Search Results - "Caroli, Antonia"

Investigation of a potential mechanism for the inhibition of SmTGR by Auranofin and its implications for Plasmodium falciparum inhibition by Caroli, Antonia, Simeoni, Silvia, Lepore, Rosalba, Tramontano, Anna, Via, Allegra

“…► We describe the binding site of Auranofin (AF) for SmTGR, an S. mansoni vital enzyme. ► We confirm a molecular mechanism for the SmTGR inhibition by AF. ► We…”
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Combining 3-D Quantitative Structure−Activity Relationship with Ligand Based and Structure Based Alignment Procedures for in Silico Screening of New Hepatitis C Virus NS5B Polymerase Inhibitors by Musmuca, Ira, Caroli, Antonia, Mai, Antonello, Kaushik-Basu, Neerja, Arora, Payal, Ragno, Rino

“…The viral NS5B RNA-dependent RNA-polymerase (RdRp) is one of the best-studied and promising targets for the development of novel therapeutics against hepatitis…”
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Hsp90 Inhibitors, Part 2: Combining Ligand-Based and Structure-Based Approaches for Virtual Screening Application by Caroli, Antonia, Ballante, Flavio, Wickersham, Richard B, Corelli, Federico, Ragno, Rino

“…Hsp90 continues to be an important target for pharmaceutical discovery. In this project, virtual screening (VS) for novel Hsp90 inhibitors was performed using…”
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Hsp90 Inhibitors, Part 1: Definition of 3‑D QSAutogrid/R Models as a Tool for Virtual Screening by Ballante, Flavio, Caroli, Antonia, Wickersham, Richard B, Ragno, Rino

“…The multichaperone heat shock protein (Hsp) 90 complex mediates the maturation and stability of a variety of oncogenic signaling proteins. For this reason,…”
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Identification of the Schistosoma mansoni Molecular Target for the Antimalarial Drug Artemether by Lepore, Rosalba, Simeoni, Silvia, Raimondo, Domenico, Caroli, Antonia, Tramontano, Anna, Via, Allegra

“…Plasmodium falciparum and Schistosoma mansonii are the parasites responsible for most of the malaria and schistosomiasis cases in the world. Notwithstanding…”
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Investigations on the 1-(2-Biphenyl)piperazine Motif: Identification of New Potent and Selective Ligands for the Serotonin 7 (5-HT 7 ) Receptor with Agonist or Antagonist Action in Vitro or ex Vivo by Lacivita, Enza, Patarnello, Daniela, Stroth, Nikolas, Caroli, Antonia, Niso, Mauro, Contino, Marialessandra, De Giorgio, Paola, Di Pilato, Pantaleo, Colabufo, Nicola A., Berardi, Francesco, Perrone, Roberto, Svenningsson, Per, Hedlund, Peter B., Leopoldo, Marcello

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Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo by Lacivita, Enza, Patarnello, Daniela, Stroth, Nikolas, Caroli, Antonia, Niso, Mauro, Contino, Marialessandra, De Giorgio, Paola, Di Pilato, Pantaleo, Colabufo, Nicola A, Berardi, Francesco, Perrone, Roberto, Svenningsson, Per, Hedlund, Peter B, Leopoldo, Marcello

“…Here we report the design, synthesis, and 5-HT(7) receptor affinity of a set of 1-(3-biphenyl)- and 1-(2-biphenyl)piperazines. The effect on 5-HT(7) affinity…”
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Small-Molecule Interferon Inducers. Toward the Comprehension of the Molecular Determinants through Ligand-Based Approaches by Musmuca, Ira, Simeoni, Silvia, Caroli, Antonia, Ragno, Rino

“…Hepatitis C is becoming an increasingly common cause of mortality especially in the HIV-coinfected group. Due to the efficacy of interferon (IFN) based therapy…”
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CYP19 (aromatase): Exploring the scaffold flexibility for novel selective inhibitors by Castellano, Sabrina, Stefancich, Giorgio, Ragno, Rino, Schewe, Katarzyna, Santoriello, Marisabella, Caroli, Antonia, Hartmann, Rolf W., Sbardella, Gianluca

“…Several derivatives out of a series of antifungal agents exhibited a good inhibitory potency against aromatase as well as a fairly good selectivity toward…”
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Investigations on the 1-(2-Biphenyl)piperazine Motif: Identification of New Potent and Selective Ligands for the Serotonin7 (5-HT7) Receptor with Agonist or Antagonist Action in Vitro or ex Vivo by Lacivita, Enza, Patarnello, Daniela, Stroth, Nikolas, Caroli, Antonia, Niso, Mauro, Contino, Marialessandra, De Giorgio, Paola, Di Pilato, Pantaleo, Colabufo, Nicola A, Berardi, Francesco, Perrone, Roberto, Svenningsson, Per, Hedlund, Peter B, Leopoldo, Marcello

“…Here we report the design, synthesis, and 5-HT7 receptor affinity of a set of 1-(3-biphenyl)- and 1-(2-biphenyl)piperazines. The effect on 5-HT7 affinity of…”
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