Search Results - "Carmell, Michelle A."

A germline-specific class of small RNAs binds mammalian Piwi proteins by Carmell, Michelle A, Hannon, Gregory J, Girard, Angélique, Sachidanandam, Ravi

“…Small RNAs associate with Argonaute proteins and serve as sequence-specific guides to regulate messenger RNA stability, protein synthesis, chromatin…”
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Mammalian germ cells are determined after PGC colonization of the nascent gonad by Nicholls, Peter K., Schorle, Hubert, Naqvi, Sahin, Hu, Yueh-Chiang, Fan, Yuting, Carmell, Michelle A., Dobrinski, Ina, Watson, Adrienne L., Carlson, Daniel F., Fahrenkrug, Scott C., Page, David C.

“…Mammalian primordial germ cells (PGCs) are induced in the embryonic epiblast, before migrating to the nascent gonads. In fish, frogs, and birds, the germline…”
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Argonaute2 Is the Catalytic Engine of Mammalian RNAi by Liu, Jidong, Carmell, Michelle A., Rivas, Fabiola V., Marsden, Carolyn C., Thomson, J. Michael, Song, Ji-Joon, Hammond, Scott M., Joshua-Tor, Leemor, Hannon, Gregory J.

“…Gene silencing through RNA interference (RNAi) is carried out by RISC, the RNA-induced silencing complex. RISC contains two signature components, small…”
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A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes by Carmell, Michelle A, Dokshin, Gregoriy A, Skaletsky, Helen, Hu, Yueh-Chiang, van Wolfswinkel, Josien C, Igarashi, Kyomi J, Bellott, Daniel W, Nefedov, Michael, Reddien, Peter W, Enders, George C, Uversky, Vladimir N, Mello, Craig C, Page, David C

“…The advent of sexual reproduction and the evolution of a dedicated germline in multicellular organisms are critical landmarks in eukaryotic evolution. We…”
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Suppression of prion protein in livestock by RNA interference by Golding, M.C, Long, C.R, Carmell, M.A, Hannon, G.J, Westhusin, M.E

“…Given the difficulty of applying gene knockout technology to species other than mice, we decided to explore the utility of RNA interference (RNAi) in silencing…”
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GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability by Dokshin, Gregoriy A., Davis, Gregory M., Sawle, Ashley D., Eldridge, Matthew D., Nicholls, Peter K., Gourley, Taylin E., Romer, Katherine A., Molesworth, Luke W., Tatnell, Hannah R., Ozturk, Ahmet R., de Rooij, Dirk G., Hannon, Gregory J., Page, David C., Mello, Craig C., Carmell, Michelle A.

“…GCNA proteins are expressed across eukarya in pluripotent cells and have conserved functions in fertility. GCNA homologs Spartan (DVC-1) and Wss1 resolve…”
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RNase III enzymes and the initiation of gene silencing by Hannon, Gregory J, Carmell, Michelle A

“…Our understanding of RNA interference has been enhanced by new data concerning RNase III molecules. The role of Dicer has previously been established in RNAi…”
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Dicer is essential for mouse development by Hannon, Gregory J, Bernstein, Emily, Kim, Sang Yong, Carmell, Michelle A, Murchison, Elizabeth P, Alcorn, Heather, Li, Mamie Z, Mills, Alea A, Elledge, Stephen J, Anderson, Kathryn V

“…To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to…”
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The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis by Carmell, Michelle A, Xuan, Zhenyu, Zhang, Michael Q, Hannon, Gregory J

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MIWI2 Is Essential for Spermatogenesis and Repression of Transposons in the Mouse Male Germline by Carmell, Michelle A., Girard, Angélique, van de Kant, Henk J.G., Bourc'his, Deborah, Bestor, Timothy H., de Rooij, Dirk G., Hannon, Gregory J.

“…Small RNAs associate with Argonaute proteins and serve as sequence-specific guides for regulation of mRNA stability, productive translation, chromatin…”
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Germline transmission of RNAi in mice by Rosenquist, Thomas A, Carmell, Michelle A, Zhang, Liqun, Conklin, Douglas S, Hannon, Gregory J

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