Search Results - "Carone, Benjamin R"

High-Resolution Mapping of Chromatin Packaging in Mouse Embryonic Stem Cells and Sperm by Carone, Benjamin R., Hung, Jui-Hung, Hainer, Sarah J., Chou, Min-Te, Carone, Dawn M., Weng, Zhiping, Fazzio, Thomas G., Rando, Oliver J.

“…Mammalian embryonic stem cells (ESCs) and sperm exhibit unusual chromatin packaging that plays important roles in cellular function. Here, we extend a recently…”
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Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals by Sharma, Upasna, Conine, Colin C., Shea, Jeremy M., Boskovic, Ana, Derr, Alan G., Bing, Xin Y., Belleannee, Clemence, Kucukural, Alper, Serra, Ryan W., Sun, Fengyun, Song, Lina, Carone, Benjamin R., Ricci, Emiliano P., Li, Xin Z., Fauquier, Lucas, Moore, Melissa J., Sullivan, Robert, Mello, Craig C., Garber, Manuel, Rando, Oliver J.

“…Several recent studies link parental environments to phenotypes in subsequent generations. In this work, we investigate the mechanism by which paternal diet…”
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Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals by Carone, Benjamin R., Fauquier, Lucas, Habib, Naomi, Shea, Jeremy M., Hart, Caroline E., Li, Ruowang, Bock, Christoph, Li, Chengjian, Gu, Hongcang, Zamore, Phillip D., Meissner, Alexander, Weng, Zhiping, Hofmann, Hans A., Friedman, Nir, Rando, Oliver J.

“…Epigenetic information can be inherited through the mammalian germline and represents a plausible transgenerational carrier of environmental information. To…”
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Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome by Shea, Jeremy M., Serra, Ryan W., Carone, Benjamin R., Shulha, Hennady P., Kucukural, Alper, Ziller, Michael J., Vallaster, Markus P., Gu, Hongcang, Tapper, Andrew R., Gardner, Paul D., Meissner, Alexander, Garber, Manuel, Rando, Oliver J.

“…Paternal diet can impact metabolic phenotypes in offspring, but mechanisms underlying such intergenerational information transfer remain obscure. Here, we…”
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Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF by Hainer, Sarah J, Gu, Weifeng, Carone, Benjamin R, Landry, Benjamin D, Rando, Oliver J, Mello, Craig C, Fazzio, Thomas G

“…Approximately 75% of the human genome is transcribed, the majority of which does not encode protein. However, many noncoding RNAs (ncRNAs) are rapidly degraded…”
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Detecting Fear-Memory-Related Genes from Neuronal scRNA-seq Data by Diverse Distributions and Bhattacharyya Distance by Zhang, Shaoqiang, Xie, Linjuan, Cui, Yaxuan, Carone, Benjamin R., Chen, Yong

“…The detection of differentially expressed genes (DEGs) is one of most important computational challenges in the analysis of single-cell RNA sequencing…”
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Role of Cationic Side Chains in the Antimicrobial Activity of C18G by Kohn, Eric M, Shirley, David J, Arotsky, Lubov, Picciano, Angela M, Ridgway, Zachary, Urban, Michael W, Carone, Benjamin R, Caputo, Gregory A

“…Antimicrobial peptides (AMPs) have been an area of great interest, due to the high selectivity of these molecules toward bacterial targets over host cells and…”
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Correlating Lipid Membrane Permeabilities of Imidazolium Ionic Liquids with their Cytotoxicities on Yeast, Bacterial, and Mammalian Cells by Cook, Kendall, Tarnawsky, Katharine, Swinton, Alana J, Yang, Daniel D, Senetra, Alexandria S, Caputo, Gregory A, Carone, Benjamin R, Vaden, Timothy D

“…Alkyl-imidazolium chloride ionic liquids (ILs) have been broadly studied for biochemical and biomedical technologies. They can permeabilize lipid bilayer…”
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Optimization of Biocompatibility for a Hydrophilic Biological Molecule Encapsulation System by Sanders, Alyssa B, Zangaro, Jacob T, Webber, Nakoa K, Calhoun, Ryan P, Richards, Elizabeth A, Ricci, Samuel L, Work, Hannah M, Yang, Daniel D, Casey, Kaitlyn R, Iovine, Joseph C, Baker, Gabriela, Douglas, Taylor V, Dutko, Sierra B, Fasano, Thomas J, Lofland, Sarah A, Rajan, Ashley A, Vasile, Mihaela A, Carone, Benjamin R, Nucci, Nathaniel V

“…Despite considerable advances in recent years, challenges in delivery and storage of biological drugs persist and may delay or prohibit their clinical…”
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Synergistic interactions of ionic liquids and antimicrobials improve drug efficacy by Yang, Daniel D., Paterna, Nicholas J., Senetra, Alexandria S., Casey, Kaitlyn R., Trieu, Phillip D., Caputo, Gregory A., Vaden, Timothy D., Carone, Benjamin R.

“…Combinations of ionic liquids (ILs) with antimicrobial compounds have been shown to produce synergistic activities in model liposomes. In this study,…”
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Rewriting the Epigenome by Carone, Benjamin R., Rando, Oliver J.

“…The eukaryotic genome is packaged into a highly ordered chromatin structure, with specific domains regulating the transcription patterns of local genes…”
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new class of retroviral and satellite encoded small RNAs emanates from mammalian centromeres by Carone, Dawn M, Longo, Mark S, Ferreri, Gianni C, Hall, Laura, Harris, Melissa, Shook, Nicole, Bulazel, Kira V, Carone, Benjamin R, Obergfell, Craig, O'Neill, Michael J, O'Neill, Rachel J

“…The transcriptional framework of the eukaryotic centromere core has been described in budding yeast and rice, but for most eukaryotes and all vertebrates it…”
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Cationic Molecular Umbrellas as Antibacterial Agents with Remarkable Cell-Type Selectivity by Chen, Ao, Karanastasis, Apostolos, Casey, Kaitlyn R, Necelis, Matthew, Carone, Benjamin R, Caputo, Gregory A, Palermo, Edmund F

“…We synthesized a combinatorial library of dendrons that display a cluster of cationic charges juxtaposed with a hydrophobic alkyl chain, using the so-called…”
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Translating dosage compensation to trisomy 21 by Jiang, Jun, Jing, Yuanchun, Cost, Gregory J., Chiang, Jen-Chieh, Kolpa, Heather J., Cotton, Allison M., Carone, Dawn M., Carone, Benjamin R., Shivak, David A., Guschin, Dmitry Y., Pearl, Jocelynn R., Rebar, Edward J., Byron, Meg, Gregory, Philip D., Brown, Carolyn J., Urnov, Fyodor D., Hall, Lisa L., Lawrence, Jeanne B.

“…Down’s syndrome is a common disorder with enormous medical and social costs, caused by trisomy for chromosome 21. We tested the concept that gene imbalance…”
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Sequence and Dispersity Are Determinants of Photodynamic Antibacterial Activity Exerted by Peptidomimetic Oligo(thiophene)s by Zhou, Zhe, Ergene, Cansu, Lee, Joshua Y, Shirley, David J, Carone, Benjamin R, Caputo, Gregory A, Palermo, Edmund F

“…A library of functionalized oligo­(thiophene)­s with precisely controlled chain length, regioregularity, sequence, and pendant moieties in the side chains was…”
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Lipid bilayer permeabilities and antibiotic effects of tetramethylguanidinium and choline fatty acid ionic liquids by Dutta, Achismita, Burrell, Brandon, Prajapati, Esha, Cottle, Sierra, Maurer, Hailey Y., Urban, Matthew J., Pennock, Samuel R., Muhamed, Arwa M., Harris, Janiyah, Flores, Yesenia, Staman, Lauren, Carone, Benjamin R., Caputo, Gregory A., Vaden, Timothy D.

“…Ionic liquids (ILs) have been studied as potential components in antibiotic formulations based on their abilities to permeabilize and penetrate lipid bilayer,…”
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Genomic imprinting of IGF2 in marsupials is methylation dependent by Lawton, Betty R, Carone, Benjamin R, Obergfell, Craig J, Ferreri, Gianni C, Gondolphi, Christina M, Vandeberg, John L, Imumorin, Ikhide, O'Neill, Rachel J, O'Neill, Michael J

“…Parent-specific methylation of specific CpG residues is critical to imprinting in eutherian mammals, but its importance to imprinting in marsupials and, thus,…”
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NPC1 deficiency impairs cerebellar postnatal development of microglia and climbing fiber refinement in a mouse model of Niemann-Pick disease type C by Boyle, Bridget R, Melli, Sierra E, Altreche, Ruth S, Padron, Zachary M, Yousufzai, Fawad A K, Kim, Sarah, Vasquez, Mariella D, Carone, Dawn M, Carone, Benjamin R, Soto, Ileana

“…Little is known about the effects of NPC1 deficiency in brain development and whether these effects contribute to neurodegeneration in Niemann-Pick disease…”
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NPC1 deficiency impairs cerebellar postnatal development of microglia and climbing fiber refinement in a mouse model of Niemann-Pick Type C disease by Boyle, Bridget R, Melli, Sierra E, Altreche, Ruth S, Padron, Zachary M, Yousufzai, Fawad A K, Kim, Sarah, Vasquez, Mariella D, Carone, Dawn M, Carone, Benjamin R, Soto, Ileana

“…Little is known about the effects of NPC1 deficiency in brain development and if they contribute to neurodegeneration in Niemann-Pick Type C disease. Since…”
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Antimicrobial activity of a porphyrin binding peptide by Shirley, David J, Chrom, Christina L, Richards, Elizabeth A, Carone, Benjamin R, Caputo, Gregory A

“…Amphiphilic alpha-helices are common motifs used in numerous biological systems including membrane channels/pores and antimicrobial peptides (AMPs), and…”
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