Search Results - "Caron, Kathleen M."

Adrenomedullin Induces Cardiac Lymphangiogenesis After Myocardial Infarction and Regulates Cardiac Edema Via Connexin 43 by Trincot, Claire E, Xu, Wenjing, Zhang, Hua, Kulikauskas, Molly R, Caranasos, Thomas G, Jensen, Brian C, Sabine, Amélie, Petrova, Tatiana V, Caron, Kathleen M

“…RATIONALE:Cardiac lymphangiogenesis contributes to the reparative process post-myocardial infarction, but the factors and mechanisms regulating it are not well…”
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Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional remodeling and reelin secretion by Serafin, D. Stephen, Harris, Natalie R., Bálint, László, Douglas, Elizabeth S., Caron, Kathleen M.

“…The adhesion receptor vascular endothelial (VE)-cadherin transduces an array of signals that modulate crucial lymphatic cell behaviors including permeability…”
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RAMP3 determines rapid recycling of atypical chemokine receptor-3 for guided angiogenesis by Mackie, Duncan I., Nielsen, Natalie R., Harris, Matthew, Singh, Smriti, Davis, Reema B., Dy, Danica, Ladds, Graham, Caron, Kathleen M.

“…Receptor-activity–modifying proteins (RAMPs) are single transmembrane-spanning proteins which serve as molecular chaperones and allosteric modulators of…”
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E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration by Hollern, Daniel P., Swiatnicki, Matthew R., Rennhack, Jonathan P., Misek, Sean A., Matson, Brooke C., McAuliff, Andrew, Gallo, Kathleen A., Caron, Kathleen M., Andrechek, Eran R.

“…In prior work we demonstrated that loss of E2F transcription factors inhibits metastasis. Here we address the mechanisms for this phenotype and identify the…”
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VE-Cadherin Is Required for Cardiac Lymphatic Maintenance and Signaling by Harris, Natalie R., Nielsen, Natalie R., Pawlak, John B., Aghajanian, Amir, Rangarajan, Krsna, Serafin, D. Stephen, Farber, Gregory, Dy, Danielle M., Nelson-Maney, Nathan P., Xu, Wenjing, Ratra, Disha, Hurr, Sophia H., Qian, Li, Scallan, Joshua P., Caron, Kathleen M.

“…The adherens protein VE-cadherin (vascular endothelial cadherin) has diverse roles in organ-specific lymphatic vessels. However, its physiological role in…”
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Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling by Pawlak, John B, Bálint, László, Lim, Lillian, Ma, Wanshu, Davis, Reema B, Benyó, Zoltán, Soares, Michael J, Oliver, Guillermo, Kahn, Mark L, Jakus, Zoltán, Caron, Kathleen M

“…Molecular heterogeneity of endothelial cells underlies their highly specialized functions during changing physiological conditions within diverse vascular…”
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Small GTPase Rap1A/B Is Required for Lymphatic Development and Adrenomedullin-Induced Stabilization of Lymphatic Endothelial Junctions by Xu, Wenjing, Wittchen, Erika S, Hoopes, Samantha L, Stefanini, Lucia, Burridge, Keith, Caron, Kathleen M

“…OBJECTIVE—Maintenance of lymphatic permeability is essential for normal lymphatic function during adulthood, but the precise signaling pathways that control…”
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Lymphatic Programing and Specialization in Hybrid Vessels by Pawlak, John B, Caron, Kathleen M

“…Building on a large body of existing blood vascular research, advances in lymphatic research have helped kindle broader investigations into vascular diversity…”
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RASA3 is a critical inhibitor of RAP1-dependent platelet activation by Stefanini, Lucia, Paul, David S, Robledo, Raymond F, Chan, E Ricky, Getz, Todd M, Campbell, Robert A, Kechele, Daniel O, Casari, Caterina, Piatt, Raymond, Caron, Kathleen M, Mackman, Nigel, Weyrich, Andrew S, Parrott, Matthew C, Boulaftali, Yacine, Adams, Mark D, Peters, Luanne L, Bergmeier, Wolfgang

“…The small GTPase RAP1 is critical for platelet activation and thrombus formation. RAP1 activity in platelets is controlled by the GEF CalDAG-GEFI and an…”
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Gap Junction Coupling Is Required for Tumor Cell Migration Through Lymphatic Endothelium by Karpinich, Natalie O, Caron, Kathleen M

“…OBJECTIVE—The lymphatic vasculature is a well-established conduit for metastasis, but the mechanisms by which tumor cells interact with lymphatic endothelial…”
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Functional redundancy between RAP1 isoforms in murine platelet production and function by Stefanini, Lucia, Lee, Robert H., Paul, David S., O'Shaughnessy, Ellen C., Ghalloussi, Dorsaf, Jones, Christopher I., Boulaftali, Yacine, Poe, Kathryn O., Piatt, Raymond, Kechele, Dan O., Caron, Kathleen M., Hahn, Klaus M., Gibbins, Jonathan M., Bergmeier, Wolfgang

“…RAP GTPases, important regulators of cellular adhesion, are abundant signaling molecules in the platelet/megakaryocytic lineage. However, mice lacking the…”
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Decoy Receptor CXCR7 Modulates Adrenomedullin-Mediated Cardiac and Lymphatic Vascular Development by Klein, Klara R., Karpinich, Natalie O., Espenschied, Scott T., Willcockson, Helen H., Dunworth, William P., Hoopes, Samantha L., Kushner, Erich J., Bautch, Victoria L., Caron, Kathleen M.

“…Atypical 7-transmembrane receptors, often called decoy receptors, act promiscuously as molecular sinks to regulate ligand bioavailability and consequently…”
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The expanding repertoire of receptor activity modifying protein (RAMP) function by Klein, Klara R, Matson, Brooke C, Caron, Kathleen M

“…Receptor activity modifying proteins (RAMPs) associate with G-protein-coupled receptors (GPCRs) at the plasma membrane and together bind a variety of peptide…”
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Characterization of Antibodies against Receptor Activity-Modifying Protein 1 (RAMP1): A Cautionary Tale by Hendrikse, Erica R, Rees, Tayla A, Tasma, Zoe, Garelja, Michael L, Siow, Andrew, Harris, Paul W R, Pawlak, John B, Caron, Kathleen M, Blakeney, Elizabeth S, Russo, Andrew F, Sowers, Levi P, Lutz, Thomas A, Le Foll, Christelle, Walker, Christopher S, Hay, Debbie L

“…Calcitonin gene-related peptide (CGRP) is a key component of migraine pathophysiology, yielding effective migraine therapeutics. CGRP receptors contain a core…”
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Characteristics of multi-organ lymphangiectasia resulting from temporal deletion of calcitonin receptor-like receptor in adult mice by Hoopes, Samantha L, Willcockson, Helen H, Caron, Kathleen M

“…Adrenomedullin (AM) and its receptor complexes, calcitonin receptor-like receptor (Calcrl) and receptor activity modifying protein 2/3, are highly expressed in…”
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Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development by Xu, Wenjing, Nelson-Maney, Nathan P, Bálint, László, Kwon, Hyouk-Bum, Davis, Reema B, Dy, Danielle C M, Dunleavey, James M, St Croix, Brad, Caron, Kathleen M

“…Numerous studies have focused on the molecular signaling pathways that govern the development and growth of lymphatics in the hopes of elucidating promising…”
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Extreme Hydrops Fetalis and Cardiovascular Abnormalities in Mice Lacking a Functional Adrenomedullin gene by Caron, Kathleen M., Smithies, Oliver

“…Adrenomedullin, a recently identified potent vasodilator, is expressed widely and has been suggested to have functions ranging from reproduction to blood…”
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Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice by Li, Manyu, Wetzel-Strong, Sarah E, Hua, Xiaoyang, Tilley, Stephen L, Oswald, Erin, Krummel, Matthew F, Caron, Kathleen M

“…Asthma is a chronic inflammatory disease affecting the lung, characterized by breathing difficulty during an attack following exposure to an environmental…”
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Adrenomedullin and endocrine control of immune cells during pregnancy by Matson, Brooke C, Caron, Kathleen M

“…The immunology of pregnancy is complex and incompletely understood. Aberrant immune activity in the decidua and in the placenta is believed to play a role in…”
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Loss of receptor activity-modifying protein 2 in mice causes placental dysfunction and alters PTH1R regulation by Kadmiel, Mahita, Matson, Brooke C, Espenschied, Scott T, Lenhart, Patricia M, Caron, Kathleen M

“…Receptor activity-modifying protein 2 (Ramp2) is a single-pass transmembrane protein that heterodimerizes with several family B G-protein coupled receptors to…”
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