Search Results - "Carpenter, Valerie J"

Therapy-Induced Senescence: An "Old" Friend Becomes the Enemy by Saleh, Tareq, Bloukh, Sarah, Carpenter, Valerie J, Alwohoush, Enas, Bakeer, Jomana, Darwish, Sarah, Azab, Belal, Gewirtz, David A

“…For the past two decades, cellular senescence has been recognized as a central component of the tumor cell response to chemotherapy and radiation…”
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Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐XL–BAX interaction by Saleh, Tareq, Carpenter, Valerie J., Tyutyunyk‐Massey, Liliya, Murray, Graeme, Leverson, Joel D., Souers, Andrew J., Alotaibi, Moureq R., Faber, Anthony C., Reed, Jason, Harada, Hisashi, Gewirtz, David A.

“…Senescent tumor cells can be selectively eliminated by the BH3 mimetic, ABT‐263 (navitoclax), via senolysis. We show that ABT‐263 inhibits the interaction…”
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Expression of therapy-induced senescence markers in breast cancer samples upon incomplete response to neoadjuvant chemotherapy by Saleh, Tareq, Alhesa, Ahmad, Al-Balas, Mahmoud, Abuelaish, Omar, Mansour, Ahmad, Awad, Heyam, El-Sadoni, Mohammed, Carpenter, Valerie J, Azab, Bilal

“…Senescence is a cell stress response induced by replicative, oxidative, oncogenic, and genotoxic stresses. Tumor cells undergo senescence in response to…”
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Targeting tumor cell senescence and polyploidy as potential therapeutic strategies by Saleh, Tareq, Carpenter, Valerie J., Bloukh, Sarah, Gewirtz, David A.

“…Senescence is a unique state of growth arrest that develops in response to a plethora of cellular stresses, including replicative exhaustion, oxidative injury,…”
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Potential Use of Senolytics for Pharmacological Targeting of Precancerous Lesions by Saleh, Tareq, Carpenter, Valerie J

“…Senescence is a cell state that contributes to several homeostatic and pathologic processes. In addition to being induced in somatic cells in response to…”
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Senolytics for Cancer Therapy: Is All That Glitters Really Gold? by Carpenter, Valerie J, Saleh, Tareq, Gewirtz, David A

“…Senolytics represent a group of mechanistically diverse drugs that can eliminate senescent cells, both in tumors and in several aging-related pathologies…”
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Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X L -BAX interaction by Saleh, Tareq, Carpenter, Valerie J, Tyutyunyk-Massey, Liliya, Murray, Graeme, Leverson, Joel D, Souers, Andrew J, Alotaibi, Moureq R, Faber, Anthony C, Reed, Jason, Harada, Hisashi, Gewirtz, David A

“…Tumor cells undergo senescence in response to both conventional and targeted cancer therapies. The induction of senescence in response to cancer therapy can…”
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Senescence and castration resistance in prostate cancer: A review of experimental evidence and clinical implications by Carpenter, Valerie J., Patel, Bhaumik B., Autorino, Riccardo, Smith, Steven C., Gewirtz, David A., Saleh, Tareq

“…The development of Castration-Resistant Prostate Cancer (CRPC) remains a major challenge in the treatment of this disease. While Androgen Deprivation Therapy…”
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HIV-1 Tat and Morphine Differentially Disrupt Pyramidal Cell Structure and Function and Spatial Learning in Hippocampal Area CA1: Continuous versus Interrupted Morphine Exposure by Marks, William D, Paris, Jason J, Barbour, Aaron J, Moon, Jean, Carpenter, Valerie J, McLane, Virginia D, Lark, Arianna R S, Nass, Sara R, Zhang, Jingli, Yarotskyy, Viktor, McQuiston, A Rory, Knapp, Pamela E, Hauser, Kurt F

“…About half the people infected with human immunodeficiency virus (HIV) have neurocognitive deficits that often include memory impairment and hippocampal…”
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Abstract 902: The antiandrogen bicalutamide induces senescence in LNCaP cells and quiescence in Myc CaP cells by Carpenter, Valerie J., Saleh, Tareq, Gewirtz, David A.

“…Abstract The survival benefits in prostate cancer (PCa) conferred by androgen deprivation therapies (ADT) and antiandrogens are often blunted by the…”
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