Search Results - "Carlsson, Michael C."

Extracellular and intracellular small-molecule galectin-3 inhibitors by Stegmayr, John, Zetterberg, Fredrik, Carlsson, Michael C., Huang, Xiaoli, Sharma, Gunjan, Kahl-Knutson, Barbro, Schambye, Hans, Nilsson, Ulf J., Oredsson, Stina, Leffler, Hakon

“…Galectin-3 is a carbohydrate binding protein which has important roles in cancer and immunity. Potent galectin-3 inhibitors have been synthesized, for…”
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Ligand binding and complex formation of galectin-3 is modulated by pH variations by von Mach, Tobias, Carlsson, Michael C, Straube, Tamara, Nilsson, Ulf, Leffler, Hakon, Jacob, Ralf

“…Galectin-3-dependent clusters or lattices are formed at the surface as well as in distinct organelles of eukaryotic cells. Incorporation into membrane proximal…”
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Galectin-3 endocytosis by carbohydrate independent and dependent pathways in different macrophage like cell types by Lepur, Adriana, Carlsson, Michael C., Novak, Ruđer, Dumić, Jerka, Nilsson, Ulf J., Leffler, Hakon

“…Galectin-3 (the Mac-2 antigen) is abundantly expressed in both macrophage like cells and certain non-macrophage cells. We have studied endocytosis of…”
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Mutational Tuning of Galectin-3 Specificity and Biological Function by Salomonsson, Emma, Carlsson, Michael C., Osla, Veronica, Hendus-Altenburger, Ruth, Kahl-Knutson, Barbro, Öberg, Christopher T., Sundin, Anders, Nilsson, Rickard, Nordberg-Karlsson, Eva, Nilsson, Ulf J., Karlsson, Anna, Rini, James M., Leffler, Hakon

“…Galectins are defined by a conserved β-galactoside binding site that has been linked to many of their important functions in e.g. cell adhesion, signaling, and…”
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Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface by Carlsson, Susanne, Öberg, Christopher T, Carlsson, Michael C, Sundin, Anders, Nilsson, Ulf J, Smith, David, Cummings, Richard D, Almkvist, Jenny, Karlsson, Anna, Leffler, Hakon

“…Galectin-8 has two different carbohydrate recognition domains (CRDs), the N-terminal Gal-8N and the C-terminal Gal-8C linked by a peptide, and has various…”
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Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients by Carlsson, Michael C, Cederfur, Cecilia, Schaar, Viveka, Balog, Crina I A, Lepur, Adriana, Touret, Franck, Salomonsson, Emma, Deelder, André M, Fernö, Mårten, Olsson, Håkan, Wuhrer, Manfred, Leffler, Hakon

“…Sera from 25 metastatic breast cancer patients and 25 healthy controls were subjected to affinity chromatography using immobilized galectin-1. Serum from the…”
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Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context by Nielsen, Mathias Ingemann, Stegmayr, John, Grant, Oliver C., Yang, Zhang, Nilsson, Ulf J., Boos, Irene, Carlsson, Michael C., Woods, Robert J., Unverzagt, Carlo, Leffler, Hakon, Wandall, Hans H.

“…Galectins compose a protein family defined by a conserved sequence motif conferring affinity for β-galactose–containing glycans. Moreover, galectins gain…”
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Galectin-8 in IgA Nephritis: Decreased Binding of IgA by Galectin-8 Affinity Chromatography and Associated Increased Binding in Non-IgA Serum Glycoproteins by Carlsson, Michael C., Bakoush, Omran, Tengroth, Lotta, Kilsgård, Ola, Malmström, Johan, Hellmark, Thomas, Segelmark, Mårten, Leffler, Hakon

“…Background Immunoglobulin A nephritis (IgAN) is the most common primary glomerulonephritis worldwide. It is caused by accumulation of IgA1-containing immune…”
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Galectin-3 Guides Intracellular Trafficking of Some Human Serotransferrin Glycoforms by Carlsson, Michael C., Bengtson, Per, Cucak, Helena, Leffler, Hakon

“…Transferrin internalization via clathrin-mediated endocytosis and subsequent recycling after iron delivery has been extensively studied. Here we demonstrate a…”
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Glycosylation of solute carriers: mechanisms and functional consequences by Pedersen, Nis Borbye, Carlsson, Michael C., Pedersen, Stine Falsig

“…Solute carriers (SLCs) are one of the largest groups of multi-spanning membrane proteins in mammals and include ubiquitously expressed proteins as well as…”
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Genetically engineered cell factories produce glycoengineered vaccines that target antigen-presenting cells and reduce antigen-specific T-cell reactivity by Mathiesen, Caroline B.K., Carlsson, Michael C., Brand, Stephanie, Möller, Svenning Rune, Idorn, Manja, thor Straten, Per, Pedersen, Anders E., Dabelsteen, Sally, Halim, Adnan, Würtzen, Peter Adler, Brimnes, Jens, Ipsen, Henrik, Petersen, Bent L., Wandall, Hans H.

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Malignant T Cells Secrete Galectins and Induce Epidermal Hyperproliferation and Disorganized Stratification in a Skin Model of Cutaneous T-Cell Lymphoma by Thode, Christenze, Woetmann, Anders, Wandall, Hans H., Carlsson, Michael C., Qvortrup, Klaus, Kauczok, Claudia S., Wobser, Marion, Printzlau, Andreas, Ødum, Niels, Dabelsteen, Sally

“…Cutaneous T-cell lymphomas (CTCLs) are the most common primary skin lymphomas, which are characterized by an accumulation of malignant T cells in the skin. The…”
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Glycoproteomic Analysis of Seven Major Allergenic Proteins Reveals Novel Post-translational Modifications by Halim, Adnan, Carlsson, Michael C., Madsen, Caroline Benedicte, Brand, Stephanie, Møller, Svenning Rune, Olsen, Carl Erik, Vakhrushev, Sergey Y., Brimnes, Jens, Wurtzen, Peter Adler, Ipsen, Henrik, Petersen, Bent L., Wandall, Hans H.

“…Allergenic proteins such as grass pollen and house dust mite (HDM) proteins are known to trigger hypersensitivity reactions of the immune system, leading to…”
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Different fractions of human serum glycoproteins bind galectin-1 or galectin-8, and their ratio may provide a refined biomarker for pathophysiological conditions in cancer and inflammatory disease by Carlsson, Michael C., Balog, Crina I.A., Kilsgård, Ola, Hellmark, Thomas, Bakoush, Omran, Segelmark, Mårten, Fernö, Mårten, Olsson, Håkan, Malmström, Johan, Wuhrer, Manfred, Leffler, Hakon

“…Changes in glycosylation of serum proteins are common, and various glycoforms are being explored as biomarkers in cancer and inflammation. We recently showed…”
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Intracellular sorting of galectin-8 based on carbohydrate fine specificity by Carlsson, Susanne, Carlsson, Michael C, Leffler, Hakon

“…Galectin-8 has two carbohydrate recognition domains (CRDs), both of which bind β-galactosides, but have different fine specificity for larger saccharides…”
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