Search Results - "Carmella, Steven G."

Exposure and Metabolic Activation Biomarkers of Carcinogenic Tobacco-Specific Nitrosamines by Hecht, Stephen S, Stepanov, Irina, Carmella, Steven G

“…Lung cancer is the leading cause of cancer death in the world, and cigarette smoking is its main cause. Oral cavity cancer is another debilitating and often…”
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Increased acrolein–DNA adducts in buccal brushings of e-cigarette users by Cheng, Guang, Guo, Jiehong, Carmella, Steven G, Lindgren, Bruce, Ikuemonisan, Joshua, Niesen, Brittany, Jensen, Joni, Hatsukami, Dorothy K, Balbo, Silvia, Hecht, Stephen S

“…Abstract DNA adducts are central in the mechanism of carcinogenesis by genotoxic agents. We compared levels of a DNA adduct of acrolein, a genotoxic carcinogen…”
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Resolution and Quantitation of Mercapturic Acids Derived from Crotonaldehyde, Methacrolein, and Methyl Vinyl Ketone in the Urine of Smokers and Nonsmokers by Chen, Menglan, Carmella, Steven G, Li, Yupeng, Zhao, Yingchun, Hecht, Stephen S

“…Using improved HPLC analysis conditions, we report the separation of three isomers of mercapturic acid conjugates previously assigned in the literature only to…”
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CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study by Yuan, Jian-Min, Nelson, Heather H, Carmella, Steven G, Wang, Renwei, Kuriger-Laber, Jacquelyn, Jin, Aizhen, Adams-Haduch, Jennifer, Hecht, Stephen S, Koh, Woon-Puay, Murphy, Sharon E

“…Cytochrome P450 2A6 (CYP2A6) catalyzes the metabolism of nicotine and the tobacco-specific lung carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone…”
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Effects of cessation of cigarette smoking on eicosanoid biomarkers of inflammation and oxidative damage by McElroy, Joseph P, Carmella, Steven G, Heskin, Alisa K, Tang, Mei Kuen, Murphy, Sharon E, Reisinger, Sarah A, Jensen, Joni A, Hatsukami, Dorothy K, Hecht, Stephen S, Shields, Peter G

“…The urinary metabolites "prostaglandin E2 metabolite" (PGE-M) and (Z)-7-[1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid…”
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Rapid and Sustainable Detoxication of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China by EGNER, Patricia A, CHEN, Jian-Guo, FAHEY, Jed W, TALALAY, Paul, JIAN ZHU, CHEN, Tao-Yang, QIAN, Geng-Sun, CARMELLA, Steven G, HECHT, Stephen S, KENSLER, Thomas W, ZARTH, Adam T, NG, Derek K, WANG, Jin-Bing, KENSLER, Kevin H, JACOBSON, Lisa P, MUNOZ, Alvaro, JOHNSON, Jamie L, GROOPMAN, John D

“…Broccoli sprouts are a convenient and rich source of the glucosinolate, glucoraphanin, which can generate the chemopreventive agent, sulforaphane, an inducer…”
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Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer by Park, Sungshim L, Carmella, Steven G, Chen, Menglan, Patel, Yesha, Stram, Daniel O, Haiman, Christopher A, Le Marchand, Loic, Hecht, Stephen S

“…The Multiethnic Cohort epidemiology study has clearly demonstrated that, compared to Whites and for the same number of cigarettes smoked, African Americans and…”
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Polycyclic Aromatic Hydrocarbons and Pancreatic Cancer: An Analysis of the Blood Biomarker, r -1, t -2,3, c -4-Tetrahydroxy-1,2,3,4-tetrahydrophenanthrene and Selected Metabolism Gene SNPs by Nguyen, Sierra, Carlson, Heather, Yoder, Andrea, Bamlet, William R, Oberg, Ann L, Petersen, Gloria M, Carmella, Steven G, Hecht, Stephen S, Jansen, Rick J

“…Exposure to polycyclic aromatic hydrocarbons (PAHs), byproducts of incomplete combustion, and their effects on the development of cancer are still being…”
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Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China by Kensler, Thomas W., Ng, Derek, Carmella, Steven G., Chen, Menglan, Jacobson, Lisa P., Muñoz, Alvaro, Egner, Patricia A., Chen, Jian Guo, Qian, Geng Sun, Chen, Tao Yang, Fahey, Jed W., Talalay, Paul, Groopman, John D., Yuan, Jian-Min, Hecht, Stephen S.

“…Epidemiological evidence has suggested that consumption of a diet rich in cruciferous vegetables reduces the risk of several types of cancers and chronic…”
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Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai cohort study by Yuan, Jian‐Min, Nelson, Heather H., Butler, Lesley M., Carmella, Steven G., Wang, Renwei, Kuriger‐Laber, Jacquelyn K., Adams‐Haduch, Jennifer, Hecht, Stephen S., Gao, Yu‐Tang, Murphy, Sharon E.

“…Cytochrome P450 2A6 (CYP2A6) catalyzes nicotine metabolism and contributes to the metabolism of the tobacco‐specific lung carcinogen, NNK. Genetic variation in…”
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Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein by Chen, Menglan, Carmella, Steven G, Sipe, Chistopher, Jensen, Joni, Luo, Xianghua, Le, Chap T, Murphy, Sharon E, Benowitz, Neal L, McClernon, F Joseph, Vandrey, Ryan, Allen, Sharon S, Denlinger-Apte, Rachel, Cinciripini, Paul M, Strasser, Andrew A, al'Absi, Mustafa, Robinson, Jason D, Donny, Eric C, Hatsukami, Dorothy, Hecht, Stephen S

“…The urinary metabolites cyanoethyl mercapturic acid (CEMA) and 3-hydroxypropyl mercapturic acid (3-HPMA) have been widely used as biomarkers of exposure to…”
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Anthocyanins in black raspberries prevent esophageal tumors in rats by Wang, Li-Shu, Hecht, Stephen S, Carmella, Steven G, Yu, Nanxiong, Larue, Bethany, Henry, Cassandra, McIntyre, Colleen, Rocha, Claudio, Lechner, John F, Stoner, Gary D

“…Diets containing freeze-dried black raspberries (BRB) suppress the development of N-nitrosomethylbenzylamine (NMBA)-induced tumors in the rat esophagus. Using…”
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Acrolein Exposure in Hookah Smokers and Non-Smokers Exposed to Hookah Tobacco Secondhand Smoke: Implications for Regulating Hookah Tobacco Products by Kassem, Nada O.F., Kassem, Noura O., Liles, Sandy, Zarth, Adam T., Jackson, Sheila R., Daffa, Reem M., Chatfield, Dale A., Carmella, Steven G., Hecht, Stephen S., Hovell, Melbourne F.

“…Abstract Introduction Acrolein is a highly ciliatoxic agent, a toxic respiratory irritant, a cardiotoxicant, and a possible carcinogen present in tobacco smoke…”
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Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of Chinese women in Singapore who regularly cook at home by Hecht, Stephen S, Koh, Woon-Puay, Wang, Renwei, Chen, Menglan, Carmella, Steven G, Murphy, Sharon E, Yuan, Jian-Min

“…Lung cancer is unusually common among non-smoking women in Southeastern Asia but the causes of this frequently fatal disease are not well understood. Several…”
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Benzene Uptake and Glutathione S-transferase T1 Status as Determinants of S-Phenylmercapturic Acid in Cigarette Smokers in the Multiethnic Cohort by Haiman, Christopher A, Patel, Yesha M, Stram, Daniel O, Carmella, Steven G, Chen, Menglan, Wilkens, Lynne R, Le Marchand, Loic, Hecht, Stephen S

“…Research from the Multiethnic Cohort (MEC) demonstrated that, for the same quantity of cigarette smoking, African Americans and Native Hawaiians have a higher…”
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Metabolites of the Polycyclic Aromatic Hydrocarbon Phenanthrene in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer by Patel, Yesha M, Park, Sungshim L, Carmella, Steven G, Paiano, Viviana, Olvera, Natalie, Stram, Daniel O, Haiman, Christopher A, Le Marchand, Loic, Hecht, Stephen S

“…Results from the Multiethnic Cohort Study demonstrated significant differences in lung cancer risk among cigarette smokers from five different ethnic/racial…”
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Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation by Carmella, Steven G, Heskin, Alisa K, Tang, Mei Kuen, Jensen, Joni, Luo, Xianghua, Le, Chap T, Murphy, Sharon E, Benowitz, Neal L, McClernon, F Joseph, Vandrey, Ryan, Allen, Sharon S, Denlinger-Apte, Rachel, Cinciripini, Paul M, Strasser, Andrew A, al'Absi, Mustafa, Robinson, Jason D, Donny, Eric C, Hatsukami, Dorothy K, Hecht, Stephen S

“…The urinary metabolites (Z)-7-[1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid (8-iso-PGF2α), an F2-isoprostane and…”
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A Prospectively Measured Serum Biomarker for a Tobacco-Specific Carcinogen and Lung Cancer in Smokers by CHURCH, Timothy R, ANDERSON, Kristin E, CAPORASO, Neil E, GEISSER, Mindy S, LE, Chap T, YAN ZHANG, BENOIT, Adam R, CARMELLA, Steven G, HECHT, Stephen S

“…Background: No prior studies have related a tobacco-specific carcinogen to the risk of lung cancer in smokers. Of the over 60 known carcinogens in cigarette…”
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Quantitation of Acrolein-Derived (3-Hydroxypropyl)mercapturic Acid in Human Urine by Liquid Chromatography−Atmospheric Pressure Chemical Ionization Tandem Mass Spectrometry:  Effects of Cigarette Smoking by Carmella, Steven G, Chen, Menglan, Zhang, Yan, Zhang, Siyi, Hatsukami, Dorothy K, Hecht, Stephen S

“…Recently published data suggest that acrolein (1), a toxic but weakly carcinogenic constituent of cigarette smoke, may be involved as a causative factor for…”
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Nicotine Metabolism in Three Ethnic/Racial Groups with Different Risks of Lung Cancer by Derby, Kiersten S, Cuthrell, Kristine, Caberto, Christian, Carmella, Steven G, Franke, Adrian A, Hecht, Stephen S, Murphy, Sharon E, Le Marchand, Loïc

“…Previously, we documented that smoking-associated lung cancer risk is greater in Hawaiians and lower in Japanese compared with Whites. Nicotine metabolism by…”
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