Search Results - "Carney, Stephen V."
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Current Approaches for Glioma Gene Therapy and Virotherapy
Published in Frontiers in molecular neuroscience (11-03-2021)“…Glioblastoma (GBM) is the most common and aggressive primary brain tumor in the adult population and it carries a dismal prognosis. Inefficient drug delivery…”
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Journal Article -
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Targeting Neuroinflammation in Brain Cancer: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical Developments
Published in Frontiers in pharmacology (18-05-2021)“…Gliomas are one of the most lethal types of cancers accounting for ∼80% of all central nervous system (CNS) primary malignancies. Among gliomas, glioblastomas…”
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Journal Article -
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Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice
Published in The Journal of clinical investigation (15-02-2021)“…Mutant isocitrate dehydrogenase 1 (IDH1-R132H; mIDH1) is a hallmark of adult gliomas. Lower grade mIDH1 gliomas are classified into 2 molecular subgroups:…”
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Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance
Published in Clinical cancer research (01-05-2023)“…Mutant isocitrate dehydrogenase 1 (mIDH1) alters the epigenetic regulation of chromatin, leading to a hypermethylation phenotype in adult glioma. This work…”
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Journal Article -
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Epigenetic Reprogramming in Mutant IDH1 Glioma Influences Radioresistance and Neural Lineage Differentiation
Published 01-01-2023“…Traditionally, brain tumors were classified based on clinical attributes like anatomical location, patient’s age, and morphologic features. The incorporation…”
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Dissertation