Search Results - "Carlson, Timothy J"

Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH) by Min, Xiaoshan, Thibault, Stephen T, Porter, Amy C, Gustin, Darin J, Carlson, Timothy J, Xu, Haoda, Lindstrom, Michelle, Xu, Guifen, Uyeda, Craig, Ma, Zhihua, Li, Yihong, Kayser, Frank, Walker, Nigel P.C, Wang, Zhulun

“…Fatty acid amide hydrolase (FAAH), an amidase-signature family member, is an integral membrane enzyme that degrades lipid amides including the endogenous…”
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In vitro and in vivo pharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin by Grillo, Mark P., Erve, John C. L., Dick, Ryan, Driscoll, James P., Haste, Nicole, Markova, Svetlana, Brun, Priscilla, Carlson, Timothy J., Evanchik, Marc

“…Mavacamten is a small molecule modulator of cardiac myosin designed as an orally administered drug for the treatment of patients with hypertrophic…”
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Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations by Matthew Hutzler, J, Wienkers, Larry C, Wahlstrom, Jan L, Carlson, Timothy J, Tracy, Timothy S

“…Studies were designed to investigate the possible mechanisms associated with the kinetic observation of CYP2C9 activation by dapsone and its phase I…”
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Metabolite Profiling and Reaction Phenotyping for the in Vitro Assessment of the Bioactivation of Bromfenac by Yadav, Aprajita S, Shah, Nina R, Carlson, Timothy J, Driscoll, James P

“…Bromfenac is a nonsteroidal anti-inflammatory drug that was approved and subsequently withdrawn from the market because of reported cases of acute…”
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A three-year clinical evaluation of two dentin bonding agents by Matis, Bruce A, Cochran, Michael J, Carlson, Timothy J, Guba, Christanne, Eckert, George J

“…A new restorative called a "giomer composite" has been introduced. The authors conducted a study to determine retention, anatomical form, caries, staining,…”
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Structure guided design of a series of sphingosine kinase (SphK) inhibitors by Gustin, Darin J., Li, Yihong, Brown, Matthew L., Min, Xiaoshan, Schmitt, Mike J., Wanska, Malgorzata, Wang, Xiaodong, Connors, Richard, Johnstone, Sheere, Cardozo, Mario, Cheng, Alan C., Jeffries, Shawn, Franks, Brendon, Li, Shyun, Shen, Shanling, Wong, Mariwil, Wesche, Holger, Xu, Guifen, Carlson, Timothy J., Plant, Matthew, Morgenstern, Kurt, Rex, Karen, Schmitt, Joanna, Coxon, Angela, Walker, Nigel, Kayser, Frank, Wang, Zhulun

“…Sphingosine-1-phosphate (S1P) signaling plays a vital role in mitogenesis, cell migration and angiogenesis. Sphingosine kinases (SphKs) catalyze a key step in…”
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Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3 by Li, Zhihong, Wang, Xianghong, Eksterowicz, John, Gribble, Michael W, Alba, Grace Q, Ayres, Merrill, Carlson, Timothy J, Chen, Ada, Chen, Xiaoqi, Cho, Robert, Connors, Richard V, DeGraffenreid, Michael, Deignan, Jeffrey T, Duquette, Jason, Fan, Pingchen, Fisher, Benjamin, Fu, Jiasheng, Huard, Justin N, Kaizerman, Jacob, Keegan, Kathleen S, Li, Cong, Li, Kexue, Li, Yunxiao, Liang, Lingming, Liu, Wen, Lively, Sarah E, Lo, Mei-Chu, Ma, Ji, McMinn, Dustin L, Mihalic, Jeffrey T, Modi, Kriti, Ngo, Rachel, Pattabiraman, Kanaka, Piper, Derek E, Queva, Christophe, Ragains, Mark L, Suchomel, Julia, Thibault, Steve, Walker, Nigel, Wang, Xiaodong, Wang, Zhulun, Wanska, Malgorzata, Wehn, Paul M, Weidner, Margaret F, Zhang, Alex J, Zhao, Xiaoning, Kamb, Alexander, Wickramasinghe, Dineli, Dai, Kang, McGee, Lawrence R, Medina, Julio C

“…We describe the structural optimization of a lead compound 1 that exhibits dual inhibitory activities against FLT3 and CDK4. A series of…”
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An infinitary extension of the Graham--Rothschild Parameter Sets Theorem by Carlson, Timothy J., Hindman, Neil, Strauss, Dona

“…The {\it Graham-Rothschild Parameter Sets Theorem} is one of the most powerful results of Ramsey Theory. (The Hales-Jewett Theorem is its most trivial…”
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MS(M), an efficient workflow for metabolite identification using hybrid linear ion trap Orbitrap mass spectrometer by Cho, Robert, Huang, Yingying, Schwartz, Jae C, Chen, Yan, Carlson, Timothy J, Ma, Ji

“…Identification of drug metabolites can often yield important information regarding clearance mechanism, pharmacologic activity, or toxicity for drug candidate…”
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Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors by Gustin, Darin J., Ma, Zhihua, Min, Xiaoshan, Li, Yihong, Hedberg, Christine, Guimaraes, Cris, Porter, Amy C., Lindstrom, Michelle, Lester-Zeiner, Dianna, Xu, Guifen, Carlson, Timothy J., Xiao, Shouhua, Meleza, Cesar, Connors, Richard, Wang, Zhulun, Kayser, Frank

“…Starting from a series of ureas that were determined to be mechanism-based inhibitors of FAAH, several spirocyclic ureas and lactams were designed and…”
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Reagent-free LC-MS/MS-based pharmacokinetic quantification of polyhistidine-tagged therapeutic proteins by Shi, Jianxia, Wong, Jing Man, Ma, Ji, Dickerson, Tiffany, Hall, Colin, Rock, Dan A, Carlson, Timothy J

“…Immobilized metal ion affinity chromatography is widely employed for purifying polyhistidine-tagged recombinant proteins from cell lysates. The technique can…”
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MSM, an Efficient Workflow for Metabolite Identification Using Hybrid Linear Ion Trap Orbitrap Mass Spectrometer by Cho, Robert, Huang, Yingying, Schwartz, Jae C., Chen, Yan, Carlson, Timothy J., Ma, Ji

“…Identification of drug metabolites can often yield important information regarding clearance mechanism, pharmacologic activity, or toxicity for drug candidate…”
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On the conservativity of the axiom of choice over set theory by Carlson, Timothy J.

“…We show that for various set theories T including ZF, T + AC is conservative over T for sentences of the form A(x, y) where A(x, y) is a Δ 0 formula…”
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Normal forms for elementary patterns by Carlson, Timothy J., Wilken, Gunnar

“…A notation for an ordinal using patterns of resemblance is based on choosing an isominimal set of ordinals containing the given ordinal. There are many choices…”
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Development of a robust and sensitive LC–MS/MS method for the determination of adenine in plasma of different species and its application to in vivo studies by Shi, Jianxia, Liu, Hua-Fen, Wong, Jing Man, Huang, Renee N., Jones, Elliott, Carlson, Timothy J.

“…A simple, robust, and sensitive liquid chromatography–tandem mass spectrometric (LC–MS/MS) method was developed for the measurement of endogenous adenine in…”
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Recent advances in high throughput screening for ADME properties by Carlson, Timothy J, Fisher, Michael B

“…With the increase in the numbers of molecules synthesized in a typical drug discovery program, as well as the large amount of information utilized in the…”
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Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism by Wehn, Paul M., Harrington, Paul E., Carlson, Timothy J., Davis, James, Deprez, Pierre, Fotsch, Christopher H., Grillo, Mark P., Lu, Jenny Ying-Lin, Morony, Sean, Pattabiraman, Kanaka, Poon, Steve F., Reagan, Jeff D., St. Jean, David J., Temal, Taoues, Wang, Minghan, Yang, Yuhua, Henley, Charles, Lively, Sarah E.

“…A series of urea based calcimimetics was optimized for potency and oral bioavailability. Crucial to this process was overcoming the poor pharmacokinetic…”
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High Confidence Predictions of Drug−Drug Interactions: Predicting Affinities for Cytochrome P450 2C9 with Multiple Computational Methods by Hudelson, Matthew G, Ketkar, Nikhil S, Holder, Lawrence B, Carlson, Timothy J, Peng, Chi-Chi, Waldher, Benjamin J, Jones, Jeffrey P

“…Four different models are used to predict whether a compound will bind to 2C9 with a Ki value of less than 10 µM. A training set of 276 compounds and a diverse…”
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Clinical evaluation of in-office and at-home bleaching treatments by Zekonis, Ruta, Matis, Bruce A, Cochran, Michael A, Al Shetri, Sala E, Eckert, George J, Carlson, Timothy J

“…This three-month, single-blind clinical study compared two whitening treatments, at-home with 10% carbamide peroxide and in-office with 35% hydrogen peroxide,…”
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Application of DBS sampling in combination with LC-MS/MS for pharmacokinetic evaluation of a compound with species-specific blood-to-plasma partitioning by Xu, Guifen, Chen, Jiyun S, Phadnis, Ruta, Huang, Tom, Uyeda, Craig, Soto, Marcus, Stouch, Brian, Wells, Mary C, James, Christopher A, Carlson, Timothy J

“…Dried blood spot (DBS) sampling in combination with LC-MS/MS has been used increasingly in drug discovery for quantitative analysis to support pharmacokinetic…”
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