Search Results - "Carp, Richard"
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1
Studying Rome While It Burns
Published in Religions (Basel, Switzerland ) (01-04-2024)“…The call for papers for this Special Issue Iidentifies contemporary humanity as experiencing a global “biogeochemical … political, economic, technological,…”
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Cellular Prion Protein Combined with Galectin-3 and -6 Affects the Infectivity Titer of an Endogenous Retrovirus Assayed in Hippocampal Neuronal Cells
Published in PloS one (09-12-2016)“…Prion diseases are infectious and fatal neurodegenerative diseases which require the cellular prion protein, PrPC, for development of diseases. The current…”
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3
Phosphatidylinositol-glycan-phospholipase D is involved in neurodegeneration in prion disease
Published in PloS one (13-04-2015)“…PrPSc is formed from a normal glycosylphosphatidylinositol (GPI)-anchored prion protein (PrPC) by a posttranslational modification. Most GPI-anchored proteins…”
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Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases
Published in Biochemical journal (15-07-2012)“…The citrullination of enolase by PAD (peptidylarginine deiminase) has emerged as an important post-translational modification in human disorders; however, the…”
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5
Oxidative stress impairs autophagic flux in prion protein-deficient hippocampal cells
Published in Autophagy (01-10-2012)“…We previously reported that autophagy is upregulated in Prnp-deficient (Prnp 0/0 ) hippocampal neuronal cells in comparison to cellular prion protein (PrP C…”
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Assessment of social interaction and anxiety-like behavior in senescence-accelerated-prone and -resistant mice
Published in Physiology & behavior (13-06-2013)“…Abstract Two members of the senescence-accelerated mouse group, SAMP8 and SAMP10, are characterized by learning and memory deficits, while the SAMR1 strain is…”
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Dysfunction of mitochondrial dynamics in the brains of scrapie-infected mice
Published in Biochemical and biophysical research communications (30-05-2014)“…•Mfn1 and Fis1 are significantly increased in the hippocampal region of the ME7 prion-infected brain, whereas Dlp1 is significantly decreased in the infected…”
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Complete genome sequences of new xenotropic murine leukemia viruses from the senescence-accelerated mouse (SAM): molecular and phylogenetic analyses
Published in PloS one (05-02-2013)“…Approximately 10% of the mouse genome is constituted by endogenous retroviruses (ERVs), and a number of mouse ERVs remain active. Many copies of endogenous…”
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Peptidylarginine deiminase and protein citrullination in prion diseases: Strong evidence of neurodegeneration
Published in Prion (01-01-2013)“…The post-translational citrullination (deimination) process is mediated by peptidylarginine deiminases (PADs), which convert peptidylarginine into…”
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10
Clearance and prevention of prion infection in cell culture by anti-PrP antibodies
Published in The European journal of neuroscience (01-05-2006)“…Prion diseases are transmissible and invariably fatal neurodegenerative disorders associated with a conformational transformation of the cellular prion protein…”
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N(ε)-Carboxymethyl Modification of Lysine Residues in Pathogenic Prion Isoforms
Published in Molecular neurobiology (01-07-2016)“…The most prominent hallmark of prion diseases is prion protein conversion and the subsequent deposition of the altered prions, PrP(Sc), at the pathological…”
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The prevalence of human endogenous retroviruses in cerebrospinal fluids from patients with sporadic Creutzfeldt–Jakob disease
Published in Journal of clinical virology (01-02-2010)“…Abstract Background About 8% of human genome is constituted by retroviral sequences. Some of these have been classified as human endogenous retroviruses…”
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Subcellular Localization of Peptidylarginine Deiminase 2 and Citrullinated Proteins in Brains of Scrapie-Infected Mice: Nuclear Localization of PAD2 and Membrane Fraction-Enriched Citrullinated Proteins
Published in Journal of neuropathology and experimental neurology (01-02-2011)“…Peptidylarginine deiminase (PAD) and citrullinated proteins have emerged as key molecules in various human diseases, but detailed subcellular localizations of…”
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14
Semi-purification procedures of prions from a prion-infected brain using sucrose has no influence on the nonenzymatic glycation of the disease-associated prion isoform
Published in Biological chemistry (01-01-2016)“…Previous studies have shown that the Nε-carboxymethyl group is linked to not only one or more N-terminal Lys residues but also to one or more Lys residues of…”
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Accumulation of Citrullinated Proteins by Up-Regulated Peptidylarginine Deiminase 2 in Brains of Scrapie-Infected Mice: A Possible Role in Pathogenesis
Published in The American journal of pathology (01-10-2008)“…Peptidylarginine deiminases (PADs), which are a group of posttranslational modification enzymes, are involved in protein citrullination (deimination) by the…”
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Involvement of peptidylarginine deiminase-mediated post-translational citrullination in pathogenesis of sporadic Creutzfeldt-Jakob disease
Published in Acta neuropathologica (01-02-2010)“…Peptidylarginine deiminases (PADs)-mediated post-translational citrullination processes play key roles in protein functions and structural stability through…”
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Copper Chelation Delays the Onset of Prion Disease
Published in The Journal of biological chemistry (21-11-2003)“…The prion protein (PrP) binds copper and under some conditions copper can facilitate its folding into a more protease resistant form. Hence, copper levels may…”
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Upregulation of Connexin 43 Expression Via C-Jun N-Terminal Kinase Signaling in Prion Disease
Published in Journal of Alzheimer's disease (01-01-2016)“…Prion infection leads to neuronal cell death, glial cell activation, and the accumulation of misfolded prion proteins. However, the altered cellular…”
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Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus elaphus nelsoni) PrPC
Published in Journal of general virology (01-12-2006)“…1 New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA 2 Case Western Reserve…”
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Accelerated Prion Disease Pathogenesis in Toll-Like Receptor 4 Signaling-Mutant Mice
Published in Journal of Virology (01-11-2008)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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