Antigenotoxicity protection of Carapa guianensis oil against mitomycin C and cyclophosphamide in mouse bone marrow

The aim of this study was to evaluate the possible protective of C. guianensis oil against MMC and CP, which are direct- and indirect-acting chemical mutagens, using the micronucleus test. Three experiments were performed. First the C. guianensis oil was co-administered to mice at doses of 250, 500...

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Published in:	Anais da Academia Brasileira de Ciências Vol. 89; no. 3 Suppl; pp. 2043 - 2051
Main Authors:	Lemes, Susy R, Chaves, Dwight A, Silva, Júnior, Nelson J DA, Carneiro, Cristiene C, Chen-Chen, Lee, Almeida, Luciane M DE, Gonçalves, Pablo J, Melo-Reis, Paulo R DE
Format:	Journal Article
Language:	English
Published:	Brazil Academia Brasileira de Ciências 01-01-2017
Subjects:	Animals antigenotoxic Antimutagenic Agents - pharmacology Bone Marrow Cells - drug effects Carapa guianensis Cyclophosphamide - antagonists & inhibitors Disease Models, Animal Male Meliaceae Mice micronucleus Mitomycin - antagonists & inhibitors MULTIDISCIPLINARY SCIENCES oil Plant Extracts - pharmacology Plant Oils - pharmacology micronucleus Carapa guianensis oil antigenotoxic
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Summary:	The aim of this study was to evaluate the possible protective of C. guianensis oil against MMC and CP, which are direct- and indirect-acting chemical mutagens, using the micronucleus test. Three experiments were performed. First the C. guianensis oil was co-administered to mice at doses of 250, 500 and 1000 mg/kg bw with 4 mg/kg bw MMC or 50 mg/kg bw CP. Second, the mutagenic drug (CP) was administered ip 50 mg/kg bw and after 6 and 12 hours 250 and 500 mg/kg bw of C. guianensis oil were administered. In the last, C. guianensis oil was administrated (250 and 500 mg/kg bw) during five days and after it was administered ip 50 mg/kg bw CP. The results obtained showed that the C. guianensis oil is not cytotoxic neither genotoxic to mouse bone marrow. Regarding the antimutagenic effect, all doses of C. guianensis oil were significantly (p < 0.05) effective in reducing the frequency of micronucleated polychromatic erythrocytes, when compared with MMC or CP alone. Based on these results, our results suggest that the C. guianensis oil shows medicinal potential as an antimutagenic agent, modulating the mutagenicity caused by both direct- and indirect-acting chemical mutagens, in a mammalian model.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0001-3765 1678-2690 1678-2690
DOI:	10.1590/0001-3765201720150797