Calibration transfer from powder mixtures to intact tablets: A new use in pharmaceutical analysis for a known tool

Calibration transfer from powder mixtures to intact tablets: A new use in pharmaceutical analysis for a known tool

Calibration transfer is commonly used for spectra obtained in different spectrometers or other conditions. This paper proposed the use of calibration transfer between spectra recorded for the same samples in different physical forms. A new method was developed for the direct determination of nevirap...

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Bibliographic Details
Published in:Talanta (Oxford) Vol. 147; pp. 351 - 357
Main Authors: Pereira, Leandro S.A., Carneiro, Maíra F., Botelho, Bruno G., Sena, Marcelo M.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 15-01-2016
Subjects:
Calibration
Calibration transfer
Double window piecewise direct standardization
Intact tablets
Multivariate Analysis
Near-infrared spectroscopy
Nevirapine
Nevirapine - analysis
Nevirapine - chemistry
Pharmaceutical quality control
Powders
Spectroscopy, Near-Infrared - methods
Tablets
Calibration transfer
Pharmaceutical quality control
Intact tablets
Nevirapine
Double window piecewise direct standardization
Near-infrared spectroscopy
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Summary:Calibration transfer is commonly used for spectra obtained in different spectrometers or other conditions. This paper proposed the use of calibration transfer between spectra recorded for the same samples in different physical forms. A new method was developed for the direct determination of nevirapine in solid pharmaceutical formulations based on diffuse reflectance near infrared spectroscopy (NIRS) and partial least squares (PLS). This method was developed with 50 powder mixtures and then, successfully extended to the quantification in intact tablets by using calibration transfer with double window piecewise direct standardization (DWPDS). This chemometric strategy provided good results with a small number of tablet transfer samples, only seven, prepared out of the narrow range of active principle ingredients (API) content around the nominal value of the formulation (100%). The method was fully validated in the working range of 83.0–113.9% of nevirapine and the use of DWPDS allowed to significantly decreasing the root mean square error of prediction (RMSEP) from 4.8% (tablets predicted by a model built with only powder samples) to 2.6%. The range of relative errors decreased from −5.1/8.7% to −4.6/3.3%. Considering that the amount of raw materials demanded for preparing tablets is up to ten times higher than for powder mixtures, this type of application is of particular interest in pharmaceutical analysis. In the context of process analytical technology (PAT), the use of the same multivariate model in different steps of the production is very advantageous, saving time and labor. [Display omitted] •Calibration transfer was applied to samples in different physical forms.•Reduction in cost of the method for tablets due to calibration transfer.•A full multivariate validation of the NIR method was performed.•The same method can be used in two steps of the production quality control.•This method is applicable in real time analysis, as suggested by PAT concept.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0039-9140
1873-3573
DOI:10.1016/j.talanta.2015.10.006