Search Results - "Carpenter, Phillip B"

Regulation of DNA Repair through DeSUMOylation and SUMOylation of Replication Protein A Complex by Dou, Hong, Huang, Chao, Singh, Melissa, Carpenter, Phillip B., Yeh, Edward T.H.

“…The replication protein A complex (RPA) plays a crucial role in DNA replication and damage response. However, it is not known whether this complex is regulated…”
Get full text

The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres by Rai, Rekha, Zheng, Hong, He, Hua, Luo, Ying, Multani, Asha, Carpenter, Phillip B, Chang, Sandy

“…Repair of DNA double‐stranded breaks (DSBs) is crucial for the maintenance of genome stability. DSBs are repaired by either error prone non‐homologous…”
Get full text

Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function by Lucio-Eterovic, Agda Karina, Singh, Melissa M., Gardner, Jeffrey E., Veerappan, Chendhore S., Rice, Judd C., Carpenter, Phillip B.

“…The NSD (nuclear receptor-binding SET domain protein) family encodes methyltransferases that are important in multiple aspects of development and disease…”
Get full text

Catalytic Function of the PR-Set7 Histone H4 Lysine 20 Monomethyltransferase Is Essential for Mitotic Entry and Genomic Stability by Houston, Sabrina I., McManus, Kirk J., Adams, Melissa M., Sims, Jennifer K., Carpenter, Phillip B., Hendzel, Michael J., Rice, Judd C.

“…Histone-modifying enzymes play a critical role in modulating chromatin dynamics. In this report we demonstrate that one of these enzymes, PR-Set7, and its…”
Get full text

53BP1, a Mediator of the DNA Damage Checkpoint by Wang, Bin, Matsuoka, Shuhei, Carpenter, Phillip B., Elledge, Stephen J.

“…53BP1 binds to the tumor suppressor protein p53 and has a potential role in DNA damage responses. We used small interfering RNA (siRNA) directed against 53BP1…”
Get full text

Understanding the language of Lys36 methylation at histone H3 by Wagner, Eric J., Carpenter, Phillip B.

“…Key Points Methylation of Lys36 on histone H3 (H3K36) is an important modification for multiple cellular processes. To date, at least eight enzymes have been…”
Get full text

H2AX Prevents DNA Breaks from Progressing to Chromosome Breaks and Translocations by Franco, Sonia, Gostissa, Monica, Zha, Shan, Lombard, David B., Murphy, Michael M., Zarrin, Ali A., Yan, Catherine, Tepsuporn, Suprawee, Morales, Julio C., Adams, Melissa M., Lou, Zhenkun, Bassing, Craig H., Manis, John P., Chen, Junjie, Carpenter, Phillip B., Alt, Frederick W.

“…Histone H2AX promotes DNA double-strand break (DSB) repair and immunoglobulin heavy chain (IgH) class switch recombination (CSR) in B-lymphocytes. CSR requires…”
Get full text

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination by Manis, John P, Morales, Julio C, Xia, Zhenfang, Kutok, Jeffery L, Alt, Frederick W, Carpenter, Phillip B

“…The mammalian protein 53BP1 is activated in many cell types in response to genotoxic stress, including DNA double-strand breaks (DSBs). We now examine…”
Get full text

Tying the loose ends together in DNA double strand break repair with 53BP1 by Adams, Melissa M, Carpenter, Phillip B

“…To maintain genomic stability and ensure the fidelity of chromosomal transmission, cells respond to various forms of genotoxic stress, including DNA…”
Get full text

Role for the BRCA1 C-terminal Repeats (BRCT) Protein 53BP1 in Maintaining Genomic Stability by Morales, Julio C., Xia, Zhenfang, Lu, Tao, Aldrich, Melissa B., Wang, Bin, Rosales, Corina, Kellems, Rodney E., Hittelman, Walter N., Elledge, Stephen J., Carpenter, Phillip B.

“…p53-binding protein-1 (53BP1) is phosphorylated in response to DNA damage and rapidly relocalizes to presumptive sites of DNA damage along with Mre11 and the…”
Get full text

An open and shut case for the role of NSD proteins as oncogenes by Lucio-Eterovic, Agda Karina, Carpenter, Phillip B.

“…The three components of the mammalian nuclear SET domain containing protein (NSD) family have been implicated in multiple diseases and cancers, but very little…”
Get full text

53BP1 and p53 Synergize to Suppress Genomic Instability and Lymphomagenesis by Morales, Julio C., Franco, Sonia, Murphy, Michael M., Bassing, Craig H., Mills, Kevin D., Adams, Melissa M., Walsh, Nicole C., Manis, John P., Rassidakis, George Z., Alt, Frederick W., Carpenter, Phillip B.

“…p53-binding protein 1 (53BP1) participates in the cellular response to DNA double-stranded breaks where it associates with various DNA repair/cell cycle…”
Get full text

The Xenopus Cdc6 Protein Is Essential for the Initiation of a Single Round of DNA Replication in Cell-Free Extracts by Coleman, Thomas R, Carpenter, Phillip B, Dunphy, William G

“…We have cloned a Xenopus Cdc6 homolog (Xcdc6) and characterized its role in DNA replication with Xenopus egg extracts. Immunodepletion of Xcdc6 abolishes…”
Get full text

53BP1 Oligomerization is Independent of its Methylation by PRMT1 by Adams, Melissa M., Wang, Bin, Xia, Zhenfang, Morales, Julio C., Lu, Xiongbin, Donehower, Lawrence A., Bochar, Daniel A., Elledge, Stephen J., Carpenter, Phillip B.

“…p53 binding protein 1 (53BP1) participates in the repair of DNA double stranded breaks (DSBs)where it is recruited to or near sites of DNA damage. Although…”
Get full text

Improved performance in and preference for using think‐pair‐share in a flipped classroom by Carpenter, Phillip B., Poliak, Aaron, Wang, Litao, Ownby, Allison R., Hsieh, Peggy

Get full text

53BP1 Contributes to Igh Locus Chromatin Topology during Class Switch Recombination by Feldman, Scott, Wuerffel, Robert, Achour, Ikbel, Wang, Lili, Carpenter, Phillip B, Kenter, Amy L

“…In B lymphocytes, Ig class switch recombination (CSR) is induced by activation-induced cytidine deaminase, which initiates a cascade of events leading to DNA…”
Get full text

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1 by Fernandez-Capetillo, Oscar, Chen, Hua-Tang, Celeste, Arkady, Ward, Irene, Romanienko, Peter J, Morales, Julio C, Naka, Kazuhito, Xia, Zhenfang, Camerini-Otero, R Daniel, Motoyama, Noboru, Carpenter, Phillip B, Bonner, William M, Chen, Junjie, Nussenzweig, André

“…Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR), including the initiation of cell…”
Get full text

hSnm1 Colocalizes and Physically Associates with 53BP1 before and after DNA Damage by Richie, Christopher T., Peterson, Carolyn, Lu, Tao, Hittelman, Walter N., Carpenter, Phillip B., Legerski, Randy J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1 by Xia, Zhenfang, Morales, Julio C., Dunphy, William G., Carpenter, Phillip B.

“…In a screen designed to discover suppressors of mitotic catastrophe, we identified the Xenopus ortholog of 53BP1 (X53BP1), a BRCT protein previously identified…”
Get full text

Role for a Xenopus Orc2-related protein in controlling DNA replication by Carpenter, Phillip B, Mueller, Paul R, Dunphy, William G

“…The six-subunit origin recognition complex (ORC) is essential for the initiation of DNA replication at specific origins in the budding yeast Saccharomyces…”
Get full text