Search Results - "Carpenter, Keri L.H."

Aptamer-modified gold nanoparticles for rapid aggregation-based detection of inflammation: an optical assay for interleukin-6 by Giorgi-Coll, Susan, Marín, María J., Sule, Olajumoke, Hutchinson, Peter J., Carpenter, Keri L.H.

“…A proof-of-concept aptamer-based optical assay is described for the determination of the immuno signalling molecule interleukin-6 (IL-6), a key marker of acute…”
Get full text

Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury by Helmy, Adel, De Simoni, Maria-Grazia, Guilfoyle, Mathew R, Carpenter, Keri L H, Hutchinson, Peter J

“…There is an increasing recognition that following traumatic brain injury, a cascade of inflammatory mediators is produced, and contributes to the pathological…”
Get full text

A Comparison of Oxidative Lactate Metabolism in Traumatically Injured Brain and Control Brain by Jalloh, Ibrahim, Helmy, Adel, Howe, Duncan J, Shannon, Richard J, Grice, Peter, Mason, Andrew, Gallagher, Clare N, Murphy, Michael P, Pickard, John D, Menon, David K, Carpenter, T Adrian, Hutchinson, Peter J, Carpenter, Keri L H

“…Metabolic abnormalities occur after traumatic brain injury (TBI). Glucose is conventionally regarded as the major energy substrate, although lactate can also…”
Get more information

Heparin-gold nanoparticles for enhanced microdialysis sampling by Giorgi-Coll, Susan, Blunt-Foley, Holly, Hutchinson, Peter J., Carpenter, Keri L.H.

“…Cerebral microdialysis is a sampling technique which offers much potential for understanding inflammatory pathophysiology following traumatic brain injury…”
Get full text

Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury by Orešič, Matej, Posti, Jussi P., Kamstrup-Nielsen, Maja H., Takala, Riikka S.K., Lingsma, Hester F., Mattila, Ismo, Jäntti, Sirkku, Katila, Ari J., Carpenter, Keri L.H., Ala-Seppälä, Henna, Kyllönen, Anna, Maanpää, Henna-Riikka, Tallus, Jussi, Coles, Jonathan P., Heino, Iiro, Frantzén, Janek, Hutchinson, Peter J., Menon, David K., Tenovuo, Olli, Hyötyläinen, Tuulia

“…Traumatic brain injury (TBI) is a major cause of death and disability worldwide, especially in children and young adults. TBI is an example of a medical…”
Get full text

Interaction between brain chemistry and physiology after traumatic brain injury: impact of autoregulation and microdialysis catheter location by Timofeev, Ivan, Czosnyka, Marek, Carpenter, Keri L H, Nortje, Jurgens, Kirkpatrick, Peter J, Al-Rawi, Pippa G, Menon, David K, Pickard, John D, Gupta, Arun K, Hutchinson, Peter J

“…Bedside monitoring of cerebral metabolism in traumatic brain injury (TBI) with microdialysis is gaining wider clinical acceptance. The objective of this study…”
Get more information

Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery by Helmy, Adel, Carpenter, Keri L H, Skepper, Jeremy N, Kirkpatrick, Peter J, Pickard, John D, Hutchinson, Peter J

“…Cerebral microdialysis is a monitoring technique with expanding clinical and research utility following traumatic brain injury. This study's aim was to…”
Get more information

Quantification of pyruvate in-vitro using mid-infrared spectroscopy: Developing a system for microdialysis monitoring in traumatic brain injury patients by Zimphango, Chisomo, Alimagham, Farah C., Hutter, Tanya, Hutchinson, Peter J., Carpenter, Keri L.H.

“…Complex metabolic disruption is a major aspect of the pathophysiology of traumatic brain injury (TBI). Pyruvate is an intermediate in glucose metabolism and…”
Get full text

Mildly oxidised LDL induces more macrophage death than moderately oxidised LDL: roles of peroxidation, lipoprotein‐associated phospholipase A2 and PPARγ by Carpenter, Keri L.H, Challis, Iain R, Arends, Mark J

“…Death of macrophages and smooth muscle cells (SMC) can lead to progression of atherosclerosis. Mildly oxidised low‐density lipoprotein (mildly‐oxLDL) induced…”
Get full text

Oxysterol profiles of normal human arteries, fatty streaks and advanced lesions by Garcia-Cruset, S, Carpenter, K L, Guardiola, F, Stein, B K, Mitchinson, M J

“…Human atherosclerotic lesions of different stages have quantitative differences in cholesterol and oxysterol content, but information on the oxysterol profile…”
Get more information

Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy by Edlmann, Ellie, Giorgi-Coll, Susan, Whitfield, Peter C, Carpenter, Keri L H, Hutchinson, Peter J

“…Chronic subdural haematoma (CSDH) is an encapsulated collection of blood and fluid on the surface of the brain. Historically considered a result of head…”
Get full text

Potency of arachidonic acid in polyunsaturated fatty acid-induced death of human monocyte–macrophages: implications for atherosclerosis by Muralidhar, Balaji, Carpenter, Keri L.H., Müller, Karin, Skepper, Jeremy N., Arends, Mark J.

“…Evidence suggests that oxidation of LDL is involved in the progression of atherosclerosis by inducing apoptosis in macrophages. Polyunsaturated fatty acids…”
Get full text

Candidate neuroinflammatory markers of cerebral autoregulation dysfunction in human acute brain injury by Smith, Claudia A, Carpenter, Keri LH, Hutchinson, Peter J, Smielewski, Peter, Helmy, Adel

“…The loss of cerebral autoregulation (CA) is a common and detrimental secondary injury mechanism following acute brain injury and has been associated with worse…”
Get full text

The carotenoids β-carotene, canthaxanthin and zeaxanthin inhibit macrophage-mediated LDL oxidation by Carpenter, Keri L.H, van der Veen, Carina, Hird, Rachel, Dennis, Ian F, Ding, Tina, Mitchinson, Malcolm J

“…Human monocyte-macrophages were incubated for 24 h in Ham's F-10 medium with human low-density lipoprotein (LDL) in the presence or absence of β-carotene,…”
Get full text

Recombinant Human Interleukin-1 Receptor Antagonist in Severe Traumatic Brain Injury: A Phase II Randomized Control Trial by Helmy, Adel, Guilfoyle, Mathew R, Carpenter, Keri LH, Pickard, John D, Menon, David K, Hutchinson, Peter J

“…Traumatic brain injury (TBI) is the commonest cause of death and disability in those aged under 40 years. Interleukin-1 receptor antagonist (IL1ra) is an…”
Get full text

Glycolysis and the significance of lactate in traumatic brain injury by Carpenter, Keri L H, Jalloh, Ibrahim, Hutchinson, Peter J

“…In traumatic brain injury (TBI) patients, elevation of the brain extracellular lactate concentration and the lactate/pyruvate ratio are well-recognized, and…”
Get full text

Characterising the dynamics of cerebral metabolic dysfunction following traumatic brain injury: A microdialysis study in 619 patients by Guilfoyle, Mathew R, Helmy, Adel, Donnelly, Joseph, Stovell, Matthew G, Timofeev, Ivan, Pickard, John D, Czosnyka, Marek, Smielewski, Peter, Menon, David K, Carpenter, Keri L H, Hutchinson, Peter J

“…Traumatic brain injury (TBI) is a major cause of death and disability, particularly amongst young people. Current intensive care management of TBI patients is…”
Get full text

Recombinant human interleukin-1 receptor antagonist promotes M1 microglia biased cytokines and chemokines following human traumatic brain injury by Helmy, Adel, Guilfoyle, Mathew R, Carpenter, Keri LH, Pickard, John D, Menon, David K, Hutchinson, Peter J

“…Interleukin-1 receptor antagonist (IL1ra) has demonstrated efficacy in a wide range of animal models of neuronal injury. We have previously published a…”
Get full text

Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients by TIMOFEEV, Ivan, CARPENTER, Keri L. H, GUPTA, Arun K, HUTCHINSON, Peter J, NORTJE, Jürgens, AL-RAWI, Pippa G, O'CONNELL, Mark T, CZOSNYKA, Marek, SMIELEWSKI, Peter, PICKARD, John D, MENON, David K, KIRKPATRICK, Peter J

“…Secondary insults can adversely influence outcome following severe traumatic brain injury. Monitoring of cerebral extracellular chemistry with microdialysis…”
Get full text

The cytokine response to human traumatic brain injury: temporal profiles and evidence for cerebral parenchymal production by Helmy, Adel, Carpenter, Keri LH, Menon, David K, Pickard, John D, Hutchinson, Peter JA

“…The role of neuroinflammation is increasingly being recognised in a diverse range of cerebral pathologies, including traumatic brain injury (TBI). We used…”
Get full text