Hyperbaric oxygen therapy for refractory radiation-induced hemorrhagic cystitis

Hyperbaric oxygen therapy for refractory radiation-induced hemorrhagic cystitis

Objectives To analyze the efficacy of hyperbaric oxygen for the treatment of radiation‐induced hemorrhagic cystitis and to identify factors associated with successful treatment. Methods Clinical records from 176 patients with refractory radiation‐induced hemorrhagic cystitis treated at the Portugues...

Full description

Saved in:
Bibliographic Details
Published in:International journal of urology Vol. 22; no. 10; pp. 962 - 966
Main Authors: Ribeiro de Oliveira, Tiago M, Carmelo Romão, António J, Gamito Guerreiro, Francisco M, Matos Lopes, Tomé M
Format: Journal Article
Language:English
Published: Australia Blackwell Publishing Ltd 01-10-2015
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Blood Transfusion
cystitis
Cystitis - etiology
Cystitis - therapy
Female
hematuria
Hematuria - etiology
Hematuria - therapy
Humans
hyperbaric oxygenation
Hyperbaric Oxygenation - methods
Male
Middle Aged
proctitis
Prostatic Neoplasms - radiotherapy
radiation injuries
Radiation Injuries - etiology
Radiation Injuries - therapy
Retreatment
Retrospective Studies
Treatment Outcome
Urinary Bladder - radiation effects
Uterine Cervical Neoplasms - radiotherapy
Young Adult
hematuria
hyperbaric oxygenation
cystitis
radiation injuries
proctitis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To analyze the efficacy of hyperbaric oxygen for the treatment of radiation‐induced hemorrhagic cystitis and to identify factors associated with successful treatment. Methods Clinical records from 176 patients with refractory radiation‐induced hemorrhagic cystitis treated at the Portuguese Navy Center for Underwater and Hyperbaric Medicine, during a 15‐year period, were retrospectively analyzed. Evolution of macroscopic hematuria was used to analyze treatment efficacy and correlated with other external variables. Results From a total of 176 treated patients, 23.9% evidenced other radiation‐induced soft tissue lesions. After an average on 37 sessions, 89.8% of patients showed resolution of hematuria, with only 1.7% of adverse events. In our sample, hematuria resolution after treatment with hyperbaric oxygen was statistically associated to the need for transfusion therapy (P = 0.026) and the number of sessions of hyperbaric oxygen (P = 0.042). No relationship was found with the remaining variables. Conclusions Refractory radiation‐induced hemorrhagic cystitis can be successfully and safely treated with hyperbaric oxygen. Treatment effectiveness seems to be correlated with the need for transfusion therapy and the number of sessions performed.
Bibliography:ArticleID:IJU12857
istex:6C256D3BD6E33AF742DEBFFED9E83D860D83C1E4
ark:/67375/WNG-KMR221J4-N
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0919-8172
1442-2042
DOI:10.1111/iju.12857