Search Results - "Caron, Huib N."

Cardioprotective interventions for cancer patients receiving anthracyclines by van Dalen, Elvira C, Caron, Huib N, Dickinson, Heather O, Kremer, Leontien Cm

“…Anthracyclines are among the most effective chemotherapeutic agents in the treatment of numerous malignancies. Unfortunately, their use is limited by a…”
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A worldwide collaboration to harmonize guidelines for the long-term follow-up of childhood and young adult cancer survivors: A report from the international late effects of Childhood Cancer Guideline Harmonization Group by Kremer, Leontien C.M., Mulder, Renée L., Oeffinger, Kevin C., Bhatia, Smita, Landier, Wendy, Levitt, Gill, Constine, Louis S., Wallace, W. Hamish, Caron, Huib N., Armenian, Saro H., Skinner, Roderick, Hudson, Melissa M.

“…Childhood and young adult cancer survivors should receive optimum care to reduce the consequences of late effects and improve quality of life. We can…”
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High Risk of Symptomatic Cardiac Events in Childhood Cancer Survivors by DER PAL, Helena J. Van, DALEN, Elvira C. Van, CARON, Huib N, KREMER, Leontien C, DELDEN, Evelien Van, DIJK, Irma W. Van, KOK, Wouter E, GESKUS, Ronald B, SIESWERDA, Elske, OLDENBURGER, Foppe, KONING, Caro C, LEEUWEN, Flora E. Van

“…To evaluate the long-term risk for validated symptomatic cardiac events (CEs) and associated risk factors in childhood cancer survivors (CCSs). We determined…”
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Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features by Kool, Marcel, Koster, Jan, Bunt, Jens, Hasselt, Nancy E, Lakeman, Arjan, van Sluis, Peter, Troost, Dirk, Meeteren, Netteke Schouten-van, Caron, Huib N, Cloos, Jacqueline, Mrsić, Alan, Ylstra, Bauke, Grajkowska, Wieslawa, Hartmann, Wolfgang, Pietsch, Torsten, Ellison, David, Clifford, Steven C, Versteeg, Rogier

“…Medulloblastoma is the most common malignant brain tumor in children. Despite recent improvements in cure rates, prediction of disease outcome remains a major…”
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Pharmacogenomic Prediction of Anthracycline-Induced Cardiotoxicity in Children by VISSCHER, Henk, ROSS, Colin J. D, DER PAL, Helena J. Van, BROWN, Andrew M. K, ROGERS, Paul C, PHILLIPS, Michael S, RIEDER, Michael J, CARLETON, Bruce C, HAYDEN, Michael R, ROD RASSEKH, S, BARHDADI, Amina, DUBE, Marie-Pierre, AL-SALOOS, Hesham, SANDOR, George S, CARON, Huib N, DALEN, Elvira C. Van, KREMER, Leontien C

“…Anthracycline-induced cardiotoxicity (ACT) is a serious adverse drug reaction limiting anthracycline use and causing substantial morbidity and mortality. Our…”
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Equivalence Ratio for Daunorubicin to Doxorubicin in Relation to Late Heart Failure in Survivors of Childhood Cancer by Feijen, Elizabeth A M, Leisenring, Wendy M, Stratton, Kayla L, Ness, Kirsten K, van der Pal, Helena J H, Caron, Huib N, Armstrong, Gregory T, Green, Daniel M, Hudson, Melissa M, Oeffinger, Kevin C, Robison, Leslie L, Stovall, Marilyn, Kremer, Leontien C M, Chow, Eric J

“…Cumulative anthracycline dose is one of the strongest predictors of heart failure (HF) after cancer treatment. However, the differential risk for…”
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Histone deacetylases (HDACs): characterization of the classical HDAC family by de Ruijter, Annemieke J M, van Gennip, Albert H, Caron, Huib N, Kemp, Stephan, van Kuilenburg, André B P

“…Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly influenced by the post-translational modification of histones, the…”
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Medical Assessment of Adverse Health Outcomes in Long-term Survivors of Childhood Cancer by Geenen, Maud M, Cardous-Ubbink, Mathilde C, Kremer, Leontien C. M, van den Bos, Cor, van der Pal, Helena J. H, Heinen, Richard C, Jaspers, Monique W. M, Koning, Caro C. E, Oldenburger, Foppe, Langeveld, Nelia E, Hart, Augustinus A. M, Bakker, Piet J. M, Caron, Huib N, van Leeuwen, Flora E

“…CONTEXT Improved survival of children with cancer has been accompanied by multiple treatment-related complications. However, most studies in survivors of…”
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Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells by Molenaar, Jan J, Ebus, Marli E, Geerts, Dirk, Koster, Jan, Lamers, Fieke, Valentijn, Linda J, Westerhout, Ellen M, Versteeg, Rogier, Caron, Huib N

“…Two genes have a synthetically lethal relationship when the silencing or inhibiting of 1 gene is only lethal in the context of a mutation or activation of the…”
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Enhancer of zeste homologue 2 plays an important role in neuroblastoma cell survival independent of its histone methyltransferase activity by Bate-Eya, Laurel T, Gierman, Hinco J, Ebus, Marli E, Koster, Jan, Caron, Huib N, Versteeg, Rogier, Dolman, M. Emmy M, Molenaar, Jan J

“…Abstract Neuroblastoma is predominantly characterised by chromosomal rearrangements. Next to V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived…”
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Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma by Molenaar, Jan J, Ebus, Marli E, Koster, Jan, van Sluis, Peter, van Noesel, Carel J M, Versteeg, Rogier, Caron, Huib N

“…Genomic aberrations of Cyclin D1 (CCND1), CDK4, and CDK6 in neuroblastoma indicate that dysregulation of the G(1) entry checkpoint is an important cell cycle…”
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DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells by Dolman, M Emmy M, van der Ploeg, Ida, Koster, Jan, Bate-Eya, Laurel Tabe, Versteeg, Rogier, Caron, Huib N, Molenaar, Jan J

“…Tumor cells might resist therapy with ionizing radiation (IR) by non-homologous end-joining (NHEJ) of IR-induced double-strand breaks. One of the key players…”
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Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe by Lamers, Fieke, van der Ploeg, Ida, Schild, Linda, Ebus, Marli E, Koster, Jan, Hansen, Bo R, Koch, Troels, Versteeg, Rogier, Caron, Huib N, Molenaar, Jan J

“…BIRC5 (survivin) is one of the genes located on chromosome arm 17q in the region that is often gained in neuroblastoma. BIRC5 is a protein in the intrinsic…”
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MEK inhibition causes BIM stabilization and increased sensitivity to BCL-2 family member inhibitors in RAS-MAPK-mutated neuroblastoma by Eleveld, Thomas F, Vernooij, Lindy, Schild, Linda, Koopmans, Bianca, Alles, Lindy K, Ebus, Marli E, Dandis, Rana, van Tinteren, Harm, Caron, Huib N, Koster, Jan, van Noesel, Max M, Tytgat, Godelieve A M, Eising, Selma, Versteeg, Rogier, Dolman, M Emmy M, Molenaar, Jan J

“…Mutations affecting the RAS-MAPK pathway occur frequently in relapsed neuroblastoma tumors and are associated with response to MEK inhibition . However, these…”
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A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients by Fardin, Paolo, Barla, Annalisa, Mosci, Sofia, Rosasco, Lorenzo, Verri, Alessandro, Versteeg, Rogier, Caron, Huib N, Molenaar, Jan J, Ora, Ingrid, Eva, Alessandra, Puppo, Maura, Varesio, Luigi

“…Hypoxia is a condition of low oxygen tension occurring in the tumor microenvironment and it is related to poor prognosis in human cancer. To examine the…”
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Risk of Symptomatic Stroke After Radiation Therapy for Childhood Cancer: A Long-Term Follow-Up Cohort Analysis by van Dijk, Irma W.E.M., PhD, van der Pal, Helena J.H., MD, PhD, van Os, Rob M., MSc, Roos, Yvo B.W.E.M., MD, PhD, Sieswerda, Elske, MD, PhD, van Dalen, Elvira C., MD, PhD, Ronckers, Cécile M., PhD, Oldenburger, Foppe, MD, van Leeuwen, Flora E., PhD, Caron, Huib N., MD, PhD, Koning, Caro C.E., MD, PhD, Kremer, Leontien C.M., MD, PhD

“…Purpose Long-term childhood cancer survivors are at high risk of late adverse effects, including stroke. We aimed to determine the cumulative incidence of…”
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High Hospitalization Rates in Survivors of Childhood Cancer: A Longitudinal Follow-Up Study Using Medical Record Linkage by Sieswerda, Elske, Font-Gonzalez, Anna, Reitsma, Johannes B, Dijkgraaf, Marcel G W, Heinen, Richard C, Jaspers, Monique W, van der Pal, Helena J, van Leeuwen, Flora E, Caron, Huib N, Geskus, Ronald B, Kremer, Leontien C

“…Hospitalization rates over time of childhood cancer survivors (CCS) provide insight into the burden of unfavorable health conditions on CCS and health care…”
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Towards personalized therapy in pediatric acute lymphoblastic leukemia: RAS mutations and prednisolone resistance by Ariës, Ingrid M, van den Dungen, Rosanna E, Koudijs, Marco J, Cuppen, Edwin, Voest, Emile, Molenaar, Jan J, Caron, Huib N, Pieters, Rob, den Boer, Monique L

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Evaluation of Late Adverse Events in Long-Term Wilms' Tumor Survivors by van Dijk, Irma W.E.M., M.Sc, Oldenburger, Foppe, M.D, Cardous-Ubbink, Mathilde C., M.Sc, Geenen, Maud M., M.D, Heinen, Richard C., M.Sc, de Kraker, Jan, M.D., Ph.D, van Leeuwen, Flora E., Ph.D, van der Pal, Helena J.H., M.D, Caron, Huib N., M.D., Ph.D, Koning, Caro C.E., M.D., Ph.D, Kremer, Leontien C.M., M.D., Ph.D

“…Purpose To evaluate the prevalence and severity of adverse events (AEs) and treatment-related risk factors in long-term Wilms' tumor (WT) survivors, with…”
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Renal Dysfunction and Elevated Blood Pressure in Long-Term Childhood Cancer Survivors by Knijnenburg, Sebastiaan L, Jaspers, Monique W, van der Pal, Helena J, Schouten-van Meeteren, Antoinette Y, Bouts, Antonia H, Lieverst, Jan A, Bökenkamp, Arend, Koning, Caro C E, Oldenburger, Foppe, Wilde, James C H, van Leeuwen, Flora E, Caron, Huib N, Kremer, Leontien C

“…Little is known about renal function and blood pressure (BP) in long-term childhood cancer survivors. This cross-sectional study evaluated prevalence of these…”
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