Search Results - "Carney, Patrick R."

Indole-3-Carbinol Induces Tumor Cell Death: Function Follows Form by Megna, Bryant W., BS, Carney, Patrick R., BS, Nukaya, Manabu, PhD, Geiger, Pete, BS, Kennedy, Gregory D., MD, PhD

“…Abstract Background Even with colonoscopy screening and preventive measures becoming more commonplace, colorectal cancer (CRC) remains the third leading cause…”
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The aryl hydrocarbon receptor as an antitumor target of synthetic curcuminoids in colorectal cancer by Megna, Bryant W., BS, Carney, Patrick R., BS, Depke, Mitchell G, Nukaya, Manabu, PhD, McNally, James, BS, Larson, Lesley, PhD, Rosengren, Rhonda J., PhD, Kennedy, Gregory D., MD, PhD

“…Abstract Background Curcumin has proven to be a potent antitumor agent in both preclinical and clinical models of colorectal cancer (CRC). It has also been…”
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Familial isolated pituitary adenoma is independent of Ahr genotype in a novel mouse model of disease by Shen, Anna L., Moran, Susan M., Glover, Edward N., Lin, Bernice C., Carney, Patrick R., Bradfield, Christopher A.

“…Human familial isolated pituitary adenoma (FIPA) has been linked to germline heterozygous mutations in the gene encoding the aryl hydrocarbon…”
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The aryl hydrocarbon receptor as a model PAS sensor by Vazquez-Rivera, Emmanuel, Rojas, Brenda L., Parrott, Jessica C., Shen, Anna L., Xing, Yongna, Carney, Patrick R., Bradfield, Christopher A.

“…[Display omitted] Proteins containing PER-ARNT-SIM (PAS) domains are commonly associated with environmental adaptation in a variety of organisms. The PAS…”
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Enhanced sensitivity of an Ah-receptor system in yeast through condition modification and use of mammalian modifiers by Vazquez-Rivera, Emmanuel, Rojas, Brenda L., Carney, Patrick R., Marrero-Valentin, Jose L., Bradfield, Christopher A.

“…Proteins, such as the Ah receptor (AHR), hold potential as sensors to detect ligands in environmental and biological samples, and may also serve as tools to…”
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Intestinal inflammation and the diet: Is food friend or foe? by Megna, Bryant W, Carney, Patrick R, Kennedy, Gregory D

“…Inflammatory bowel disease (IBD) is a chronic intestinal illness of autoimmune origin affecting millions across the globe. The most common subtypes include…”
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Introducing the American Journal of Surgery Virtual Research Mentor: A primer for aspiring surgeon-scientists by Carney, Patrick R., Ma, Meixi, Theiss, Lauren M., Chidi, Alexis P., Carney, Patrick R., Chidi, Alexis P., Ma, Meixi, Theiss, Lauren M.

“…[...]academic surgery is now defined more by the diversity of those who enter and their interests than ever before.11 Benchmarking studies of leaders in…”
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The Aryl Hydrocarbon Receptor is a Repressor of Inflammation-associated Colorectal Tumorigenesis in Mouse by Díaz-Díaz, Carol J, Ronnekleiv-Kelly, Sean M, Nukaya, Manabu, Geiger, Peter G, Balbo, Silvia, Dator, Romel, Megna, Bryant W, Carney, Patrick R, Bradfield, Christopher A, Kennedy, Gregory D

“…OBJECTIVE:To determine the role of the aryl hydrocarbon receptor (AHR) in colitis-associated colorectal tumorigenesis. BACKGROUND:Colorectal cancer (CRC) is…”
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Admission Thromboelastography at the Intersection of Traumatic Coagulopathy and Inflammation: A Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) Study Subanalysis by Savage, Stephanie A, Zarzaur, Ben L, Fox, Erin E, Wade, Charles E, Carney, Patrick R, Do, Trieu V, Holcomb, John B

“…Acute traumatic coagulopathy (ATC) has many phenotypes and varying morbidity and mortality. The MA-R ratio, calculated from the admission thromboelastogram,…”
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Aryl hydrocarbon receptor-dependent apoptotic cell death induced by the flavonoid chrysin in human colorectal cancer cells by Ronnekleiv-Kelly, Sean M, Nukaya, Manabu, Díaz-Díaz, Carol J, Megna, Bryant W, Carney, Patrick R, Geiger, Peter G, Kennedy, Gregory D

“…Highlights • The treatment of flavonoid chrysin showed a chemopreventive effect in human colorectal cancer cells via the apoptosis pathway. • Up-regulation and…”
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Generation of an Allelic Series at the Ahr Locus Using an Edited Recombinant Approach by Wilson, Rachel H, Carney, Patrick R, Glover, Edward, Parrott, Jessica C, Rojas, Brenda L, Moran, Susan M, Yee, Jeremiah S, Nukaya, Manabu, Goetz, Nicholas A, Rubinstein, Clifford D, Krentz, Kathy J, Xing, Yongna, Bradfield, Christopher A

“…Abstract The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor and a member of the PER-ARNT-SIM (PAS) superfamily of environmental…”
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Transcriptional differences between smokers and non-smokers and variance by obesity as a risk factor for human sensitivity to environmental exposures by Nikodemova, Maria, Yee, Jeremiah, Carney, Patrick R., Bradfield, Christopher A., Malecki, Kristen MC

“…Obesity has been shown to alter response to air pollution and smoking but underlying biological mechanisms are largely unknown and few studies have explored…”
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Extraction Free RT-PCR Surveillance Testing and Reporting for SARS-CoV-2 by Carney, Patrick, Duellman, Tyler, Chan, Jia-Yi, Wells, Lauren, Tessmer, Michael, Frater-Rubsam, Leah, Zeller, Molly, Field, Mark, Speers, James, Tyrrell, Kelly, Thompson, Luke, Bondurant, Michael, Morin, Tami, Dagnon, Tamra, Goff, Brian, Runde, Carissa, Splinter-Bondurant, Sandra, Konsitzke, Charles, Kelly, Patrick, Bradfield, Christopher, Hyman, Joshua

“…The COVID-19 pandemic necessitated sensitive, fast and inexpensive testing for the virus on university campuses across the nation in 2020 prior to the…”
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The impact of transfusion kinetics on the inflammatory response following major injury by Carney, Patrick R., Zarzaur, Ben L., Holcomb, John B., Fox, Erin E., Wade, Charles E., Savage, Stephanie A.

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Genetic Modifiers of Ahr Signaling: Characterization of Candidate Modifiers and Response by Carney, Patrick R

“…The aryl hydrocarbon receptor (AHR) is an environmentally responsive transcription factor that drives differential gene expression upon binding to a variety of…”
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The aryl hydrocarbon receptor mediates the chemopreventive effect of indole-3-carbinol in an inflammation-associated colorectal tumorigenesis model by Díaz-Díaz, Carol J., Ronnekleiv-Kelly, Sean M., Nukaya, Manabu, Geiger, Peter G., Hecht, Stephen S., Balbo, Silvia, Megna, Bryant W., Carney, Patrick R., Bradfield, Christopher A., Kennedy, Gregory D.

“…The deficiency of AHR led to an increase in the susceptibility to colitis-associated colorectal tumorigenesis in mice. In contrast, the activation of AHR by…”
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Intestinal inflammation and the diet:Is food friend or foe? by Bryant W Megna Patrick R Carney Gregory D Kennedy

“…Inflammatory bowel disease(IBD) is a chronic intestinal illness of autoimmune origin affecting millions across the globe. The most common subtypes include…”
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