Search Results - "Carme, Masdeu"

Recent advances of the Povarov reaction in medicinal chemistry by Ghashghaei, Ouldouz, Masdeu, Carme, Alonso, Concepción, Palacios, Francisco, Lavilla, Rodolfo

“…[Display omitted] The Povarov multicomponent reaction consists on the condensation of an aniline, an aldehyde, and an activated olefin to generate a…”
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Fused 1,5-Naphthyridines: Synthetic Tools and Applications by Masdeu, Carme, Fuertes, Maria, Martin-Encinas, Endika, Selas, Asier, Rubiales, Gloria, Palacios, Francisco, Alonso, Concepcion

“…Heterocyclic nitrogen compounds, including fused 1,5-naphthyridines, have versatile applications in the fields of synthetic organic chemistry and play an…”
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Synthetic Strategies, Reactivity and Applications of 1,5-Naphthyridines by Fuertes, Maria, Masdeu, Carme, Martin-Encinas, Endika, Selas, Asier, Rubiales, Gloria, Palacios, Francisco, Alonso, Concepcion

“…This review covers the synthesis and reactivity of 1,5-naphthyridine derivatives published in the last 18 years. These heterocycles present a significant…”
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Gel-Free Tools for Quick and Simple Screening of Anti-Topoisomerase 1 Compounds by Keller, Josephine Geertsen, Petersen, Kamilla Vandsø, Mizielinski, Karol, Thiesen, Celine, Bjergbæk, Lotte, Reguera, Rosa M, Pérez-Pertejo, Yolanda, Balaña-Fouce, Rafael, Trejo, Angela, Masdeu, Carme, Alonso, Concepcion, Knudsen, Birgitta R, Tesauro, Cinzia

“…With the increasing need for effective compounds against cancer or pathogen-borne diseases, the development of new tools to investigate the enzymatic activity…”
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Highly Enantioselective Conjugate Additions of Aldehydes to Vinyl Sulfones by Landa, Aitor, Maestro, Miguel, Masdeu, Carme, Puente, Ángel, Vera, Silvia, Oiarbide, Mikel, Palomo, Claudio

“…Joined together, organocatalysts aldehydes and sulfones: A diaryl prolinol silyl ether was found to catalyse efficiently and enantioselectively the conjugate…”
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In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma by Pérez-Salvia, Montserrat, Aldaba, Eneko, Vara, Yosu, Fabre, Myriam, Ferrer, Cristina, Masdeu, Carme, Zubia, Aizpea, Sebastian, Eider San, Otaegui, Dorleta, Llinàs-Arias, Pere, Rosselló-Tortella, Margalida, Berdasco, Maria, Moutinho, Catia, Setien, Fernando, Villanueva, Alberto, González-Barca, Eva, Muncunill, Josep, Navarro, José-Tomás, Piris, Miguel A, Cossio, Fernando P, Esteller, Manel

“…Cancer origin and development is associated not only with genetic alterations, but also with the disturbance of epigenetic profiles.1 In this regard, the…”
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Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions by Trejo, Angela, Masdeu, Carme, Serrano-Pérez, Irene, Pedrola, Marina, Juanola, Narcís, Ghashghaei, Ouldouz, Jiménez-Galisteo, Guadalupe, Lavilla, Rodolfo, Palacios, Francisco, Alonso, Concepción, Viñas, Miguel

“…New antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with…”
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A patent review of topoisomerase I inhibitors (2016-present) by Selas, Asier, Martin-Encinas, Endika, Fuertes, Maria, Masdeu, Carme, Rubiales, Gloria, Palacios, Francisco, Alonso, Concepción

“…Topoisomerases are important targets for therapeutic improvement in the treatment of some diseases, including cancer. Inhibitors and poisons of topoisomerase I…”
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The Intramolecular Povarov Tool in the Construction of Fused Nitrogen-Containing Heterocycles by Masdeu, Carme, de los Santos, Jesús M., Palacios, Francisco, Alonso, Concepción

“…Nitrogen heterocycles are part of the structure of natural products and agents with important biological activity, such as antiviral, antibiotic, and antitumor…”
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Formation of γ-Oxoacids and 1 H -Pyrrol-2(5 H )-ones from α,β-Unsaturated Ketones and Ethyl Nitroacetate by Aginagalde, Maialen, Bello, Tamara, Masdeu, Carme, Vara, Yosu, Arrieta, Ana, Cossío, Fernando P.

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Abstract 4725: Efficacy of a new small-molecule inhibitor of histone deacetylase 6 (HDAC6) in preclinical models of B-cell lymphoma and acute myeloid leukemia by Villanueva, Lorea, Perez-Salvia, Montserrat, Aldaba, Eneko, Vara, Yosu, Fabre, Myriam, Ferrer, Cristina, Masdeu, Carme, Zubia, Aizpea, Sebastian, Eider San, Otaegui, Dorleta, Llinàs-Arias, Pere, Rosselló-Tortella, Margalida, Berdasco, María, Setien, Fernando, Moutinho, Catia, Villanueva, Alberto, González-Barca, Eva, Muncunill, Josep, Navarro, José Tomás, Piris, Miguel Ángel, Cossio, Fernando, Esteller, Manel

“…Histone deacetylase 6 (HDAC6) is a protein modifier that is an increasingly attractive pharmacological target. Interestingly, the observation that the HDAC6…”
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Formation of γ-Oxoacids and 1H-Pyrrol-2(5H)-ones from α,β-Unsaturated Ketones and Ethyl Nitroacetate by Aginagalde, Maialen, Bello, Tamara, Masdeu, Carme, Vara, Yosu, Arrieta, Ana, Cossío, Fernando P

“…Michael addition of ethyl nitroacetate on α,β-unsaturated ketones followed by Nef oxidation under hydrolytic conditions yields γ-oxoacids instead of the…”
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Efficacy of a New Small-Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) in Preclinical Models of B-Cell Lymphoma and Acute Myeloid Leukemia by Perez-Salvia, Montserrat, Eneko, Aldaba, Yosu, Vara, Myriam, Fabre, Cristina, Ferrer, Carme, Masdeu, Aizpea, Zubia, Eider, San Sebastian, Dorleta, Otaegui, Pere, Llinàs-Arias, Margalida, Rosselló-Tortella, Maria, Berdasco, Fernando, Setien, Catia, Moutinho, Alberto, Villanueva, González-Barca, Eva, Muncunill, Josep, Navarro, Jose Tomas, Piris, Miguel Angel, Fernando, Cossio, Esteller, Manel

“…Histone deacetylase 6 (HDAC6) is a protein modifier that is an increasingly attractive pharmacological target. Interestingly, the observation that the HDAC6…”
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In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma by Pérez Salvia, Montserrat, Aldaba, Eneko, Vara, Yosu, Fabre, Myriam, Ferrer, Cristina, Masdeu, Carme, Zubia, Aizpea, San Sebastian, Eider, Otaegui, Dorleta, Llinàs-Arias, Pere, Rosselló-Tortella, Margalida, Berdasco, María, Moutinho, Cátia, Setién, Fernando, Villanueva Garatachea, Alberto, González Barca, Eva, Muncunill, Josep, Navarro, José-Tomás, Piris, Miguel A, Cossio, Fernando P, Esteller, Manel

“…Cancer origin and development is associated not only with genetic alterations, but also with the disturbance of epigenetic profiles.1 In this regard, the…”
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Double Insertion of Isocyanides into Dihydropyridines: Direct Access to Substituted Benzimidazolium Salts by Masdeu, Carme, Gómez, Elena, Williams, Nana Aba O., Lavilla, Rodolfo

“…Double agent: The insertion of two isocyanide molecules into the dihydropyridine ring in the presence of iodine results in the formation of a benzimidazole…”
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Isocyanide Addition to Pyridinium Salts. Efficient Entry into Substituted Nicotinonitrile Derivatives by Williams, Nana Aba O, Masdeu, Carme, Díaz, José Luis, Lavilla, Rodolfo

“…The addition of isocyanides to pyridinium salts is studied. The process takes place efficiently when a carboxamido group is present in the 3 position of the…”
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Multicomponent Access to Functionalized Mesoionic Structures Based on TFAA Activation of Isocyanides: Novel Domino Reactions by Arévalo, María José, Kielland, Nicola, Masdeu, Carme, Miguel, Miriam, Isambert, Nicolas, Lavilla, Rodolfo

“…The reactions of azines (isoquinolines, pyridine) with TFAA and isocyanides in a new domino process yield mesoionic acid fluorides with an imidazo[1,2‐a]azine…”
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Development and validation of a LC-MS assay for the quantification of ikh12 a novel anti-tumor candidate in rat plasma and tissues and its application in a pharmacokinetic study by Otaegui, Dorleta, Masdeu, Carme, Aldaba, Eneko, Vara, Yosu, Zubia, Aizpea, San Sebastian, Eider, Alcalá, Maria, Villafruela, Sergio, Cossío, Fernando P., Rodriguez-Gascón, Alicia

“…IKH12 is a novel histone deacetylase 6 selective inhibitor. A rapid and sensitive liquid chromatography tandem mass spectrometry method was developed and…”
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Benzimidazolium Salts as Small, Nonpeptidic and BBB-Permeable Human Prolyl Oligopeptidase Inhibitors by Tarragó, Teresa, Masdeu, Carme, Gómez, Elena, Isambert, Nicolás, Lavilla, Rodolfo, Giralt, Ernest

“…Prolyl oligopeptidase (POP) is a cytosolic serine peptidase that hydrolyzes proline‐containing peptides at the carboxy terminus of proline residues. This…”
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Straightforward α-carbamoylation of NADH-like dihydropyridines and enol ethers by Masdeu, Carme, Dı́az, José Luis, Miguel, Miriam, Jiménez, Oscar, Lavilla, Rodolfo

“…[Display omitted] The protonation of NADH-like dihydropyridines and cyclic enol ethers generates reactive cationic intermediates, which interact with…”
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