Search Results - "Carofiglio, Fabrizia"
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Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice
Published in Nucleic acids research (18-03-2021)“…Abstract In most taxa, halving of chromosome numbers during meiosis requires that homologous chromosomes (homologues) pair and form crossovers. Crossovers…”
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2
Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma
Published in eLife (30-07-2021)“…The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a…”
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Super-resolution imaging of RAD51 and DMC1 in DNA repair foci reveals dynamic distribution patterns in meiotic prophase
Published in PLoS genetics (05-06-2020)“…The recombinase RAD51, and its meiosis-specific paralog DMC1 localize at DNA double-strand break (DSB) sites in meiotic prophase. While both proteins are…”
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Repair of exogenous DNA double-strand breaks promotes chromosome synapsis in SPO11-mutant mouse meiocytes, and is altered in the absence of HORMAD1
Published in DNA repair (01-03-2018)“…In mouse spermatocytes and oocytes: •Damage-induced DSBs relocalise to the axial and lateral elements of the SC•Damage-induced DSBs recruit the…”
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SPO11-independent DNA repair foci and their role in meiotic silencing
Published in PLoS genetics (01-06-2013)“…In mammalian meiotic prophase, the initial steps in repair of SPO11-induced DNA double-strand breaks (DSBs) are required to obtain stable homologous chromosome…”
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6
Live cell analyses of synaptonemal complex dynamics and chromosome movements in cultured mouse testis tubules and embryonic ovaries
Published in Chromosoma (01-09-2018)“…During mammalian meiotic prophase, homologous chromosomes connect through the formation of the synaptonemal complex (SC). SYCP3 is a component of the lateral…”
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SPO11-Independent DNA Repair Foci and Their Role in Meiotic Silencing: e1003538
Published in PLoS genetics (01-06-2013)“…In mammalian meiotic prophase, the initial steps in repair of SPO11-induced DNA double-strand breaks (DSBs) are required to obtain stable homologous chromosome…”
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