Chitosan-based glycerol-plasticized membranes: bactericidal and fibroblast cellular growth properties

Chitosan-based glycerol-plasticized membranes: bactericidal and fibroblast cellular growth properties

Chitosan-based glycerol-plasticized membranes were prepared aiming to develop low-cost and biocompatible material for wound dressing. They were produced by casting/solvent evaporation, and their formation mechanisms were attributed to intra- and inter-hydrogen bonds between materials. The results sh...

Full description

Saved in:
Bibliographic Details
Published in:Polymer bulletin (Berlin, Germany) Vol. 78; no. 8; pp. 4297 - 4312
Main Authors: Caroni, Joiciara Garcia, de Almeida Mattos, Alexia Victoria, Fernandes, Kelly Rossetti, Balogh, Debora Terezia, Renno, Ana Cláudia Muniz, Okura, Mônica Hitomi, Malpass, Ana Claudia Granato, Ferraresi, Cleber, Garcia, Lívia Assis, Sanfelice, Rafaela Cristina, Pavinatto, Adriana
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-08-2021
Springer Nature B.V
Subjects:
Antibiotics
Bacteria
Biocompatibility
Biomedical materials
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Chitosan
Collagen
Complex Fluids and Microfluidics
Contact angle
Ductile-brittle transition
E coli
Fibroblasts
Fourier transforms
Glass transition temperature
Glycerol
Hydrogen bonds
Hydrogen embrittlement
Membranes
Organic Chemistry
Original Paper
Physical Chemistry
Plastic foam
Polymer Sciences
Skin
Soft and Granular Matter
Spectrum analysis
Tissue engineering
Wound healing
Brazil
Cytotoxicity
Casting method
Chitosan
Dynamic mechanical analysis
Tissue repair
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chitosan-based glycerol-plasticized membranes were prepared aiming to develop low-cost and biocompatible material for wound dressing. They were produced by casting/solvent evaporation, and their formation mechanisms were attributed to intra- and inter-hydrogen bonds between materials. The results show that the glycerol acted as plasticizer and changed the proliferation of fibroblast cells on chitosan membranes. A high increase in the contact angle between water and membrane was observed comparing pure chitosan (more hydrophilic) and chitosan-glycerol (more hydrophobic) membranes. The angle values were found to be ~ 40 and ~ 130 degrees for chitosan and chitosan/glycerol 30% (w/w) membranes, respectively. In comparison with pure chitosan, glycerol-mixed membranes showed lower glass transition temperatures and are less brittle when handling. The antibacterial properties of such membranes against Gram-negative ( E. coli ) and Gram-positive ( S. aureus and B. Cereus ) microorganisms were tested, showing efficient growth inhibition. In vitro studies over fibroblast cells using plasticized membranes demonstrated good viability and enhanced cell proliferation in comparison with those composed of pure chitosan. Such results suggest that the as-prepared chitosan-glycerol membrane is a promising material for use as wound dressing in tissue engineering applications.
ISSN:0170-0839
1436-2449
DOI:10.1007/s00289-020-03310-4