Search Results - "Carr, Amanda Jayne"

Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups by Parfitt, David A., Lane, Amelia, Ramsden, Conor M., Carr, Amanda-Jayne F., Munro, Peter M., Jovanovic, Katarina, Schwarz, Nele, Kanuga, Naheed, Muthiah, Manickam N., Hull, Sarah, Gallo, Jean-Marc, da Cruz, Lyndon, Moore, Anthony T., Hardcastle, Alison J., Coffey, Peter J., Cheetham, Michael E.

“…Leber congenital amaurosis (LCA) is an inherited retinal dystrophy that causes childhood blindness. Photoreceptors are especially sensitive to an intronic…”
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Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration by da Cruz, Lyndon, Fynes, Kate, Georgiadis, Odysseas, Kerby, Julie, Luo, Yvonne H, Ahmado, Ahmad, Vernon, Amanda, Daniels, Julie T, Nommiste, Britta, Hasan, Shazeen M, Gooljar, Sakina B, Carr, Amanda-Jayne F, Vugler, Anthony, Ramsden, Conor M, Bictash, Magda, Fenster, Mike, Steer, Juliette, Harbinson, Tricia, Wilbrey, Anna, Tufail, Adnan, Feng, Gang, Whitlock, Mark, Robson, Anthony G, Holder, Graham E, Sagoo, Mandeep S, Loudon, Peter T, Whiting, Paul, Coffey, Peter J

“…An engineered patch of retinal pigment epithelium generated from human embryonic stem cells is transplanted into the eyes of two patients. Age-related macular…”
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Stem cells in retinal regeneration: past, present and future by Ramsden, Conor M, Powner, Michael B, Carr, Amanda-Jayne F, Smart, Matthew J K, da Cruz, Lyndon, Coffey, Peter J

“…Stem cell therapy for retinal disease is under way, and several clinical trials are currently recruiting. These trials use human embryonic, foetal and…”
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Development of human embryonic stem cell therapies for age-related macular degeneration by Carr, Amanda-Jayne F, Smart, Matthew J.K, Ramsden, Conor M, Powner, Michael B, da Cruz, Lyndon, Coffey, Peter J

“…Highlights • Age-related macular degeneration (AMD) is the leading cause of vision loss in older adults. Recent research for treating AMD has focused on…”
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Investigation of PTC124-mediated translational readthrough in a retinal organoid model of AIPL1-associated Leber congenital amaurosis by Leung, Amy, Sacristan-Reviriego, Almudena, Perdigão, Pedro R.L., Sai, Hali, Georgiou, Michalis, Kalitzeos, Angelos, Carr, Amanda-Jayne F., Coffey, Peter J., Michaelides, Michel, Bainbridge, James, Cheetham, Michael E., van der Spuy, Jacqueline

“…Leber congenital amaurosis type 4 (LCA4), caused by AIPL1 mutations, is characterized by severe sight impairment in infancy and rapidly progressing…”
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Annexin A8 regulates Wnt signaling to maintain the phenotypic plasticity of retinal pigment epithelial cells by Lueck, Katharina, Carr, Amanda-Jayne F., Yu, Lu, Greenwood, John, Moss, Stephen E.

“…Wnt signalling mediates complex cell-cellinteractions during development and proliferation. Annexin A8 (AnxA8), a calcium-dependent phospholipid-binding…”
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Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat by Carr, Amanda-Jayne, Vugler, Anthony A, Hikita, Sherry T, Lawrence, Jean M, Gias, Carlos, Chen, Li Li, Buchholz, David E, Ahmado, Ahmad, Semo, Ma'ayan, Smart, Matthew J K, Hasan, Shazeen, da Cruz, Lyndon, Johnson, Lincoln V, Clegg, Dennis O, Coffey, Pete J

“…Transformation of somatic cells with a set of embryonic transcription factors produces cells with the pluripotent properties of embryonic stem cells (ESCs)…”
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Translational read-through of the RP2 Arg120stop mutation in patient iPSC-derived retinal pigment epithelium cells by Schwarz, Nele, Carr, Amanda-Jayne, Lane, Amelia, Moeller, Fabian, Chen, Li Li, Aguilà, Mònica, Nommiste, Britta, Muthiah, Manickam N, Kanuga, Naheed, Wolfrum, Uwe, Nagel-Wolfrum, Kerstin, da Cruz, Lyndon, Coffey, Peter J, Cheetham, Michael E, Hardcastle, Alison J

“…Mutations in the RP2 gene lead to a severe form of X-linked retinitis pigmentosa. RP2 patients frequently present with nonsense mutations and no treatments are…”
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Bestrophin1: A Gene that Causes Many Diseases by Smith, Joseph J, Nommiste, Britta, Carr, Amanda-Jayne F

“…Bestrophinopathies are a group of clinically distinct inherited retinal dystrophies that lead to the gradual loss of vision in and around the macular area…”
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Elucidating the phenomenon of HESC-derived RPE: Anatomy of cell genesis, expansion and retinal transplantation by Vugler, Anthony, Carr, Amanda-Jayne, Lawrence, Jean, Chen, Li Li, Burrell, Kelly, Wright, Andrew, Lundh, Peter, Semo, Ma'ayan, Ahmado, Ahmad, Gias, Carlos, da Cruz, Lyndon, Moore, Harry, Andrews, Peter, Walsh, James, Coffey, Peter

“…Healthy Retinal Pigment Epithelium (RPE) cells are required for proper visual function and the phenomenon of RPE derivation from Human Embryonic Stem Cells…”
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Regulation of retinal pigment epithelial cell phenotype by Annexin A8 by Lueck, Katharina, Carr, Amanda-Jayne F., Stampoulis, Dimitrios, Gerke, Volker, Rescher, Ursula, Greenwood, John, Moss, Stephen E.

“…The retinoic acid derivative fenretinide (FR) is capable of transdifferentiating cultured retinal pigment epithelial (RPE) cells towards a neuronal-like…”
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Bestrophinopathies: perspectives on clinical disease, Bestrophin-1 function and developing therapies by Singh Grewal, Simranjeet, Smith, Joseph J., Carr, Amanda-Jayne F.

“…Bestrophinopathies are a group of clinically distinct inherited retinal dystrophies that typically affect the macular region, an area synonymous with central…”
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Induction of differentiation by pyruvate and DMEM in the human retinal pigment epithelium cell line ARPE-19 by Ahmado, Ahmad, Carr, Amanda-Jayne, Vugler, Anthony A, Semo, Ma'ayan, Gias, Carlos, Lawrence, Jean M, Chen, Li Li, Chen, Fred K, Turowski, Patric, da Cruz, Lyndon, Coffey, Peter J

“…Cultured retinal pigment epithelium (RPE) may become a therapeutic option for transplantation in retinal disease. However maintaining a native RPE phenotype in…”
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Imaging of single light-responsive clock cells reveals fluctuating free-running periods by Whitmore, David, Carr, Amanda-Jayne F

“…Zebrafish tissues and cell lines contain circadian clocks that respond directly to light. Using fluorescence-activated cell sorting, we have isolated clonal…”
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Establishment and characterization of an iPSC line (UCLi023-A) derived from a Late-Onset Retinal Degeneration patient carrying a founder mutation in C1QTNF5 by Alonso-Carriazo Fernández, Ana, Ashley-Norman, Phoebe, Butt, Zaynab, Moosajee, Mariya, Carr, Amanda-Jayne Francis

“…Late-Onset Retinal Degeneration (L-ORD) is a rare autosomal dominant macular disease, with most cases being caused by a founder mutation in C1QTNF5. Initial…”
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Mislocalisation of BEST1 in iPSC-derived retinal pigment epithelial cells from a family with autosomal dominant vitreoretinochoroidopathy (ADVIRC) by Carter, David A., Smart, Matthew J. K., Letton, William V. G., Ramsden, Conor M., Nommiste, Britta, Chen, Li Li, Fynes, Kate, Muthiah, Manickam N., Goh, Pollyanna, Lane, Amelia, Powner, Michael B., Webster, Andrew R., da Cruz, Lyndon, Moore, Anthony T., Coffey, Peter J., Carr, Amanda-Jayne F.

“…Autosomal dominant vitreoretinochoroidopathy (ADVIRC) is a rare, early-onset retinal dystrophy characterised by distinct bands of circumferential pigmentary…”
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Rescue of the MERTK phagocytic defect in a human iPSC disease model using translational read-through inducing drugs by Ramsden, Conor M., Nommiste, Britta, R. Lane, Amelia, Carr, Amanda-Jayne F., Powner, Michael B., J. K. Smart, Matthew, Chen, Li Li, Muthiah, Manickam N., Webster, Andrew R., Moore, Anthony T., Cheetham, Michael E., da Cruz, Lyndon, Coffey, Peter J.

“…Inherited retinal dystrophies are an important cause of blindness, for which currently there are no effective treatments. In order to study this heterogeneous…”
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Degeneration of cortical function in the Royal College of Surgeons rat by Gias, Carlos, Vugler, Anthony, Lawrence, Jean, Carr, Amanda Jayne, Chen, Li Li, Ahmado, Ahmed, Semo, Ma’ayan, Coffey, Peter J.

“…► Royal College of Surgeons rat brain electrophysiology. ► Early degeneration in the cortical processing to gratings stimulation. ► Cortical processing to…”
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Using Stem Cells to Model Diseases of the Outer Retina by Yvon, Camille, Ramsden, Conor M, Lane, Amelia, Powner, Michael B, da Cruz, Lyndon, Coffey, Peter J, Carr, Amanda-Jayne F

“…Retinal degeneration arises from the loss of photoreceptors or retinal pigment epithelium (RPE). It is one of the leading causes of irreversible blindness…”
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Novel therapies for Bestrophinopathies by Carr, Amanda‐Jayne

“…Bestrophinopathies are a group of clinically distinct diseases caused by mutations in Bestrophin1 (BEST1). BEST1 is expressed exclusively in the retinal…”
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