition memory by Mei, Fan, Zhao, Chen, Li, Shangjin, Xue, Zeping, Zhao, Yueyang, Xu, Yihua, Ye, Rongrong, You, He, Yu, Peng, Han, Xinyu, Carr, Gregory V., Weinberger, Daniel R., Yang, Feng, Lu, Bai

“…Acetylcholine regulates various cognitive functions through broad cholinergic innervation. However, specific cholinergic subpopulations, circuits and molecular…”
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Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model by Papaleo, Francesco, Yang, Feng, Paterson, Clare, Palumbo, Sara, Carr, Gregory V, Wang, Yanhong, Floyd, Kirsten, Huang, Wenwei, Thomas, Craig J, Chen, Jingshan, Weinberger, Daniel R, Law, Amanda J

“…Schizophrenia is a chronic, disabling neuropsychiatric disorder with complex genetic origins. The development of strategies for genome manipulation in rodents…”
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Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats by Carr, Gregory V., Schechter, Lee E., Lucki, Irwin

“…Rationale Although selective serotonin reuptake inhibitors (SSRIs) produce clinical therapeutic effects on depression and anxiety through augmentation of…”
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Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1) gene affects dopamine signaling by Lohoff, Falk W., Carr, Gregory V., Brookshire, Bethany, Ferraro, Thomas N., Lucki, Irwin

“…•VMAT1 has recently been identified as target for neuropsychiatric disorders.•This study investigated null-mutant VMAT1 animals for effects on monoamine…”
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Inhibition of Catechol- O -methyltransferase Does Not Alter Effort-Related Choice Behavior in a Fixed Ratio/Concurrent Chow Task in Male Mice by DeBrosse, Adrienne C, Wheeler, Abigail M, Barrow, James C, Carr, Gregory V

“…Effort-related choice (ERC) tasks allow animals to choose between high-value reinforcers that require high effort to obtain and low-value/low-effort…”
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The Dopamine D5 Receptor Is Involved in Working Memory by Carr, Gregory V, Maltese, Federica, Sibley, David R, Weinberger, Daniel R, Papaleo, Francesco

“…Pharmacological studies indicate that dopamine D -like receptors (D and D ) are critically involved in cognitive function. However, the lack of pharmacological…”
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Loss of dysbindin-1 in mice impairs reward-based operant learning by increasing impulsive and compulsive behavior by Carr, Gregory V., Jenkins, Kimberly A., Weinberger, Daniel R., Papaleo, Francesco

“…► Dysbindin-1 null mice exhibit deficits in cognitive performance. ► Dysbindin-1 null mice show impaired acquisition of a reward-based, operant task. ►…”
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A Method for Touchscreen‐Based Oral Self‐Administration of Oxycodone in Mice by Afzal, Anum, Barrow, James C., Carr, Gregory V.

“…Background Opioid use disorder (OUD) is a significant public health concern and there is a critical need for new therapeutic options. Prescription opioids,…”
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Post-weaning social isolation increases ΔFosB/FosB protein expression in sex-specific patterns in the prelimbic/infralimbic cortex and hippocampus in mice by Noback, Michael, Zhang, Gongliang, White, Noelle, Barrow, James C., Carr, Gregory V.

“…•Post-weaning/adolescent social isolation increased ΔFosB in the cortex and hippocampus of adult mice.•FosB was also increased in the cortex of isolated…”
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Identification and Characterization of a Blood–Brain Barrier Penetrant Inositol Hexakisphosphate Kinase (IP6K) Inhibitor by Heitmann, Tyler, Liao, Gangling, Ernst, Glen, Poslusney, Michael, van Kralingen, Thomas, Li, Ye, Masi, Megan, DePasquale, Michael, Buchler, Ingrid, Wei, Huijun, Carr, Gregory V., Shlevkov, Evgeny, Lu, Mengsi, Jessen, Henning, Barrow, James C.

“…Inositol hexakisphosphate kinases (IP6Ks) have been studied for their role in glucose homeostasis, metabolic disease, fatty liver disease, chronic kidney…”
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Electrophysiological correlates of attention in the locus coeruleus-prelimbic cortex circuit during the rodent continuous performance test by Hallock, Henry L, Adiraju, Suhaas S, Miranda-Barrientos, Jorge, McInerney, Jessica M, Oh, Seyun, DeBrosse, Adrienne C, Li, Ye, Carr, Gregory V, Martinowich, Keri

“…Sustained attention, the ability to focus on an activity or stimulus over time, is significantly impaired in many psychiatric disorders, and there remains a…”
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Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain by Su, Yupin, DePasquale, Michael, Liao, Gangling, Buchler, Ingrid, Zhang, Gongliang, Byers, Spencer, Carr, Gregory V., Barrow, James, Wei, Huijun

“…Impaired dopamine activity in the dorsolateral prefrontal cortex (DLPFC) is thought to contribute to cognitive deficits in diseases such as schizophrenia,…”
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Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats by Carr, Gregory V., Lucki, Irwin

“…Rationale Recent evidence suggests a role for the dynorphin/kappa-opioid receptor (KOR) system in the expression of stress-induced behaviors. Wistar Kyoto…”
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Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in Wistar Kyoto Rats by CARR, Gregory V, BANGASSER, Debra A, BETHEA, Thelma, YOUNG, Matthew, VALENTINO, Rita J, LUCKI, Irwin

“…The Wistar Kyoto (WKY) rat strain is a putative genetic model of comorbid depression and anxiety. Previous research showing increased kappa-opioid receptor…”
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Antidepressant-Like Effects of -Opioid Receptor Antagonists in Wistar Kyoto Rats by Carr, Gregory V, Bangasser, Debra A, Bethea, Thelma, Young, Matthew, Valentino, Rita J, Lucki, Irwin

“…The Wistar Kyoto (WKY) rat strain is a putative genetic model of comorbid depression and anxiety. Previous research showing increased kappa-opioid receptor…”
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Paternal morphine exposure in rats reduces social play in adolescent male progeny without affecting drug-taking behavior in juvenile males or female offspring by Zeid, Dana, Toussaint, Andre B., Dressler, Carmen C., Schumacher, Samuel P., Do, Chau, Desalvo, Heather, Selamawi, Danait, Bongiovanni, Angela R., Mayberry, Hannah L., Carr, Gregory V., Wimmer, Mathieu E.

“…The ongoing opioid addiction crisis necessitates the identification of novel risk factors to improve prevention and treatment of opioid use disorder. Parental…”
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Degrading stimuli by reducing image resolution impairs performance in a rodent continuous performance test by DeBrosse, Adrienne C., Li, Ye, Wiseman, Robyn, Ross, Racine, Garrison, Sy’Keria, Hallock, Henry L., Barrow, James C., Martinowich, Keri, Carr, Gregory V.

“…Attention is a cognitive domain often disrupted in neuropsychiatric disorders and continuous performance tests (CPTs) are common clinical assays of attention…”
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Novel, non-nitrocatechol catechol-O-methyltransferase inhibitors modulate dopamine neurotransmission in the frontal cortex and improve cognitive flexibility by Byers, Spencer, Buchler, Ingrid P., DePasquale, Michael, Rowley, Helen L., Kulkarni, Rajiv S., Pinder, Lucy, Kolobova, Anna, Li, Cailian, Au, Vinh, Akuma, Daniel, Zhang, Gongliang, Wei, Huijun, Cheetham, Sharon C., Barrow, James C., Carr, Gregory V.

“…Rationale Cognitive impairment is a primary feature of many neuropsychiatric disorders and there is a need for new therapeutic options. Catechol- O…”
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Development of a PC12 Cell Based Assay for Screening Catechol‑O‑methyltransferase Inhibitors by Zhang, Gongliang, Buchler, Ingrid P, DePasquale, Michael, Wormald, Michael, Liao, Gangling, Wei, Huijun, Barrow, James C, Carr, Gregory V

“…The male rat adrenal pheochromocytoma cell-derived PC12 cell line can synthesize and release catecholamine neurotransmitters, and it has been widely used as a…”
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