Search Results - "Carmen Jerónimo"

Epigenetic biomarkers in urological tumors: A systematic review by Jerónimo, Carmen, Henrique, Rui

“…Abstract Prostate, bladder, kidney and testis cancers, the most common genitourinary (GU) neoplasms, are generally clinically silent at their earliest stages…”
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Protein phosphatase 1 in tumorigenesis: is it worth a closer look? by Felgueiras, Juliana, Jerónimo, Carmen, Fardilha, Margarida

“…Cancer cells take advantage of signaling cascades to meet their requirements for sustained growth and survival. Cell signaling is tightly controlled by…”
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DNA Methylation-Based Testing in Liquid Biopsies as Detection and Prognostic Biomarkers for the Four Major Cancer Types by Constâncio, Vera, Nunes, Sandra P, Henrique, Rui, Jerónimo, Carmen

“…Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal population-based cancer screening methods remain an unmet need, since…”
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Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic Targets by Miranda-Gonçalves, Vera, Lameirinhas, Ana, Henrique, Rui, Jerónimo, Carmen

“…Alterations in the epigenome and metabolism affect molecular rewiring of cancer cells facilitating cancer development and progression. Oncogene-driven…”
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Testicular Germ Cell Tumors Go Epigenetics: Will miR-371a-3p Replace Classical Serum Biomarkers? by Henrique, Rui, Jerónimo, Carmen

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Targeting the Immune system and Epigenetic Landscape of Urological Tumors by Lobo, João, Jerónimo, Carmen, Henrique, Rui

“…In the last years, we have witnessed remarkable advances in targeted therapies for cancer patients. There is a growing effort to either replace or reduce the…”
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In-air production of 3D co-culture tumor spheroid hydrogels for expedited drug screening by Antunes, Jéssica, Gaspar, Vítor M., Ferreira, Luís, Monteiro, Maria, Henrique, Rui, Jerónimo, Carmen, Mano, João F.

“…[Display omitted] Three-dimensional (3D) in vitro tumor spheroids are becoming popular as pre-clinical platforms for testing the performance of existing drugs…”
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Diagnostic and prognostic epigenetic biomarkers in cancer by Costa-Pinheiro, Pedro, Montezuma, Diana, Henrique, Rui, Jerónimo, Carmen

“…Growing cancer incidence and mortality worldwide demands development of accurate biomarkers to perfect detection, diagnosis, prognostication and monitoring…”
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Morphological and molecular heterogeneity in testicular germ cell tumors: implications for dedicated investigations by Lobo, João, Jerónimo, Carmen, Henrique, Rui

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From Therapy Resistance to Targeted Therapies in Prostate Cancer by Moreira-Silva, Filipa, Henrique, Rui, Jerónimo, Carmen

“…Prostate cancer (PCa) is the second most common malignancy among men worldwide. Although early-stage disease is curable, advanced stage PCa is mostly incurable…”
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Urinary Volatilomics Unveils a Candidate Biomarker Panel for Noninvasive Detection of Clear Cell Renal Cell Carcinoma by Pinto, Joana, Amaro, Filipa, Lima, Ana Rita, Carvalho-Maia, Carina, Jerónimo, Carmen, Henrique, Rui, Bastos, Maria de Lourdes, Carvalho, Márcia, Guedes de Pinho, Paula

“…Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer usually associated with asymptomatic development and risk of systemic…”
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Human Germ Cell Tumors are Developmental Cancers: Impact of Epigenetics on Pathobiology and Clinic by Lobo, João, Gillis, Ad J M, Jerónimo, Carmen, Henrique, Rui, Looijenga, Leendert H J

“…Current (high throughput omics-based) data support the model that human (malignant) germ cell tumors are not initiated by somatic mutations, but, instead…”
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Modulation of serine/threonine-protein phosphatase 1 (PP1) complexes: A promising approach in cancer treatment by Matos, Bárbara, Howl, John, Jerónimo, Carmen, Fardilha, Margarida

“…•The development of new and optimized anticancer therapies is an urgent requirement.•Serine/threonine-protein phosphatase 1 (PP1) has been recognized as a…”
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Profiling DNA Methylation Based on Next-Generation Sequencing Approaches: New Insights and Clinical Applications by Barros-Silva, Daniela, Marques, C Joana, Henrique, Rui, Jerónimo, Carmen

“…DNA methylation is an epigenetic modification that plays a pivotal role in regulating gene expression and, consequently, influences a wide variety of…”
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Integrative epigenetic taxonomy of primary prostate cancer by Stelloo, Suzan, Nevedomskaya, Ekaterina, Kim, Yongsoo, Schuurman, Karianne, Valle-Encinas, Eider, Lobo, João, Krijgsman, Oscar, Peeper, Daniel Simon, Chang, Seiwon Laura, Feng, Felix Yi-Chung, Wessels, Lodewyk Frederik Ary, Henrique, Rui, Jerónimo, Carmen, Bergman, Andries Marinus, Zwart, Wilbert

“…The Androgen Receptor (AR) is the key-driving transcription factor in prostate cancer, tightly controlled by epigenetic regulation. To date, most epigenetic…”
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Liquid Biopsies in the Clinical Management of Germ Cell Tumor Patients: State-of-the-Art and Future Directions by Lobo, João, Leão, Ricardo, Jerónimo, Carmen, Henrique, Rui

“…Liquid biopsies constitute a minimally invasive means of managing cancer patients, entailing early diagnosis, follow-up and prediction of response to therapy…”
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JmjC-KDMs KDM3A and KDM6B modulate radioresistance under hypoxic conditions in esophageal squamous cell carcinoma by Macedo-Silva, Catarina, Miranda-Gonçalves, Vera, Lameirinhas, Ana, Lencart, Joana, Pereira, Alexandre, Lobo, João, Guimarães, Rita, Martins, Ana Teresa, Henrique, Rui, Bravo, Isabel, Jerónimo, Carmen

“…Esophageal squamous cell carcinoma (ESCC), the most frequent esophageal cancer (EC) subtype, entails dismal prognosis. Hypoxia, a common feature of advanced…”
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Targeting histone deacetylases in testicular germ cell tumours: an encouraging treatment approach for the future by Tavares, Nuno Tiago, Henrique, Rui, Jerónimo, Carmen, Lobo, João

“…Epidrugs, specifically histone deacetylase inhibitors (HDACi), have been increasingly used in preclinical studies for the treatment of testicular germ cell…”
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Epigenetic Mechanisms Influencing Epithelial to Mesenchymal Transition in Bladder Cancer by Monteiro-Reis, Sara, Lobo, João, Henrique, Rui, Jerónimo, Carmen

“…Bladder cancer is one of the most incident neoplasms worldwide, and its treatment remains a significant challenge, since the mechanisms underlying disease…”
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Extracellular Vesicles as Potential Bladder Cancer Biomarkers: Take It or Leave It? by Teixeira-Marques, Ana, Lourenço, Catarina, Oliveira, Miguel Carlos, Henrique, Rui, Jerónimo, Carmen

“…Bladder cancer (BC) is the 10th most frequently diagnosed cancer worldwide. Although urine cytology and cystoscopy are current standards for BC diagnosis, both…”
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