Search Results - "Carlsten, M."

The cellular immune system in myelomagenesis: NK cells and T cells in the development of MM and their uses in immunotherapies by Dosani, T, Carlsten, M, Maric, I, Landgren, O

“…As vast strides are being made in the management and treatment of multiple myeloma (MM), recent interests are increasingly focusing on understanding the…”
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DIRECT PARENCHYMAL DELIVERY TO ANY ORGAN OR TUMOR VIA NEXT GENERATION ENDOVASCULAR TECHNIQUE – MINIMALLY INVASIVE AND EFFICIENT METHOD FOR TARGETED CELL AND GENE THERAPY by Al-Saadi, J., Waldén, M., Sohlmér, J., Grankvist, R., Friberger, I., Andersson, A., Lövljung, V., Settergren, M., Carlsten, M., Chien, K., Lundberg, J., Witman, N., Holmin, S.

“…A fundamental problem for cell/gene/drug delivery is to achieve right location, concentration and time. More specifically, the successful development of cell…”
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Coordinated expression of DNAM-1 and LFA-1 in educated NK cells by Enqvist, Monika, Ask, Eivind Heggernes, Forslund, Elin, Carlsten, Mattias, Abrahamsen, Greger, Béziat, Vivien, Andersson, Sandra, Schaffer, Marie, Spurkland, Anne, Bryceson, Yenan, Önfelt, Björn, Malmberg, Karl-Johan

“…The functional capacity of NK cells is dynamically tuned by integrated signals from inhibitory and activating cell surface receptors in a process termed NK…”
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The cellular immune system in myelomagenesis: NK cells and T cells in the development of MM and their uses in immunotherapies by Dosani, T, Carlsten, M, Maric, I, Landgren, O

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Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34 blasts in myelodysplastic syndrome by Carlsten, M, Baumann, B C, Simonsson, M, Jädersten, M, Forsblom, A-M, Hammarstedt, C, Bryceson, Y T, Ljunggren, H-G, Hellström-Lindberg, E, Malmberg, K-J

“…Myelodysplastic syndromes (MDS) comprise a heterogeneous group of clonal stem-cell disorders characterized by ineffective hematopoiesis and risk of progression…”
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54 ADOPTIVELY TRANSFERRED HAPLOIDENTICAL NK CELLS AGAINST REFRACTORY MDS, HIGH-RISK MDS AND REFRACTORY AML AS A BRIDGE TO TRANSPLANTATION. COMPLETE REMISSION ASSOCIATED WITH DETECTABLE NK CELLS by Bjorklund, A.T, Carlsten, M, Liu, L, Schaffer, M, Watz, E, Palma, M, Hansson, L, Mollgard, L, Cooley, S.A, Miller, J.S, Ljungman, P.T, Hellstrom-Lindberg, E, Ljunggren, H.G, Malmberg, K.J

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Natural Killer Cells in Myeloid Malignancies: Immune Surveillance, NK Cell Dysfunction, and Pharmacological Opportunities to Bolster the Endogenous NK Cells by Carlsten, Mattias, Järås, Marcus

“…Natural killer (NK) cells are large granular lymphocytes involved in our defense against certain virus-infected and malignant cells. In contrast to T cells, NK…”
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Harnessing upregulated E-selectin while enhancing SDF-1α sensing redirects infused NK cells to the AML-perturbed bone marrow by Sanz-Ortega, Laura, Andersson, Agneta, Carlsten, Mattias

“…Increased bone marrow (BM) homing of NK cells is associated with positive outcome in patients with acute myeloid leukemia (AML) treated within adoptive NK cell…”
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Sugar Free: Novel Immunotherapeutic Approaches Targeting Siglecs and Sialic Acids to Enhance Natural Killer Cell Cytotoxicity Against Cancer by Daly, John, Carlsten, Mattias, O'Dwyer, Michael

“…Natural Killer (NK) cells are cytotoxic lymphocytes that play a key role in the immune system, targeting and destroying invading pathogens and malignantly…”
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Natural killer cell-mediated immunosurveillance of human cancer by Malmberg, Karl-Johan, Carlsten, Mattias, Björklund, Andreas, Sohlberg, Ebba, Bryceson, Yenan T., Ljunggren, Hans-Gustaf

“…The contribution of natural killer (NK) cells to immunosurveillance of human cancer remains debatable. Here, we discuss advances in several areas of human NK…”
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Cytokines Orchestrating the Natural Killer-Myeloid Cell Crosstalk in the Tumor Microenvironment: Implications for Natural Killer Cell-Based Cancer Immunotherapy by Gaggero, Silvia, Witt, Kristina, Carlsten, Mattias, Mitra, Suman

“…Natural killer (NK) cells are endowed with germline-encoded receptors that enable them to detect and kill malignant cells without prior priming. Over the…”
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Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML by Björklund, Andreas T, Carlsten, Mattias, Sohlberg, Ebba, Liu, Lisa L, Clancy, Trevor, Karimi, Mohsen, Cooley, Sarah, Miller, Jeffrey S, Klimkowska, Monika, Schaffer, Marie, Watz, Emma, Wikström, Kristina, Blomberg, Pontus, Wahlin, Björn Engelbrekt, Palma, Marzia, Hansson, Lotta, Ljungman, Per, Hellström-Lindberg, Eva, Ljunggren, Hans-Gustaf, Malmberg, Karl-Johan

“…To evaluate the safety, efficacy, and immunobiological correlates of allogeneic NK-cell-based therapy in primary chemotherapy-refractory or relapsed high-risk…”
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Comprehensive Exploration of NK Cell Education in ADCC Triggered By a Monoclonal Antibody or a Bispecific Killer Engager Molecule (BiKE) by Leijonhufvud, Caroline, Schlums, Heinrich, Stikvoort, Arwen, Uhlin, Michael, Bryceson, Yenan T, Carlsten, Mattias

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KIR2DS1 and KIR2DL1-C245 Dominantly Repress NK Cell Degranulation Triggered by Monoclonal or Bispecific Antibodies, whereas Education by Uptuning Inhibitory Killer Ig-related Receptors Exerts No Advantage in Ab-dependent Cellular Cytotoxicity by Leijonhufvud, Caroline, Sanz-Ortega, Laura, Schlums, Heinrich, Gaballa, Ahmed, Andersson, Agneta, Eriksson, Caroline, Segerberg, Filip, Uhlin, Michael, Bryceson, Yenan T, Carlsten, Mattias

“…NK cell responsiveness to target cells is tuned by interactions between inhibitory NK cell receptors and their cognate HLA class I ligands in a process termed…”
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Enhanced Bone Marrow Homing of Natural Killer Cells Following mRNA Transfection With Gain-of-Function Variant CXCR4R334X by Levy, Emily, Reger, Robert, Segerberg, Filip, Lambert, Melanie, Leijonhufvud, Caroline, Baumer, Yvonne, Carlsten, Mattias, Childs, Richard

“…Adoptive transfer of natural killer (NK) cells can induce remission in patients with relapsed/refractory leukemia and myeloma. However, to date, clinical…”
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Perturbed epigenetic transcriptional regulation in AML with IDH mutations causes increased susceptibility to NK cells by Palau, Anna, Segerberg, Filip, Lidschreiber, Michael, Lidschreiber, Katja, Naughton, Aonghus J., Needhamsen, Maria, Jung, Lisa Anna, Jagodic, Maja, Cramer, Patrick, Lehmann, Sören, Carlsten, Mattias, Lennartsson, Andreas

“…Isocitrate dehydrogenase (IDH) mutations are found in 20% of acute myeloid leukemia (AML) patients. However, only 30–40% of the patients respond to IDH…”
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Primary Human Tumor Cells Expressing CD155 Impair Tumor Targeting by Down-Regulating DNAM-1 on NK Cells by Carlsten, Mattias, Norell, Hakan, Bryceson, Yenan T, Poschke, Isabel, Schedvins, Kjell, Ljunggren, Hans-Gustaf, Kiessling, Rolf, Malmberg, Karl-Johan

“…The activating NK cell receptor DNAX accessory molecule-1 (DNAM-1) contributes to tumor immune surveillance and plays a crucial role in NK cell-mediated…”
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CRISPR/Cas9-Based Gene Engineering of Human Natural Killer Cells: Protocols for Knockout and Readouts to Evaluate Their Efficacy by Lambert, Mélanie, Leijonhufvud, Caroline, Segerberg, Filip, Melenhorst, J Joseph, Carlsten, Mattias

“…Natural killer (NK) cells are cytotoxic lymphocytes of our immune system with the ability to identify and kill certain virally infected and tumor-transformed…”
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The value of complete remission according to positron emission tomography prior to autologous stem cell transplantation in lymphoma: a population-based study showing improved outcome by Noring, Kristina, Carlsten, Mattias, Sonnevi, Kristina, Wahlin, Björn Engelbrekt

“…Chimeric antigen-receptor T-cell and bispecific antibody therapies will likely necessitate a reconsideration of the role of autologous stem-cell…”
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Body composition measurements and risk of hematological malignancies: A population-based cohort study during 20 years of follow-up by Hagström, Hannes, Andreasson, Anna, Carlsson, Axel C, Jerkeman, Mats, Carlsten, Mattias

“…High body mass index (BMI) is associated with development of hematological malignancies (HMs). However, although BMI is a well-established measurement of…”
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