Search Results - "Caron, Paul R"

A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants by Adiwijaya, Bambang S, Herrmann, Eva, Hare, Brian, Kieffer, Tara, Lin, Chao, Kwong, Ann D, Garg, Varun, Randle, John C R, Sarrazin, Christoph, Zeuzem, Stefan, Caron, Paul R

“…Variants resistant to compounds specifically targeting HCV are observed in clinical trials. A multi-variant viral dynamic model was developed to quantify the…”
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The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity by Yaffe, Michael B, Rittinger, Katrin, Volinia, Stefano, Caron, Paul R, Aitken, Alastair, Leffers, Henrik, Gamblin, Steven J, Smerdon, Stephen J, Cantley, Lewis C

“…The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. Using phosphoserine-oriented peptide libraries to…”
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X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex by Griffith, James P, Kim, Joseph L, Kim, Eunice E, Sintchak, Michael D, Thomson, John A, Fitzgibbon, Matthew J, Fleming, Mark A, Caron, Paul R, Hsiao, Kathy, Navia, Manuel A

“…The X-ray structure of the ternary complex of a calcineurin A fragment, calcineurin B, FKBP12, and the immunosuppressant drug FK506 (also known as tacrolimus)…”
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Crystal structure of JNK3: a kinase implicated in neuronal apoptosis by Xie, Xiaoling, Gu, Yong, Fox, Ted, Coll, Joyce T, Fleming, Mark A, Markland, William, Caron, Paul R, Wilson, Keith P, Su, Michael S-S

“…Background: The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein (MAP) kinase family, and regulate signal transduction in response…”
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Classifying protein kinase structures guides use of ligand-selectivity profiles to predict inactive conformations: Structure of lck/imatinib complex by Jacobs, Marc D., Caron, Paul R., Hare, Brian J.

“…We report a clustering of public human protein kinase structures based on the conformations of two structural elements, the activation segment and the C‐helix,…”
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Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding by Kim, Joseph L, Morgenstern, Kurt A, Griffith, James P, Dwyer, Maureen D, Thomson, John A, Murcko, Mark A, Lin, Chao, Caron, Paul R

“…Background: Hepatitis C virus (HCV) represents a major health concern as it is responsible for a significant number of hepatitis cases worldwide. Much research…”
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Rapid decrease of wild-type hepatitis C virus on telaprevir treatment by ADIWIJAYA, Bambang S, HARE, Brian, CARON, Paul R, RANDLE, John Cr, NEUMANN, Avidan U, REESINK, Hendrik W, ZEUZEM, Stefan, HERRMANN, Eva

“…Telaprevir (TVR) is a hepatitis C virus (HCV) NS3.4A protease inhibitor that has exhibited antiviral activity in patients with HCV genotype 1 infection. The…”
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Introduction to chemical genomics by Caron, Paul R

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Crystal Structure of p38 Mitogen-activated Protein Kinase by Wilson, Keith P., Fitzgibbon, Matthew J., Caron, Paul R., Griffith, James P., Chen, Wenyong, McCaffrey, Patricia G., Chambers, Stephen P., Su, Michael S.-S.

“…p38 mitogen-activated protein kinase is activated by environmental stress and cytokines and plays a role in transcriptional regulation and inflammatory…”
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CORES:  An Automated Method for Generating Three-Dimensional Models of Protein/Ligand Complexes by Hare, Brian J, Walters, W. Patrick, Caron, Paul R, Bemis, Guy W

“…We describe a new, automated method for building 3D models of small-molecule ligands complexed with proteins. Modeling templates are constructed from…”
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Human TOP3: A Single-Copy Gene Encoding DNA Topoisomerase III by Hanai, Ryo, Caron, Paul R., Wang, James C.

“…A human cDNA encoding a protein homologous to the Escherichia coli DNA topoisomerase I subfamily of enzymes has been identified through cloning and sequencing…”
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Genetic approach to chemical genetics by Caron, Paul R

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The role of DNA topoisomerases in recombination and genome stability: a double-edged sword? by Wang, J C, Caron, P R, Kim, R A

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Molecular Dissection of a Protein SopB Essential for Escherichia coli F Plasmid Partition by Hanai, Ryo, Liu, Ruiping, Benedetti, Piero, Caron, Paul R., Lynch, A. Simon, Wang, James C.

“…Biochemical and genetic experiments were carried out to deduce the structural and functional domains of SopB protein involved in the equipartition of F…”
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Effects of yeast DNA topoisomerase III on telomere structure by Kim, Raymond A., Caron, Paul R., Wang, James C.

“…The yeast TOP3 gene, encoding DNA topoisomerase III, and EST1 gene, encoding a putative telomerase, are shown to be abutted head-to-head on chromosome XII,…”
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A mutational analysis of the active site of human type II inosine 5′-monophosphate dehydrogenase by Futer, Olga, Sintchak, Michael D., Caron, Paul R., Nimmesgern, Elmar, DeCenzo, Maureen T., Livingston, David J., Raybuck, Scott A.

“…The oxidation of IMP to XMP is the rate-limiting step in the de novo synthesis of guanine ribonucleotides. This NAD-dependent reaction is catalyzed by the…”
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Involvement of a cryptic ATPase activity of UvrB and its proteolysis product, UvrB in DNA repair by CARON, P. R, GROSSMAN, L

“…The incision of damaged DNA by the Escherichia coli UvrABC endonuclease requires ATP hydrolysis. Although the deduced sequence of the UvrB protein suggests a…”
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Identification and Characterization of CPP32/Mch2 Homolog 1, a Novel Cysteine Protease Similar to CPP32 by Lippke, J A, Gu, Y, Sarnecki, C, Caron, P R, Su, M S

“…We have identified and characterized a novel cysteine protease named CMH-1 that is a new member of the interleukin 1β converting enzyme (ICE) family of…”
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The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase by Wilson, Keith P., McCaffrey, Patricia G., Hsiao, Kathy, Pazhanisamy, Sam, Galullo, Vincent, Bemis, Guy W., Fitzgibbon, Matthew J., Caron, Paul R., Murcko, Mark A., Su, Michael S.S.

“…Background: The p38 mitogen-activated protein (MAP) kinase regulates signal transduction in response to environmental stress. Pyridinylimidazole compounds are…”
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Potential role of proteolysis in the control of UvrABC incision by CARON, P. R, GROSSMAN, L

“…UvrB is specifically proteolyzed in Escherichia coli cell extracts to UvrB*. UvrB* is capable of interacting with UvrA in an aparently similar manner to the…”
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