Search Results - "Carlton, Mark B.L."

Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens by Gilmour, Darren T., Lyon, Gholson J., Carlton, Mark B.L., Sanes, Joshua R., Cunningham, Jeanette M., Anderson, Janice R., Hogan, Brigid L.M., Evans, Martin J., Colledge, William H.

“…SPARC (secreted protein acidic and rich in cysteine, also known as osteonectin/BM40) is a secreted Ca2+‐binding glycoprotein that interacts with a range of…”
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Synthetic chemerin-derived peptides suppress inflammation through ChemR23 by Cash, Jenna L, Hart, Rosie, Russ, Andreas, Dixon, John P C, Colledge, William H, Doran, Joanne, Hendrick, Alan G, Carlton, Mark B L, Greaves, David R

“…Chemerin is a chemotactic protein that binds to the G protein-coupled receptor, ChemR23. We demonstrate that murine chemerin possesses potent antiinflammatory…”
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Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene by d'Anglemont de Tassigny, Xavier, Fagg, Lisa A, Dixon, John P.C, Day, Kate, Leitch, Harry G, Hendrick, Alan G, Zahn, Dirk, Franceschini, Isabelle, Caraty, Alain, Carlton, Mark B.L, Aparicio, Samuel A.J.R, Colledge, William H

“…The G protein-coupled receptor GPR54 (AXOR12, OT7T175) is central to acquisition of reproductive competency in mammals. Peptide ligands (kisspeptins) for this…”
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Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse by Prömel, Simone, Waller-Evans, Helen, Dixon, John, Zahn, Dirk, Colledge, William H., Doran, Joanne, Carlton, Mark B.L., Grosse, Johannes, Schöneberg, Torsten, Russ, Andreas P., Langenhan, Tobias

“…Background: Adhesion G protein‐coupled receptors (aGPCR) constitute a structurally and functionally diverse class of seven‐transmembrane receptor proteins…”
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stella Is a Maternal Effect Gene Required for Normal Early Development in Mice by Payer, Bernhard, Saitou, Mitinori, Barton, Sheila C., Thresher, Rosemary, Dixon, John P.C., Zahn, Dirk, Colledge, William H., Carlton, Mark B.L., Nakano, Toru, Surani, M.Azim

“…stella is a novel gene specifically expressed in primordial germ cells, oocytes, preimplantation embryos, and pluripotent cells [1, 2]. It encodes a protein…”
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The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development by Warren, A J, Colledge, W H, Carlton, M B, Evans, M J, Smith, A J, Rabbitts, T H

“…The LIM domain protein rbtn2 is associated with T cell acute leukemias. We demonstrate that rbtn2 is a nuclear protein expressed in the erythroid lineage in…”
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A retroviral Gene Trap Insertion into the Histone 3.3A Gene Causes Partial Neonatal Lethality, Stunted Growth, Neuromuscular Deficits and Male Sub-fertility in Transgenic Mice by Couldrey, Christine, Carlton, Mark B.L., Nolan, Patrick M., Colledge, William H., Evans, Martin J.

“…Spermatogenesis is a complex developmental process involving cell division and differentiation. Approximately half of all sterile males have defects in…”
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A Phase I, First-in-Human, Healthy Volunteer Study to Investigate the Safety, Tolerability, and Pharmacokinetics of CVN424, a Novel G Protein-Coupled Receptor 6 Inverse Agonist for Parkinson's Disease by Margolin, David H, Brice, Nicola L, Davidson, Antonia M, Matthews, Kim L, Carlton, Mark B L

“…CVN424 is a novel small molecule and first-in-class candidate therapeutic to selectively modulate GPR6, an orphan G-protein coupled receptor. Expression of…”
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Mismatch negativity as an index of target engagement for excitation/inhibition-based treatment development: a double-blind, placebo-controlled, randomized, single-dose cross-over study of the serotonin type-3 receptor antagonist CVN058 by Sehatpour, Pejman, Javitt, Daniel C, De Baun, Heloise M, Carlson, Marlene, Beloborodova, Anna, Margolin, David H, Carlton, Mark B L, Brice, Nicola L, Kantrowitz, Joshua T

“…Serotonin type-3 receptor (5-HT R) antagonists show potential as a treatment for cognitive deficits in schizophrenia. CVN058, a brain-penetrant, potent and…”
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Kisspeptin Can Stimulate Gonadotropin-Releasing Hormone (GnRH) Release by a Direct Action at GnRH Nerve Terminals by d'Anglemont de Tassigny, Xavier, Fagg, Lisa A, Carlton, Mark B. L, Colledge, William H

“…The G protein-coupled receptor GPR54, and its peptide ligand kisspeptin (Kp), are crucial for the induction and maintenance of mammalian reproductive function…”
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Insulin-like peptide 5 is an orexigenic gastrointestinal hormone by Grosse, Johannes, Heffron, Helen, Burling, Keith, Hossain, Mohammed Akhter, Habib, Abdella M., Rogers, Gareth J., Richards, Paul, Larder, Rachel, Rimmington, Debra, Adriaenssens, Alice A., Parton, Laura, Powell, Justin, Binda, Matteo, Colledge, William H., Doran, Joanne, Toyoda, Yukio, Wade, John D., Aparicio, Samuel, Carlton, Mark B. L., Coll, Anthony P., Reimann, Frank, O'Rahilly, Stephen, Gribble, Fiona M.

“…The gut endocrine system is emerging as a central player in the control of appetite and glucose homeostasis, and as a rich source of peptides with therapeutic…”
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Kisspeptin Directly Stimulates Gonadotropin-Releasing Hormone Release via G Protein-Coupled Receptor 54 by Messager, Sophie, Chatzidaki, Emmanouella E., Ma, Dan, Hendrick, Alan G., Zahn, Dirk, Dixon, John, Thresher, Rosemary R., Malinge, Isabelle, Lomet, Didier, Mark B. L. Carlton, Colledge, William H., Caraty, Alain, Samuel A. J. R. Aparicio, Brenner, Sydney

“…We have recently described a molecular gatekeeper of the hypothalamic-pituitary-gonadal axis with the observation that G protein-coupled receptor 54 (GPR54) is…”
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The GPR54 Gene as a Regulator of Puberty by Seminara, Stephanie B, Messager, Sophie, Chatzidaki, Emmanouella E, Thresher, Rosemary R, Acierno, James S, Shagoury, Jenna K, Bo-Abbas, Yousef, Kuohung, Wendy, Schwinof, Kristine M, Hendrick, Alan G, Zahn, Dirk, Dixon, John, Kaiser, Ursula B, Slaugenhaupt, Susan A, Gusella, James F, O'Rahilly, Stephen, Carlton, Mark B.L, Crowley, William F, Aparicio, Samuel A.J.R, Colledge, William H

“…Puberty does not occur in patients with idiopathic hypogonadotropic hypogonadism. This study investigated mutations in a candidate gene encoding a G…”
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The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse by Waller-Evans, Helen, Prömel, Simone, Langenhan, Tobias, Dixon, John, Zahn, Dirk, Colledge, William H, Doran, Joanne, Carlton, Mark B L, Davies, Ben, Aparicio, Samuel A J R, Grosse, Johannes, Russ, Andreas P

“…Adhesion-GPCRs provide essential cell-cell and cell-matrix interactions in development, and have been implicated in inherited human diseases like Usher…”
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Eomesodermin is required for mouse trophoblast development and mesoderm formation by Russ, Andreas P, Wattler, Sigrid, Colledge, William H, Aparicio, Samuel A. J. R, Carlton, Mark B. L, Pearce, Jonathan J, Barton, Sheila C, Surani, M. Azim, Ryan, Kenneth, Nehls, Michael C, Wilson, Valerie, Evans, Martin J

“…The earliest cell fate decision in the mammalian embryo separates the extra-embryonic trophoblast lineage, which forms the fetal portion of the placenta, from…”
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Thymic lymphomas in mice with a truncating mutation in Brca2 by FRIEDMAN, L. S, THISTLETHWAITE, F. C, EVANS, M. J, PONDER, B. A. J, PATEL, K. J, YU, V. P. C. C, HYUNSOOK LEE, VENKITARAMAN, A. R, ABEL, K. J, CARLTON, M. B. L, HUNTER, S. M, COLLEDGE, W. H

“…Inherited mutations in the BRCA2 gene predispose women to breast and ovarian cancer. We created a mutation in the mouse Brca2 gene that terminates translation…”
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Gene trapping and functional genomics by Evans, Martin J., Carlton, Mark B.L., Russ, Andreas P.

“…Classical genetics depends upon investigation of function by random destruction with little information on structure. Modern mapping using random…”
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Crouzon‐like craniofacial dysmorphology in the mouse is caused by an insertional mutation at the Fgf3/Fgf4 locus by Carlton, Mark B.L., Colledge, William H., Evans, Martin J.

“…Retroviral insertional mutagenesis by means of ES cells has resulted in a new autosomal dominant mutation causing craniofacial dysmorphology in the mouse…”
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Crouzon-like craniofacial dysmorphology in the mouse is caused by an insertional mutation at theFgf3/Fgf4 locus by Carlton, Mark B.L., Colledge, William H., Evans, Martin J.

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Gene trapping and functional genomics by Evans, Martin J., Carlton, Mark B.L., Russ, Andreas P.

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