Search Results - "Caro, José F."

Serum immunoreactive-leptin concentrations in normal-weight and obese humans by Considine, R.V, Sinha, M.K, Heiman, M.L, Kriauciunas, A, Stephens, T.W, Nyce, M.R, Ohannesian, J.P, Marco, C.C, McKee, L.J, Bauer, T.L

“…Background. Leptin, the product of the ob gene, is a hormone secreted by adipocytes. Animals with mutations in the ob gene are obese and lose weight when given…”
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Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance by Caro, J F, Kolaczynski, J W, Nyce, M R, Ohannesian, J P, Opentanova, I, Goldman, W H, Lynn, R B, Zhang, P L, Sinha, M K, Considine, R V

“…A receptor for leptin has been cloned from the choroid plexus, the site of cerebrospinal-fluid (CSF) production and the location of the…”
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Leptin : The tale of an obesity gene by CARO, J. F, SINHA, M. K, KOLACZYNSKI, J. W, PEI LI ZHANG, CONSIDINE, R. V

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Acute and chronic effect of insulin on leptin production in humans : Studies in vivo and in vitro by KOLACZYNSKI, J. W, NYCE, M. R, CONSIDINE, R. V, BODEN, G, NOLAN, J. J, HENRY, R, MUDALIAR, S. R, OLEFSKY, J, CARO, J. F

“…This study was undertaken to investigate the changes in obesity (OB) gene expression and production of leptin in response to insulin in vitro and in vivo under…”
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Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients by Sharma, Kumar, Considine, Robert V., Michael, Beckie, Dunn, Stephen R., Weisberg, Lawrence S., Kurnik, Brenda R.C., Kurnik, Peter B., O'Connor, John, Sinha, Madhur, Caro, José F.

“…Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients. Leptin, the gene product of the ob gene, is important in the control of…”
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IGF-I-stimulated glucose transport in human skeletal muscle and IGF-I resistance in obesity and NIDDM by DOHM, G. L, ELTON, C. W, RAJU, M. S, MOONEY, N. D, DIMARCHI, R, PORIES, W. J, FLICKINGER, E. G, ATKINSON, A. M, CARO, J. F

“…Based on the observation that insulinlike growth factor I (IGF-I) can stimulate glucose utilization in nondiabetic subjects and that the action of the IGF-I…”
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Weight loss in severely obese subjects prevents the progression of impaired glucose tolerance to type II diabetes. A longitudinal interventional study by S D Long, K O'Brien, K G MacDonald, Jr, N Leggett-Frazier, M S Swanson, W J Pories, J F Caro

“…Weight loss in severely obese subjects prevents the progression of impaired glucose tolerance to type II diabetes. A longitudinal interventional study. S D…”
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Effect of troglitazone on leptin production : Studies in vitro and in human subjects by NOLAN, J. J, OLEFSKY, J. M, NYCE, M. R, CONSIDINE, R. V, CARO, J. F

“…Leptin, the product of the ob gene, is a hormone secreted by adipocytes. Animals with mutations in the ob gene are obese and lose weight when given leptin, but…”
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Identification of Novel Genes Differentially Expressed in Omental Fat of Obese Subjects and Obese Type 2 Diabetic Patients by COROMINOLA, Helena, CONNER, Laura J, BEAVERS, Lisa S, GADSKI, Robert A, JOHNSON, Dwayne, CARO, Jose F, RAFAELOFF-PHAIL, Ronit

“…Identification of Novel Genes Differentially Expressed in Omental Fat of Obese Subjects and Obese Type 2 Diabetic Patients Helena Corominola 1 , Laura J…”
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A solution might be within people with diabetes themselves by Caro, Jose F, Fisher, Edwin B

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Adipose tissue glucose transporters in NIDDM : decreased levels of muscle/fat isoform by SINHA, M. K, RAINERI-MALDONADO, C, BUCHANAN, C, PORIES, W. J, CARTER-SU, C, PILCH, P. F, CARO, J. F

“…We investigated the mechanism of peripheral insulin resistance in the adipose tissue of obese and non-insulin-dependent diabetes mellitus (NIDDM) patients at…”
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Cellular alterations in liver, skeletal muscle, and adipose tissue responsible for insulin resistance in obesity and type II diabetes by Caro, J F, Dohm, L G, Pories, W J, Sinha, M K

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Serum leptin in children with obesity: relationship to gender and development by Hassink, S.G. (Alfred I duPont Institute, Wilmington, DE.), Sheslow, D.V, de Lancey, E, Opentanova, I, Considine, R.V, Caro, J.F

“…Background. The identification of the ob gene and its adipocyte-specific protein leptin has provided the first physiologic links to the regulatory system…”
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Immunolocalization of glucose transporter GLUT4 within human skeletal muscle by FRIEDMAN, J. E, DUDEK, R. W, WHITEHEAD, D. S, DOWNES, D. L, FRISELL, W. R, CARO, J. F, DOHM, G. L

“…To investigate the cellular and subcellular distribution of glucose transporters in skeletal muscle, the glucose transporter isoform GLUT4 was localized in…”
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Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance by Hotamisligil, G S, Arner, P, Caro, J F, Atkinson, R L, Spiegelman, B M

“…Obesity is frequently associated with insulin resistance and abnormal glucose homeostasis. Recent studies in animal models have indicated that TNF-alpha plays…”
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Mechanism of IGF-I-stimulated glucose transport in human adipocytes: demonstration of specific IGF-I receptors not involved in stimulation of glucose transport by SINHA, M. K, BUCHANAN, C, LEGGETT, N, MARTIN, L, KHAZANIE, P. G, DIMARCHI, R, PORIES, W. J, CARO, J. F

“…We demonstrate the presence of specific insulinlike growth factor I (IGF-I) receptors in human adipocytes. Competition studies with 125I-labeled IGF-I and…”
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Responses of leptin to short-term fasting and refeeding in humans : A link with ketogenesis but not ketones themselves by KOLACZYNSKI, J. W, CONSIDINE, R. V, OHANNESIAN, J, MARCO, C, OPENTANOVA, I, NYCE, M. R, MYINT, M, CARO, J. F

“…We investigated the response of leptin to short-term fasting and refeeding in humans. A mild decline in subcutaneous adipocyte ob gene mRNA and a marked fall…”
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Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects by Sinha, M K, Ohannesian, J P, Heiman, M L, Kriauciunas, A, Stephens, T W, Magosin, S, Marco, C, Caro, J F

“…We studied 24-h profiles of circulating leptin levels using a sensitive and specific RIA in lean controls and obese subjects with or without…”
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Surgical treatment of obesity and its effect on diabetes: 10-y follow-up by Pories, WJ, MacDonald, KG, Morgan, EJ, Sinha, MK, Dohm, GL, Swanson, MS, Barakat, HA, Khazanie, PG, Leggett-Frazier, N, Long, SD, O'Brien, Kevin F, Caro, Jose F

“…Since 1980 we have performed the identical Greenville gastric bypass (GGB) procedure on 479 morbidly obese patients with an acceptable morbidity and a…”
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Leptin Is Normal in PCOS, An Editorial about Three“ Negative” Papers by Caro, Jose F

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