Post-exercise changes in myostatin and actRIIB expression in obese insulin-resistant rats

► We evaluated the expression of MSTN and ActRIIB mRNA in different tissues in rats. ► The expression of MSTN and ActRIIB mRNA differed among the three different tissues. ► The MSTN in mesenteric fat tissue was higher in sedentary high-fat diet fed rats. ► In BAT, exercised rats had increased expres...

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Published in:	Molecular and cellular endocrinology Vol. 339; no. 1-2; pp. 159 - 164
Main Authors:	Bueno, P.G., Bassi, D., Contrera, D.G., Carnielli, H.M., Silva, R.N., Nonaka, K.O., Selistre-de-Araújo, H.S., Leal, A.M.O.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 06-06-2011
Subjects:	Activin Receptors, Type II - genetics Activin Receptors, Type II - metabolism adipose tissue Adipose Tissue, Brown - metabolism Adipose tissues Adiposity Animals Area Under Curve Body Weight Dietary Fats EHF Endocrinology energy Epididymis - pathology Exercise Gene Expression Glucose Tolerance Test Homeostasis Insulin Resistance Intra-Abdominal Fat - metabolism Intra-Abdominal Fat - pathology Male Mesenteric Arteries - pathology messenger RNA Muscle, Skeletal - metabolism Muscles Myostatin Myostatin - genetics Myostatin - metabolism Obesity Obesity - metabolism Physical Conditioning, Animal Rats Rats, Wistar SHF skeletal muscle swimming Obesity Exercise MSTN BAT TGFβ Myostatin ALK5 GAPDH GDF8 ActRIIB
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Summary:	► We evaluated the expression of MSTN and ActRIIB mRNA in different tissues in rats. ► The expression of MSTN and ActRIIB mRNA differed among the three different tissues. ► The MSTN in mesenteric fat tissue was higher in sedentary high-fat diet fed rats. ► In BAT, exercised rats had increased expression of MSTN mRNA. ► In conclusion, we suggest the participation of MSTN in energy homeostasis. We evaluated the expression of MSTN and ActRIIB mRNA in muscle and adipose tissue in diet-induced obesity and insulin resistance in rats subjected to exercise. There was no difference in the expression of MSTN between exercised and sedentary high-fat fed rats in muscle after swimming training. The expression of ActRIIB mRNA in muscle was not significantly different among the groups. In BAT, MSTN mRNA expression was higher in exercised high-fat fed group (EHF) compared with sedentary high-fat fed group (SHF). ActRIIB mRNA expression in BAT was higher in EHF compared with SHF. In mesenteric fat, MSTN mRNA was lower in EHF compared with SHF and ActRIIB mRNA was lower in EHF compared with SHF. In conclusion, the results demonstrate that the expression of MSTN and ActRIIB mRNA changes in both adipose tissue and skeletal muscle in diet-induced obese and exercised rats and suggest the participation of MSTN in energy homeostasis.
Bibliography:	http://dx.doi.org/10.1016/j.mce.2011.04.006 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0303-7207 1872-8057
DOI:	10.1016/j.mce.2011.04.006