Search Results - "Carr, Adam J."

Harnessing Clickable Acylated Glycerol Probes as Chemical Tools for Tracking Glycerolipid Metabolism by Ancajas, Christelle F., Carr, Adam J., Lou, Jinchao, Sagar, Ruhani, Zhou, Yue, Reynolds, Todd B., Best, Michael D.

“…We report the use of clickable monoacylglycerol (MAG) analogs as probes for the labeling of glycerolipids during lipid metabolism. Incorporation of azide tags…”
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Labeling of Phosphatidylinositol Lipid Products in Cells through Metabolic Engineering by Using a Clickable myo‐Inositol Probe by Ricks, Tanei J., Cassilly, Chelsi D., Carr, Adam J., Alves, Daiane S., Alam, Shahrina, Tscherch, Kathrin, Yokley, Timothy W., Workman, Cameron E., Morrell‐Falvey, Jennifer L., Barrera, Francisco N., Reynolds, Todd B., Best, Michael D.

“…Phosphatidylinositol (PI) lipids control critical biological processes, so aberrant biosynthesis often leads to disease. As a result, the capability to track…”
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Fluorogenic XY-69 in Lipid Vesicles for Measuring Activity of Phospholipase C Isozymes by Carr, Adam J, Siraliev-Perez, Edhriz, Huang, Weigang, Sondek, John, Zhang, Qisheng

“…Mammalian phospholipase C (PLC) isozymes are major signaling nodes that regulate a wide range of cellular processes. Dysregulation of PLC activity has been…”
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“Fix and Click” for Assay of Sphingolipid Signaling in Single Primary Human Intestinal Epithelial Cells by Gallion, Luke A, Wang, Yuli, Massaro, Angelo, Yao, Ming, Petersen, Brae V, Zhang, Quanzheng, Huang, Weigang, Carr, Adam J, Zhang, Qisheng, Allbritton, Nancy L

“…Capillary electrophoresis with fluorescence detection (CE-F) is a powerful method to measure enzyme activation in single cells. However, cellular enzymatic…”
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Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease by Tsai, Andy P., Dong, Chuanpeng, Lin, Peter Bor-Chian, Oblak, Adrian L., Viana Di Prisco, Gonzalo, Wang, Nian, Hajicek, Nicole, Carr, Adam J., Lendy, Emma K., Hahn, Oliver, Atkins, Micaiah, Foltz, Aulden G., Patel, Jheel, Xu, Guixiang, Moutinho, Miguel, Sondek, John, Zhang, Qisheng, Mesecar, Andrew D., Liu, Yunlong, Atwood, Brady K., Wyss-Coray, Tony, Nho, Kwangsik, Bissel, Stephanie J., Lamb, Bruce T., Landreth, Gary E.

“…Genetic association studies have demonstrated the critical involvement of the microglial immune response in Alzheimer’s disease (AD) pathogenesis…”
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A High-Throughput Assay to Identify Allosteric Inhibitors of the PLC‑γ Isozymes Operating at Membranes by Huang, Weigang, Carr, Adam J, Hajicek, Nicole, Sokolovski, Miri, Siraliev-Perez, Edhriz, Hardy, P. Brian, Pearce, Kenneth H, Sondek, John, Zhang, Qisheng

“…The two phospholipase C-γ (PLC-γ) isozymes are major signaling hubs and emerging therapeutic targets for various diseases, yet there are no selective…”
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Cellular Labeling of Phosphatidylserine Using Clickable Serine Probes by Ancajas, Christelle F., Alam, Shahrina, Alves, Daiane S., Zhou, Yue, Wadsworth, Nicholas M., Cassilly, Chelsi D., Ricks, Tanei J., Carr, Adam J., Reynolds, Todd B., Barrera, Francisco N., Best, Michael D.

“…Phosphatidylserine (PS) is a key lipid that plays important roles in disease-related biological processes, and therefore, the means to track PS in live cells…”
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Calcium‐Responsive Liposomes via a Synthetic Lipid Switch by Lou, Jinchao, Carr, Adam J., Watson, Alexa J., Mattern‐Schain, Samuel I., Best, Michael D.

“…Liposomal drug delivery would benefit from enhanced control over content release. Here, we report a novel avenue for triggering release driven by chemical…”
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Artificial Membrane Fusion Triggered by Strain-Promoted Alkyne–Azide Cycloaddition by Whitehead, Stuart A, McNitt, Christopher D, Mattern-Schain, Samuel I, Carr, Adam J, Alam, Shahrina, Popik, Vladimir V, Best, Michael D

“…Artificial systems for controlled membrane fusion applicable for drug delivery would ideally use triggers that are orthogonal to biology. To apply the…”
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Labeling of Phosphatidylinositol Lipid Products in Cells via Metabolic Engineering using a Clickable myo-Inositol Probe by Ricks, Tanei J., Cassilly, Chelsi D., Carr, Adam J., Alves, Daiane S., Alam, Shahrina, Tscherch, Kathrin, Yokley, Timothy W., Workman, Cameron E., Morrell-Falvey, Jennifer L., Barrera, Francisco N., Reynolds, Todd B., Best, Michael D.

“…Phosphatidylinositol (PI) lipids control critical biological processes and thus aberrant biosynthesis often leads to disease. As a result, the ability to track…”
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Labeling of Phosphatidylinositol Lipid Products in Cells through Metabolic Engineering by Using a Clickable myo-Inositol Probe by Ricks, Tanei, Cassilly, Chelsi D., Carr, Adam J., Alves, Daiane S., Alam, Shahrina, Tscherch, Kathrin, Yokley, Timothy W., Workman, Cameron E., Morrell-Falvey, Jennifer L., Barrera, Francisco N., Reynolds, Todd B., Best, Michael D.

“…Phosphatidylinositol (PI) lipids control critical biological processes, so aberrant biosynthesis often leads to disease. As a result, the capability to track…”
Get full text