Search Results - "Caro, Andres A."

Editorial: Oxidative and Nitrosative Effects on the Biochemistry of Photosynthetic Algae and Plants Facing Global Change Conditions by Puntarulo, Susana, Caro, Andres A, Malanga, Gabriela

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Oxidative stress, toxicology, and pharmacology of CYP2E1 by CARO, Andres A, CEDERBAUM, Arthur I

“…This review describes some of the biochemical and toxicological properties of CYP2E1, especially as it relates to alcohol metabolism and toxicity and the…”
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Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity by Caro, Andres A., Cederbaum, Arthur I.

“…Phospholipases A2 (PLA2) comprise a set of extracellular and intracellular enzymes that catalyze the hydrolysis of the sn-2 fatty acyl bond of phospholipids to…”
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Antioxidant and pro-oxidant mechanisms of (+) catechin in microsomal CYP2E1-dependent oxidative stress by Caro, Andres A., Davis, Alanna, Fobare, Sydney, Horan, Nicholas, Ryan, Cameron, Schwab, Cara

“…The objectives of this work were to evaluate the effects of catechin on cytochrome P450 2E1 (CYP2E1)-dependent oxidative stress. Microsomes co-expressing human…”
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Role of phosphatidylinositol 3-kinase/AKT as a survival pathway against CYP2E1-dependent toxicity by Caro, Andres A, Cederbaum, Arthur I

“…The objective of this work was to evaluate the possible role of PI3-kinase/AKT as a survival pathway against CYP2E1-dependent toxicity. E47 cells (HepG2 cells…”
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Iron overload prevents oxidative damage to rat brain after chlorpromazine administration by Piloni, Natacha E., Caro, Andres A., Puntarulo, Susana

“…The hypothesis tested is that Fe administration leads to a response in rat brain modulating the effects of later oxidative challenges such as chlorpromazine…”
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Role of Phospholipase A2 Activation and Calcium in CYP2E1-dependent Toxicity in HepG2 Cells by Caro, Andres A., Cederbaum, Arthur I.

“…Previous studies suggested a role for calcium in CYP2E1-dependent toxicity. The possible role of phospholipase A2 (PLA2) activation in this toxicity was…”
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Effect of garlic-derived organosulfur compounds on mitochondrial function and integrity in isolated mouse liver mitochondria by Caro, Andres A., Adlong, Luke W., Crocker, Samuel J., Gardner, Michael W., Luikart, Emily F., Gron, Liz U.

“…► The direct effect of DAS and DADS on mitochondria was evaluated. ► DADS (not DAS) induced mitochondrial oxidative stress, swelling and depolarization. ►…”
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Role of Calcium and Calcium-activated Proteases in CYP2E1-dependent Toxicity in HEPG2 Cells by Caro, Andres A., Cederbaum, Arthur I.

“…The objective of this work was to investigate whether CYP2E1- and oxidative stress-dependent toxicity in HepG2 cells is mediated by an increase of cytosolic…”
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Increased oxidative stress and cytotoxicity by hydrogen sulfide in HepG2 cells overexpressing cytochrome P450 2E1 by Caro, Andres A., Thompson, Sarah, Tackett, Jonathan

“…The main objectives of this work were to evaluate the effects of hydrogen sulfide on oxidative stress and cytotoxicity parameters in HepG2 cells and to assess…”
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1,3-Butadiene-Induced Mitochondrial Dysfunction is Correlated with Mitochondrial CYP2E1 Activity in Collaborative Cross Mice by Hartman, Jessica H, Miller, Grover P, Caro, Andres A, Byrum, Stephanie D, Orr, Lisa M, Mackintosh, Samuel G, Tackett, Alan J, MacMillan-Crow, Lee Ann, Hallberg, Lance M, Ameredes, Bill T, Boysen, Gunnar

“…Abstract Cytochrome P450 2E1 (CYP2E1) metabolizes low molecular weight hydrophobic compounds, including 1,3-butadiene, which is converted by CYP2E1 to…”
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Prooxidant and antioxidant properties of salicylaldehyde isonicotinoyl hydrazone iron chelators in HepG2 cells by Caro, Andres A., Commissariat, Ava, Dunn, Caroline, Kim, Hyunjoo, García, Salvador Lorente, Smith, Allen, Strang, Harrison, Stuppy, Jake, Desrochers, Linda P., Goodwin, Thomas E.

“…Salicylaldehyde isonicotinoyl hydrazone (SIH) is an iron chelator of the aroylhydrazone class that displays antioxidant or prooxidant effects in different…”
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Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates by Hartman, Jessica H, Martin, H. Cass, Caro, Andres A, Pearce, Amy R, Miller, Grover P

“…Graphical abstract…”
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N-Acetylcysteine Inhibits the Up-Regulation of Mitochondrial Biogenesis Genes in Livers From Rats Fed Ethanol Chronically by Caro, Andres A., Bell, Matthew, Ejiofor, Shannon, Zurcher, Grant, Petersen, Dennis R., Ronis, Martin J. J.

“…Background Chronic ethanol (EtOH) administration to experimental animals induces hepatic oxidative stress and up‐regulates mitochondrial biogenesis. The…”
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Increased stability of mitochondrial CYP2E1 against degradation compared to microsomal CYP2E1 by Hartman, Jessica H., Caro, Andres A., Ronis, Martin J., Miller, Grover P.

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Antioxidant properties of S-adenosyl-L-methionine in Fe(2+)-initiated oxidations by Caro, Andres A, Cederbaum, Arthur I

“…S-Adenosylmethionine (SAM) is protective against a variety of toxic agents that promote oxidative stress. One mechanism for this protective effect of SAM is…”
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Role of intracellular calcium and phospholipase A2 in arachidonic acid-induced toxicity in liver cells overexpressing CYP2E1 by Caro, Andres A., Cederbaum, Arthur I.

“…Liver cells (HepG2 and primary hepatocytes) overexpressing CYP2E1 and exposed to arachidonic acid (AA) were previously shown to lose viability together with…”
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Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl- l-methionine by Caro, Andres A., Cederbaum, Arthur I.

“…The objective of this work was to evaluate the possible in vitro interactions of S-adenosyl- l-methionine (SAM) and its metabolites S-(5′-Adenosyl)-…”
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S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injury by Dey, Aparajita, Caro, Andres A, Cederbaum, Arthur I

“…Pyrazole treatment to induce cytochrome P-450 2E1 (CYP2E1) was recently shown to cause liver injury in ob/ob mice but not in lean mice. The present study…”
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CYP2E1 overexpression inhibits microsomal Ca2+ -ATPase activity in HepG2 cells by Caro, Andres A, Evans, Kerry L, Cederbaum, Arthur I

“…Abstract Cytochrome P450 2E1 (CYP2E1) is a microsomal enzyme that generates reactive oxygen species during its catalytic cycle. We previously found an…”
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