Search Results - "Carmody, Ruaidhrí J."

NF-κB and the Transcriptional Control of Inflammation by Mitchell, Jennifer P, Carmody, Ruaidhrí J

“…The NF-κB transcription factor was discovered 30 years ago and has since emerged as the master regulator of inflammation and immune homeostasis. It achieves…”
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The Regulation of NF-κB Subunits by Phosphorylation by Christian, Frank, Smith, Emma L, Carmody, Ruaidhrí J

“…The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates…”
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Toll-Like Receptors Drive Specific Patterns of Tolerance and Training on Restimulation of Macrophages by Butcher, Suzanne K, O'Carroll, Christine E, Wells, Christine A, Carmody, Ruaidhrí J

“…Tolerance is a long-recognized property of macrophages that leads to an altered response to repeated or chronic exposure to endotoxin. The physiological role…”
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Modulation of NF-κB Signaling as a Therapeutic Target in Autoimmunity by Herrington, Felicity D, Carmody, Ruaidhrí J, Goodyear, Carl S

“…Autoimmune diseases arise from the loss of tolerance to endogenous self-antigens, resulting in a heterogeneous range of chronic conditions that cause…”
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Negative Regulation of Toll-Like Receptor Signaling by NF-κB p50 Ubiquitination Blockade by Carmody, Ruaidhrí J, Ruan, Qingguo, Palmer, Scott, Hilliard, Brendan, Chen, Youhai H

“…Toll-like receptors (TLRs) trigger the production of inflammatory cytokines and shape adaptive and innate immunity to pathogens. We report the identification…”
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Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcription by Colleran, Amy, Collins, Patricia E., O’Carroll, Christine, Ahmed, Abrar, Mao, Xicheng, McManus, Bettina, Kiely, Patrick A., Burstein, Ezra, Carmody, Ruaidhrí J.

“…NF-κB is the master regulator of the immune response and is responsible for the transcription of hundreds of genes controlling inflammation and immunity…”
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CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis by Sarrou, Evgenia, Richmond, Laura, Carmody, Ruaidhrí J, Gibson, Brenda, Keeshan, Karen

“…Chromosomal rearrangements of the mixed lineage leukaemia ( , also known as ) gene on chromosome 11q23 are amongst the most common genetic abnormalities…”
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Essential Roles of c-Rel in TLR-Induced IL-23 p19 Gene Expression in Dendritic Cells by Carmody, Ruaidhri J, Ruan, Qingguo, Liou, Hsiou-Chi, Chen, Youhai H

“…IL-23 plays crucial roles in both immunity against pathogens and autoimmunity against self. Although it is well recognized that IL-23 expression is restricted…”
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Identification of a unique hybrid macrophage-polarization state following recovery from lipopolysaccharide tolerance by O'Carroll, Christine, Fagan, Ailís, Shanahan, Fergus, Carmody, Ruaidhrí J

“…LPS tolerance is an essential immune-homeostatic response to repeated exposure to LPS that prevents excessive inflammatory responses. LPS tolerance induces a…”
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The regulation of sequence specific NF-κB DNA binding and transcription by IKKβ phosphorylation of NF-κB p50 at serine 80 by Smith, Emma L, Somma, Domenico, Kerrigan, David, McIntyre, Zoe, Cole, John J, Liang, Kai Ling, Kiely, Patrick A, Keeshan, Karen, Carmody, Ruaidhrí J

“…Abstract Phosphorylation of the NF-κB transcription factor is an important regulatory mechanism for the control of transcription. Here we identify serine 80…”
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IĸB Protein BCL3 as a Controller of Osteogenesis and Bone Health by Jaffery, Hussain, Huesa, Carmen, Chilaka, Sabarinadh, Cole, John, Doonan, James, Akbar, Moeed, Dunning, Lynette, Tanner, Kathleen Elizabeth, ‘t Hof, Rob J., McInnes, Iain B., Carmody, Ruaidhrí J., Goodyear, Carl S.

“…Objective IĸB protein B cell lymphoma 3‐encoded protein (BCL3) is a regulator of the NF‐κB family of transcription factors. NF‐κB signaling fundamentally…”
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Inhibition of Transcription by B Cell Leukemia 3 (Bcl-3) Protein Requires Interaction with Nuclear Factor κB (NF-κB) p50 by Collins, Patricia E., Kiely, Patrick A., Carmody, Ruaidhrí J.

“…B cell leukemia 3 (Bcl-3) is an essential negative regulator of NF-κB during Toll-like receptor and TNF receptor signaling. Bcl-3 also interacts with a number…”
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Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells by Somma, Domenico, Kok, Fatma O, Kerrigan, David, Wells, Christine A, Carmody, Ruaidhrí J

“…Since its discovery over 30 years ago the NF-ĸB family of transcription factors has gained the status of master regulator of the immune response. Much of what…”
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A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling by Salomé, Mara, Magee, Aoife, Yalla, Krisha, Chaudhury, Shahzya, Sarrou, Evgenia, Carmody, Ruaidhrí J, Keeshan, Karen

“…Trib2 pseudokinase is involved in the etiology of a number of cancers including leukaemia, melanoma, ovarian, lung and liver cancer. Both high and low Trib2…”
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The Regulation of Endotoxin Tolerance and its Impact on Macrophage Activation by Collins, Patricia E, Carmody, Ruaidhri J

“…Endotoxin tolerance in macrophages is a key regulatory mechanism to limit the innate immune response to infection or injury. Long considered a state of…”
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Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis by Anderson, Amy E, Maney, Nicola J, Nair, Nisha, Lendrem, Dennis W, Skelton, Andrew J, Diboll, Julie, Brown, Philip M, Smith, Graham R, Carmody, Ruaidhrí J, Barton, Anne, Isaacs, John D, Pratt, Arthur G

“…Abstract Objectives Dysregulated signal transduction and activator of transcription-3 (STAT3) signalling in CD4+ T cells has been proposed as an early…”
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IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function by Ridgley, Laura A, Anderson, Amy E, Maney, Nicola J, Naamane, Najib, Skelton, Andrew J, Lawson, Catherine A, Emery, Paul, Isaacs, John D, Carmody, Ruaidhrí J, Pratt, Arthur G

“…We have previously shown that increased circulating interleukin-6 (IL-6) results in enhanced CD4+ T cell signaling via signal transduction and activator of…”
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Regulation of NF-κB by PML and PML-RARα by Ahmed, Abrar, Wan, Xiaochun, Mitxitorena, Izaskun, Lindsay, Andrew J., Paolo Pandolfi, Pier, McCaffrey, Mary W., Keeshan, Karen, Chen, Youhai H., Carmody, Ruaidhrí J.

“…Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic…”
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Assessing sites of NF-κB DNA binding using chromatin immunoprecipitation by Colleran, Amy, Collins, Patricia E, Carmody, Ruaidhrí J

“…The NF-κB transcription factor is in fact a family of related proteins which dimerize to form at least 12 distinct complexes which regulate the expression of…”
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Control of NF-κB subunits by ubiquitination by Collins, Patricia E, Colleran, Amy, Carmody, Ruaidhrí J

“…NF-κB is an essential regulator of inflammation and is also required for normal immune development and homeostasis. The inducible activation of NF-κB by a wide…”
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